1What are the two major divisions of the cardiovascular system?
The pulmonary circuit and the systemic circuit.
2What does the pulmonary circuit do?
Carries blood between the heart and lungs for gas exchange.
3What does the systemic circuit do?
Carries blood between the heart and the rest of the body.
4What does the right side of the heart pump?
Deoxygenated blood to the lungs.
5What does the left side of the heart pump?
Oxygenated blood to the body.
6Which arteries carry deoxygenated blood?
Pulmonary arteries.
7Which veins carry oxygenated blood?
Pulmonary veins.
8What is the pathway of blood through the heart?
Vena cava, right atrium, tricuspid valve, right ventricle, pulmonary valve, pulmonary arteries, lungs, pulmonary veins, left atrium, mitral valve, left ventricle, aortic valve, aorta.
9What is the function of the atria?
Receive blood returning to the heart.
10What is the function of the ventricles?
Pump blood out of the heart.
11What is the function of the tricuspid valve?
Prevents backflow from the right ventricle into the right atrium.
12What is the function of the bicuspid or mitral valve?
Prevents backflow from the left ventricle into the left atrium.
13What do the pulmonary and aortic valves prevent?
Backflow from the arteries into the ventricles.
14What do the chordae tendineae do?
Anchor the AV valves and prevent them from prolapsing.
15What do the papillary muscles do?
Tighten the chordae tendineae during ventricular contraction.
16What is the pericardium?
The protective sac surrounding the heart.
17What are intercalated disks?
Connections between cardiac muscle cells that help them contract together.
18What do gap junctions in intercalated disks allow?
Electrical signals to pass between cardiac muscle cells.
19What are the two major types of cardiac muscle cells?
Autorhythmic cells and contractile cells.
20What is the function of autorhythmic cells?
Generate action potentials that initiate the heartbeat.
21What is the function of contractile cardiac cells?
Generate force to pump blood.
22How are cardiac contractile cells different from pacemaker cells?
Contractile cells have organized sarcomeres and generate force; pacemaker cells generate electrical signals.
23What are the characteristics of cardiac muscle cells?
They are striated, branched, usually have one nucleus, connect through intercalated disks, and contain many mitochondria.
24What is the sinoatrial (SA) node?
The heart's primary pacemaker.
25What is the atrioventricular (AV) node?
The structure that delays and relays electrical signals to the ventricles.
26What is the purpose of AV node delay?
Allows the atria to finish contracting before the ventricles contract.
27What is the pathway of electrical conduction through the heart?
SA node, atria, AV node, bundle of His, bundle branches, Purkinje fibers, ventricles.
28What is the normal pacemaker rate of the SA node?
About 60–100 beats per minute.
29What is the intrinsic pacemaker rate of the AV node?
About 40–60 beats per minute.
30What is the intrinsic pacemaker rate of Purkinje fibers?
About 20–40 beats per minute.
31What happens when the SA node fires?
The electrical signal spreads through the atria and reaches the AV node.
32What is an electrocardiogram (ECG or EKG)?
A recording of the heart's electrical activity.
33What does the P wave represent?
Atrial depolarization.
34What happens mechanically after the P wave?
The atria contract.
35What does the QRS complex represent?
Ventricular depolarization.
36What happens mechanically after the QRS complex?
The ventricles contract.
37What does the T wave represent?
Ventricular repolarization.
38What happens mechanically after the T wave?
The ventricles relax.
39What does the PR interval represent?
The time for electrical activity to travel from the atria through the AV node toward the ventricles.
40What does the ST segment represent?
The period when the ventricles are depolarized.
41How can heart rate be estimated from an ECG?
Count the number of QRS complexes per minute or use the time between successive R waves.
42What is systole?
The contraction phase of the heart.
43What is diastole?
The relaxation and filling phase of the heart.
44What is the cardiac cycle?
The sequence of contraction and relaxation during one heartbeat.
45What are the five phases of the cardiac cycle?
Late diastole, atrial systole, isovolumetric ventricular contraction, ventricular ejection, and isovolumetric ventricular relaxation.
46What happens during late diastole?
The atria and ventricles are relaxed and the ventricles passively fill with blood.
47What happens during atrial systole?
The atria contract and push remaining blood into the ventricles.
48What happens during isovolumetric ventricular contraction?
The ventricles contract while all valves are closed, increasing pressure without changing volume.
49What happens during ventricular ejection?
The semilunar valves open and blood leaves the ventricles.
50What happens during isovolumetric ventricular relaxation?
The ventricles relax while all valves are closed, decreasing pressure without changing volume.
51What causes the first heart sound, S1 or "lub"?
Closure of the AV valves.
52What causes the second heart sound, S2 or "dub"?
Closure of the semilunar valves.
53What is end-diastolic volume (EDV)?
The amount of blood in a ventricle at the end of filling.
54What is end-systolic volume (ESV)?
The amount of blood remaining in a ventricle after contraction.
55What is stroke volume?
The amount of blood pumped out by one ventricle per beat.
56What is the formula for stroke volume?
SV = EDV - ESV
57What is cardiac output?
The volume of blood pumped by one ventricle per minute.
58What is the formula for cardiac output?
CO = HR * SV
59What happens to cardiac output when heart rate increases and stroke volume stays constant?
Cardiac output increases.
60What happens to cardiac output when stroke volume increases and heart rate stays constant?
Cardiac output increases.
61What is ejection fraction?
The percentage of end-diastolic volume ejected during contraction.
62What is the formula for ejection fraction?
EF = (SV / EDV) *100
63What is preload?
The stretch of ventricular muscle before contraction, related to end-diastolic filling.
64What is afterload?
The pressure or resistance the ventricles must overcome to eject blood.
65What is contractility or inotropy?
The ability of cardiac muscle to generate force at a given muscle length.
66What is a positive inotrope?
A substance that increases cardiac contractility.
67What is a negative inotrope?
A substance that decreases cardiac contractility.
68What are examples of positive inotropes?
Epinephrine, norepinephrine, and digitalis.
69What determines the strength of cardiac muscle contraction?
The amount of calcium bound to troponin and the number of active cross-bridges.
70How does increased calcium availability affect cardiac contraction?
It increases the force of contraction.
71What is the Frank-Starling law?
Increased ventricular filling stretches cardiac muscle and produces a stronger contraction.
72How is stroke volume related to EDV?
Stroke volume generally increases as EDV increases.
73How does increased venous return affect stroke volume?
It increases EDV and usually increases stroke volume.
74What are three mechanisms that increase venous return?
Venoconstriction, the skeletal muscle pump, and the respiratory pump.
75What does the skeletal muscle pump do?
Contracting skeletal muscles squeeze veins and help return blood to the heart.
76What does the respiratory pump do?
Pressure changes during breathing help move venous blood toward the heart.
77How does sympathetic stimulation affect heart rate?
Increases heart rate.
78How does parasympathetic stimulation affect heart rate?
Decreases heart rate.
79Which autonomic division normally dominates resting heart rate?
Parasympathetic activity.
80How does sympathetic stimulation affect contractility?
Increases ventricular contractility.
81How does parasympathetic stimulation affect cardiac contractility?
It has its strongest effect on heart rate and has little direct effect on ventricular contractility.
82How does sympathetic stimulation affect pacemaker cells?
Increases sodium and calcium permeability, speeding pacemaker depolarization.
83How does parasympathetic stimulation affect pacemaker cells?
Increases potassium permeability and decreases calcium permeability, slowing pacemaker depolarization.
84What receptor does sympathetic stimulation use on cardiac pacemaker cells?
Beta-1 adrenergic receptors.
85What is tonic control of heart rate?
The ongoing autonomic influence that adjusts heart rate; resting heart rate is normally dominated by parasympathetic activity.
86What are the four phases of the cardiac contractile-cell action potential?
Rapid depolarization, initial repolarization, plateau, and repolarization.
87What causes rapid depolarization in a cardiac contractile cell?
Rapid sodium influx.
88What causes initial repolarization in a cardiac contractile cell?
Sodium channels close and potassium begins leaving the cell.
89What causes the plateau phase of the cardiac contractile action potential?
Calcium influx balanced by potassium leaving the cell.
90Why is the cardiac action potential plateau important?
It creates a long refractory period and prevents sustained tetanic contraction.
91What causes repolarization in a cardiac contractile cell?
Calcium channels close and potassium leaves the cell.
92How does a pacemaker action potential differ from a contractile-cell action potential?
Pacemaker cells spontaneously depolarize and do not have the same stable resting potential or plateau.
93What causes spontaneous depolarization in pacemaker cells?
Slow inward positive current, including funny sodium current and calcium entry.
94What causes depolarization in pacemaker cells?
Calcium influx.
95What causes repolarization in pacemaker cells?
Potassium efflux.
96What does the NCX antiporter do?
Exchanges sodium and calcium across the cell membrane.
97Does the NCX antiporter directly use ATP?
No, it uses the sodium gradient maintained by the sodium-potassium pump.
98What is the function of phospholamban in cardiac muscle?
It regulates calcium storage in the sarcoplasmic reticulum.
99How do catecholamines increase cardiac contractility?
They increase calcium availability and calcium storage in cardiac muscle.
100What is the cardiovascular system's pressure reservoir?
The arterial system.
101What is the cardiovascular system's volume reservoir?
The venous system.
102What is the main function of arteries?
Carry blood away from the heart and maintain pressure.
103What is the main function of arterioles?
Regulate resistance and distribute blood to tissues.
104What is the main function of capillaries?
Allow exchange of gases, nutrients, and wastes.
105What is the main function of venules?
Collect blood from capillaries.
106What is the main function of veins?
Return blood to the heart and act as a blood-volume reservoir.
107What is the aorta?
The large artery carrying blood from the left ventricle to the systemic circulation.
108What is the vena cava?
The large veins that return systemic blood to the right atrium.
109Which blood vessels have the greatest smooth muscle control over diameter?
Arterioles.
110Which blood vessels contain abundant elastic tissue?
Large arteries.
111Which blood vessels have very thin walls for exchange?
Capillaries.
112What is endothelium?
The thin layer of cells lining blood vessels.
113What is angiogenesis?
The formation of new blood vessels.
114What is blood flow?
The volume of blood moving through a vessel or circulation per unit time.
115What causes blood to flow?
A pressure gradient.
116What happens when there is no pressure gradient?
There is no net blood flow.
117Does blood flow depend on absolute pressure or pressure difference?
Pressure difference.
118What is the relationship between pressure gradient and flow?
Greater pressure difference produces greater flow if resistance stays constant.
119What is the relationship between resistance and flow?
Greater resistance decreases flow if the pressure gradient stays constant.