MCB Lec 11

product of one enzyme is often the substrate of the next enzyme, helps channel substrates into the enzymes , rate of cell metabolism increases

allows intermedietes to move efficently through active sites, some enzymes have multiple active sites and either lose or gain NH3

Tightly wound covalent or noncovalent dissasociates slowly from target enzyme

enzyme-inhibitor rapidly dessasociates and thie is compettive, noncompetitve, and uncompetitive

Competitive inhibitor mimics the structure of substrate and competes w substrate for the same binding cite, only binds to free enzyme

Non-competitive inhibitor binds to a side distinct from the active site does not substrate binding binds free enzyme or ES

uncompetitve only binds to ES complex

protiens that can adopt two or more structures when a ligand binds

displays sigmoidal kinetcs

in some multi subunit enzymes, ligand binding to to one unit chaning the effects

most cells Low Km

liver high Km

effects of substrate on allosteric protiens

effects of non substrate molecules on the protiens

Serine. cystine. aspartl process, and metalprotiease

long polar side chains