Chapter 53 Pharm

contain many triglycerides

cholesterol primary core lipid
greatest contributor to coronary heart disease (CHD)

20-30% of cholesterol in blood and taken back to the liver
pick up cholesterol and take back to the liver = good

increased high blood glucose - hyperglycemia
increased high triglycerides
increased high apolipoprotein B
decreased low high-density lipoprotein (HDL)
increased levels above 150 mg/dL

most effectvie drugs for lowering LDL
decrease of LDL cholesterol
increase of HDL cholesterol
decrease of triglyceride levels

class: Statins
use: hypercholesterolemia
adverse: headache, rash, GI disturbances
rare adverse: myopathy/ rhabdomyolysis and hepatotoxicity
use in pregnancy = FDA Category X, contraindicated
dosing should be once daily in the evening

class: bile-acid sequestrants
decrease in LDL cholesterol
use: reduces LDL cholesterol
adverse: constipation

most effective drugs available for lowering TG levels
can raise HDL cholesterol
little or no effect on LDL cholesterol
use: reduces high levels of plasma triglycerides for pt who do not respond to diet modifications
adverse: rashes, gallstones, liver injury