Leprosy (Hansen's Disease
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1
What is leprosy also known as?
Hansen's Disease
2
CO:
Mycobacterium leprae
3
Classification of Mycobacterium leprae?
*gram positive rod (GPR)
*acid fast
*aerobic (needs O2)
*obligate intracellular parasite
*acid fast
*aerobic (needs O2)
*obligate intracellular parasite
4
What type of cells do Mycobacterium leprae invade?
Schwann cells (associated with peripheral neurons)
macrophages of skin cells
macrophages of skin cells
5
What is doubling time of Mycobacterium leprae?
11-13 days
6
R:
Armadillos, Humans
7
POI:
Skin, Mucosa, upper respiratory tract
8
MOT:
all likely
-respiratory droplets
-direct skin contact
-zoonotic
-respiratory droplets
-direct skin contact
-zoonotic
9
Pathogenesis:
*bacteria invents skin cells macrophages and periphernal nerves (colder extremities)
*immune response leads to development of tubercles and/or tissue/nerve damage/loss
*immune response leads to development of tubercles and/or tissue/nerve damage/loss
10
What does tissue damage from bacteria lead to? (pathogenesis)
*nerve damage (loss of sensory perception)
*non-inflammatory cell death
*non-inflammatory cell death
11
incubation period?
3 months-20 yrs
12
What types of skin lesions associated?
*hypopigmented
*raised flat, dry and scaly, red patches
*reversal rx also possible (plaques with red border)
*numbness
*painless ulcers
*raised flat, dry and scaly, red patches
*reversal rx also possible (plaques with red border)
*numbness
*painless ulcers
13
Complications?
*nerve damage
*paralysis
*deformaties (clawed hand)
*tissue necrosis
*corneal ulcers
*bone loss (digit resorption)
*infertility
*paralysis
*deformaties (clawed hand)
*tissue necrosis
*corneal ulcers
*bone loss (digit resorption)
*infertility
14
Average incubation period?
*5 years, asymptomatic
15
Prevention for leprosy? Efficacy?
*avoid contact with infected individuals/animals
*Tuberculosis (BCG) vaccine (32-86% effective)
*Tuberculosis (BCG) vaccine (32-86% effective)
16
Treatment for Leprosy? Be specific with mechanism of action and duration:
*multiple antibiotic therapy (6-12 months)
-rifampin (rna polymerase inhibitor)
-dapsone (sulfanamide/metabolism inhibitor)
-clofazimine
-rifampin (rna polymerase inhibitor)
-dapsone (sulfanamide/metabolism inhibitor)
-clofazimine
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