Oncology Comp exam

Acute Graft v. Host Disease (AGVHD) is a serious complication of _________ which typically occurs _______ after transplant and is characterized by ________. it is primarily _______ mediated

Chronic GVHD presents after ___ days and is accompanied by ________. Usually involves the ______, _____, ____, and _____

Clinical manifestations of AGVHD include

Graft v. Host Disease cutaneous initially presents as erythematous __________ on the _____, _____, or ________; and then generalizes into a morbilliform or ________ type rash, _____, _____, ______

Graft v. Host Disease Cutaneous treatment includes _______, _______, ________ for chronic, ________, and oral care

Graft v. Host Disease GI presentation includes _______, _______, _______, & increased _______

Graft v. Host Disease GI treatment includes _____, _______, & _______

Typhlitis aka _________ triad symptoms....

Typhlitis aka Neutropenic Enterocolitis is a potentially life-threatening infection d/t ________ damage from ______

Oral open lesions can be associated with ______ and can also be a port for systemic infection

What medications should you avoid in patients with Typhitis?

Veno-Occlusive Disease (VOD) is blockage of the venous system of the _____ leading to _____

Risk Factors of Veno-Occlusive Disease (VOD) include ______ & ______

Superior Vena Cava Syndrome is _____ of the SVC by _____, _____, or _____ leading to _______ --> ______

Hyperleukocytosis is a dangerously high WBC count > _____; risk for ____

Hyperleukocytosis is most commonly seen in ____

Most common complication of Hyperleukocytosis is _______

In a pt with Hyperleukocytosis you should avoid _____ & _____ to prevent further_______; Goal Hgb is _____

Elevated ______, _______, & ______ levels are indicative of tumor lysis syndrome, a side effect of chemotherapy when tumor cells are broken down. Elevated ______ with low _____ can indicate renal failure which occurs as a result of tumor lysis syndrome.

Tumor Lysis Syndrome (TLS) is associated with _______; especially with ____, ____, or _____

Tumor Lysis Syndrome (TLS) impacts the _____, ____, _____, & _____ function

Risk Factors for Tumor Lysis Syndrome (TLS) include ______, ______, _____, _____, & ______

Bone Marrow Aspirate (BMA) w/ _____% blasts = leukemia

Leukemia is the abnormal _______ & ______ of immature _________ in blood/ bone marrow causing _________; & in other organs including ______, ____, _____, _____, _____, & _______

Most common childhood cancer is ________

CAR-T Cell therapy Modifies autologous T cells to express a receptor which targets _____ on the surface of ____

CAR-T cell therapy has risks for serious and potentially fatal complications, including ______, _______, & _______

Prophylaxis for every leukemia patient is _______

CNS treatment for high risk leukemia patients include ______, _____, _____, _____, _____ & _______

Lymphoma is malignancy of the _____ arising in the ______; It is the _____ most common pediatric cancer

Hodgkins lymphoma is more common in ______ & ________; Ages _____ to _____ y.o

Hodgkins lymphoma spreads in a contiguous (contact) manner to _______ but rarely involves ____ sites; Spreads ____ than NHL

Children with _________ are at greater risk for Hodgkins lymphoma; also associated w/ _____

Non-Hodgkins Lymphoma is more common in ______ children, ages ___ to ___

Non-Hodgkins Lymphoma can spread _______ & involve extranoday sites including the ____, _____, & _____; Spreads more ______ & ____ than HL

Osteosarcoma & Ewing’s Sarcoma is proliferation of the ______ or _______ cell with peak incidence during ______

Osteosarcoma effects the _______ region; Up to 20% metastasize at dx to the ____ and _____

Ewing Sarcoma effects the _____ regions or ______; 25% metastisize to _____, _____, or _____

Codman triangle seen on xray in _____ or ______ is a _____ reaction seen when an aggressive bone lesion...... Only the periosteum at the very margin of the lesion has time to ossify creating a triangular lip of _______

Rhabdomyosarcoma is a _______ tumor from _______ cells; 50% originate from ________ cells & has 3 main variants including ______, _____, & _______

Embryonal Form of Rhabdomyosarcoma occurs _________ but most often in the ______, _____, ______, and ______ and is more common in ___ to ___ y.o

Botryoid Rhabdomyosarcoma is seen in the _____ or ______ and is more common in ______

Alveolar Rhabdomyosarcoma occurs in the _____ or ______ and is more common in ____ & _____

2/3rds of Rhabdomyosarcoma cases occur in pts <_____ y.o. It is slightly more common in _____ and ______; Associated with _____

Wilms Tumor or Nephroblastoma is a tumor from _______ precursor cells; Most common in kids b/t ___ to ___ y.o; 90% dx before _____

Wilms Tumor or Nephroblastoma is associated with ____ syndromes, including _____ & ______

Wilms Tumor or Nephroblastoma is usually found by ____ during _____ or during ________

Neuroblastoma is a neoplasm of the ________; It's the most common ______ solid tumor

Neuroblastoma is the most frequently diagnosed malignancy during _____ & is slightly more common in ______ descent

Neuroblastoma is associated with ______, _____, and _______ aka _______

Opsoclonus-myoclonus ataxia (OMA) is ______, ______, +/- ______. 50% of patients who present with OMA have ________

Infratentorial or _______ brain tumors occur in the _______ / _______

Supratentorial brain tumors occur in the _______, _____, ______, _____, & ______ or ______

Retinoblastoma is a neoplasm of the retinal cells that can extend into the ______; It accounts for ____ to ___ % of childhood cancers. Commonly metastasizes to the ____, ____, & _____

Retinoblastoma is associated with _____; 2/3rds of cases are kids ____ y.o; 95% diagnosed by _____ y.o

Hepatoblastoma is the most common liver mass in children. An elevated _______ is present in 90% of children

Many chemotherapy agents are considered _______ , so a baseline _______ is indicated along with interval checks

Iron overload has been reported in patients following chemotherapy and hematopoietic stem cell transplant. A prolonged elevated ferritin level can lead to

Mucositis can be a severe complication of an immunocompromised state and in the preparation process for stem cell transplant, due to the increased doses of chemotherapy and radiation. The most important prevention method is

The most sensitive scan to detect a new soft tissue mass in a previously radiated site is _______.

A PET scan is a nuclear medicine imaging technique that uses tracers to indicate ________. It can identify _____