Ide-cel - PBMC Thaw & Culture Initiation
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1
What is Plasmatherm used for
thawing frozen PBMC
2
How is cell culture created
When PBMCs are mixed with TCGMs
3
How is the culture initiated
when antibodies are added to the culture
4
What are the antibodies added to the culture
CD3 and CD28
5
APC stands for
antigen presenting cells
6
what happens to T cells after they become active
They produced their own IL2
7
What is IL2
It is a cytokine produced by activated T cells
8
What does IL2 stand for
Interleukin-2
9
Why is IL2 significant
It promotes the expansion, differentiation, and activation of T cells in response to antigens
10
What are antibodies
proteins produced by B cells in response to presence of antigens
11
what are antigen presenting cells
category of cells that wear the antigen on their surface for T cells to recognize
12
What happens when T cell comes across an antigen
The T cell activates
13
What happens when a T cell activates?
it begins expansion
14
What is an antigen
a substance/molecule that triggers an immune response
15
What does an antibody do?
Binds to specific antigens and marks them for destruction by the immune system
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