Nervous system 3 & 4

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1
Cell body
Main part of the cell where the neucleous is
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Dendrites
Recieving end of the neuron
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Axon
Extention of thew cell body where electrical signals pass through
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Myelin Sheath
fatty insulation of axons that speeds up the speed of electrical signals
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Axon Terminal
Contains vesicles filled with neurotransmitters
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Agonists
Drugs that strengthen the effect of a neurotransmitter
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Sympathomimetic
Drug that mimics the effect of the sympathetic nervous system
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Antagonists
Drugs that disrupt signaling between two neurons (e.g., block receptors)
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Sodium potassium pumps
Pumps 2 potassium in for every 3 sodium out
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Three proteins for cells
Na K pumps, K leak channel, Na leak channel
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Threshold for action potential
-55mV; if reached, the neuron fires an action potential
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Graded potentials
Local changes in membrane potential that make a cell more or less likely to fire
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Chemically gated potassium (K) channel
Activated by neurotransmitter, allows more K to leave the cell making it more negative (hyperpolarized
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Chemically gated Sodium (Na) channel
Allows sodium to enter the cell making it more positive and more likely to fire (excitatory)
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Action potential
Voltage gated sodium channels open at -55mV letting in more sodium causing a chain reaction that travels down the axon
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All or none principle
A neuron either sends an action potential or it doesn't; signal strength is the same every time
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Increasing signal urgency
If an urgent signal needs to be sent, the frequency of action potentials goes up (e.g., 1
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Sodium potassium pumps during action potential
Go into overdrive to bring the neuron back to rest
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Spinal cord outer layer
White because of myelin around axons
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Spinal cord inner layer
Grey because it is where all the cell bodies are
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Ventral horn
On the anterior; contains cell bodies of somatic motor neurons
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Dorsal horn
On the posterior; where all sensory information enters the spinal cord
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Ventral rootlets
Somatic neuron axons that merge to form a ventral root sending motor information to the body
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Dorsal rootlets
Combine to form a dorsal root which sends sensory information to the brain
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Spinal nerve
Formed when the ventral and dorsal roots combine
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Ganglion
Cluster of cell bodies in the Peripheral Nervous System (bump where dorsal rootlets meet the root)
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Nucleus (spinal cord context)
Cluster of neuron cell bodies in the Central Nervous System
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Anterior spinal artery
Supplies a large part of the spinal cord with blood (roughly 80%)
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Posterior spinal arteries
Supply the back part of the spinal cord with blood (about 10% per artery)
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Reflex
Fast, involuntary, stereotyped motor response to a specific sensory stimulus
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Neuroglia
Support cells that enhance neurons so they can do their job
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Astrocytes
Maintain the blood brain barrier
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Schwann cells
Myelinate peripheral neurons
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Oligodendrocytes
Myelinate central nervous system
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Ependymal cells
Make cerebrospinal fluid (distributes nutrition and prevents brain trauma)
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Microglia
Immune cells in the central nervous system
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Membrane potential
Electrical charge along the membrane
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Resting membrane potential
Electrical charge at rest
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Most important ions for charge
Sodium and potassium
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Ion distribution
Potassium is mostly inside the cell, sodium is mostly outside the cell
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Sodium potassium pump ATP cost
Takes a lot of ATP (up to 70% of all ATP a cell makes)
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Leak channels
Allow potassium to leave the cell or sodium to enter
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Potassium leaking effect
Potassium is positively charged, so as it leaks out the cell becomes negative
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Potassium equilibrium
Once the cell becomes negative, potassium slows down and reaches balance with the outside
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Sodium permeability effect
If the cell were permeable to sodium, sodium would enter making the cell positive until repelled and balanced
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Sodium equilibrium potential
+60mV
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Potassium equilibrium potential
-90mV
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Resting membrane potential (actual value)
-70mV because potassium has more channels so it tends toward potassium's resting number
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Myelination and speed
The more myelinated a neuron is, the faster a signal is sent
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Neuron regrowth
Neuron can regrow if endoneurium scaffolding and myelin remain; grows about 1 millimeter per day
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Multipolar neuron
Many dendrites and one axon (most common)
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Bipolar neuron
One dendrite and one axon (rarest)
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Pseudounipolar neuron
Cell body off to the side; single dendrite and axon look like a single line (all somatosensory neurons)
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