COVID 19

Viral Respiratory tract infection, pneumonia

Coronaviridae Beta-coronavirus SARS- Cov 2

enveloped virus, spike protien binds ACE II on cells for entry, +SS RNA genome (29KB), 50-200nm in diameter, genome codes for 27 different protiens

Infected humans and some other animals (bats)

Respiratory tract; conjunctiva of the eyes passing through nasolacrimal duct; oral cavity and esophagus

Direct contact, droplet, aerosolized (3hrs), Indirect (viable on surfaces up to 3 days)

2-14 days- now more like 5-10

Within the host cell the virus takes over and multiples within cell (stage 1), viral replication causes cell damage and virus spreads to nearby cells, immune system is triggered (stage 2), infection spreads to lower respiratory tract (alveolar cells or other organs with ACE2 receptors) whichs results in pneumonia (stage 3)

drmatic drop in blood pressure, leaky blood vessels, formation of blood clots, or organ failure

Virus is detected via nasal swab and spread via droplets, virus propagates, mild innate immune response initiated

cough, fever, shortness of breath, chills, muscle pain, fatigue, headache, loss of taste and /or smell, sore throat, nausea, diarrhea.

Pneumonia, difficulty breathing, persitant chest pain/pressure, confusion, inability to stay awake, bluish lips or skin

Leaky blood vessels, LBP, formation of blood clots, organ failure, seizes, strokes, heart attacks, Pediatric multisystem inflammatory syndrome, chronic fatigue, mortality (death), and post covid conditions ‘long covid’

Vaccines- Pfizer-BioNTech, Moderna, JnJ, avoid exposure, social distancing, wear masks, handwashing