Hormones and Sexual Dimorphism

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1
androgens
class of hormones that activates androgen receptors
2
testosterone
can affect body by binding to androgen receptors or being converted to DHT or estradiol (estrogen)
3
dihydrotestosterone (DHT)
can affect the body by binding to receptors, is a stronger version of testosterone (less needed)
4
estrogen
class of hormones that activates estrogen receptors
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estradiol
can be produced in ovaries or in the brain (in males), can affect the body by binding to estrogen receptors
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cholesterol
starting material for hormones like testosterone, DHT, and estradiol
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aromatase
converts testosterone into estradiol
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5𝛼-reductase
turns testosterone into DHT
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5𝛼-reductase deficiency
body can't make DHT, high testosterone levels in puberty to make up for loss of DHT (female appearance at birth, induces male typical appearance)
10
androgen insensitivity syndrome
normal testes and testosterone levels, mutation in androgen receptor gene prevents body from responding to T or DHT (female appearance for life)
11
what brain regions are bigger in males?
sexually dimorphic nucleus (SDN) of preoptic area, medial amygdala
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what brain region is bigger in women?
anterior ventral periventricular region
13
how do hormone mutations cause sex differences in the brain?
testosterone acts (conversion to estradiol by aromatase) near time of birth to increase the size of the SDN
14
CUT & RUN
a method in which an antibody is used to determine which DNA sequences are targeted by transcription factors like estrogen receptors
15
what were the sex differences found in the vervet monkey study?
when given the choice between toys with wheels and dolls, males preferred wheeled toys, but females played with both
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what were the results of the rough and tumble study?
testosterone increased rough and tumble play in females
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congenital adrenal hyperplasia (CAH)
a disorder where the adrenal gland produces androgens instead of cortisol, resulting in ambiguous genitals in girls
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how is CAH treated?
can be treated with a form of cortisol (dexamethasone) and reconstructive surgery, results in normal life most of the time
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dexamethasone
artificial cortisol that tricks brain into thinking cortisol is present, reduces androgen production by adrenal glands
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what was found about many of the girls who were treated for CAH?
preferred male playmates and often characterized as "tomboys", displayed reduced interest in infant care
21
gynandromorph
literally half male and half female
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