Chapter 3: Lyme Disease
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1
Disease classification of Lime disease?
*Spirochetal infection
2
Causative organism of lyme disease?
*Borellia burgdorferi
3
Information about Borellia burgdorfer classificationi:
*spirochete
*weak gram negative bacteria
*weak gram negative bacteria
4
Physical characteristics of Borellia burgdorferi
*microaerobic (doesn't need a lot of oxygen)
*motile because of bundled perisplasmic flagella
*slow growing 24-48 hr doubling time
*motile because of bundled perisplasmic flagella
*slow growing 24-48 hr doubling time
5
What is epidemiology of Borellia burgdorfer?
*reservoir: ticks and other animals (deer)
*portal of entry: epidermic
*mode of transmission: arthropod vector (black legged deer) tick bite (ussually 36-48 hr duration)
*portal of entry: epidermic
*mode of transmission: arthropod vector (black legged deer) tick bite (ussually 36-48 hr duration)
6
How much time is ussually needed for transission of Borelia burgdorfer?
*36-48 hrs of being on body
7
Incubation period of lyme disease?
*3-30 dys
8
Pathogenesis of Lyme disease?
*spirochete injeted into skin (multiplies and spreads radially)
*spirochetes enters lymphatic and circulatory system (spread throughout body)
*leads to chronic spirochete infection and immune response to damaged tissues
*spirochetes enters lymphatic and circulatory system (spread throughout body)
*leads to chronic spirochete infection and immune response to damaged tissues
9
Signs and symptoms of Lyme Disease (Borellia burgorferi)
*erythema migrans (bull's eye rash)
*flu like symptoms (fever, chills, headache, faigue, muscle and joint aches, swollen lymph nodes)
*flu like symptoms (fever, chills, headache, faigue, muscle and joint aches, swollen lymph nodes)
10
When do signs and symptoms typically appear?
3-30 dys after bite
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