1Eukaryotic Cell Cycle
Every cell orginates from another cell
2cell cycle
the highly ordered sequence of events that takes place in a cell, resulting in division of
the nucleus and the formation of two genetically identical daughter cells
3Humans have how many chromosomes?
46 (23 pairs)
4Autosomes in humans
22 pairs
5sex chromosomes
X and Y chromosomes.
6Polidy
number of sets of chromosomes
7Diploid
2 sets of chromosomes
8Haploid
An organism or cell having only one complete set of chromosomes.
9Homologs
Members of a pair of chromosomes
10Autosomes
Any chromosome that is not a sex chromosome
11Sister chromatids
Replicated forms of a chromosome joined together by the centromere
12homologous chromosomes
Pair of chromosomes that are the same size, same appearance and same genes.
13Stages of the cell cycle
G1, S, G2, M, G0
17M
mitosis and cytokinesis
18G0
substitutes for G1 for cells postponing division or never dividing again
19Phases of interphase
G1, S, G2
20G1 Phase
stage of interphase in which cell grows and performs its normal functions, 46 chromosomes
21S Phase
Chromosome is replicated to form Sister chromatids
22G2
the cell synthesizes proteins for cell division
23M Phase
mitosis and cytokinesis
24Mitosis
Separation of sister chromatids
25Cytokinesis
division of the cytoplasm
26Cyclin or Cyclin dependent Kinase are responsible for
advancing cells through phases of cell cycle
27cell cycle checkpoints
critical point in cell cycle that is regulated
283 checkpoints in eukaryotes
G1, G2, Metaphase
29Checkpoint proteins
sensors that determine if the cell is in proper condition to divide
30GI checkpoint
Determines if conditions are favorable for cell division by sensing DNA damage
31G2 checkpoint
Ensures that all DNA is replicated and monitors proteins needed to advance to M
32M checkpoint
cell monitors spindle formation and attachment to kinetochores
33miotic cell division
produces two daughter cells from an original somatic cell, asexual reproduction
34Mitosis steps
prophase, prometaphase, metaphase, anaphase, telophase, cytokinesis
35miotic spindle
a football-shaped structure of microtubules that guides the separation of the two sets of daughter chromosomes
36Prophase
Joined sister chromatids formed and nuclear membrane disassociates
37Prometaphase
Nuclear envelope breaks down and Miotic spindle is formed
38Metaphase
Pairs of sister chromatids are aligned along a plane halfway b/t poles called the metaphase plate
39Anaphase
the third phase of mitosis, during which the chromosome pairs separate and move toward opposite poles
40Telophase
chromosomes move to opposite ends of the cell and two nuclei are formed.
41cytokinesis in plant cells
cell plate forms
42cytokinesis in animals
Actin helps the cleavage furrow form
43Meiosis
The process by which haploid cells are produced from a cell that was originally a diploid
44How many rounds of division are in meiosis?
two
45Bivalet/tetrad
Homologous pairs of sister chromatids associate with each other through synapsis
46Synaptonemal complex
proteins that hold together homologous chromosomes
47crossing over
Process in which homologous chromosomes exchange portions of their chromatids during meiosis.
48Chiasma
arms of the chromosomes tend to separate but remain adhered at a crossover site
49Meiosis 1 stages
prophase 1, metaphase 1, anaphase 1, telophase 1 and cytokinesis
50Prophase 1
Crossing over occurs
51Prometaphase 1
spindles attach to kinetochores on chromosomes
52Metaphase 1
Paired homologous chromosomes line up across the center of the cell
53# of different random alignments in metaphase 1
2^n n= # of chromosome per set
54Anaphase 1
Homologous chromosomes separate
55Telophase 1
A nuclear membrane forms around each cluster of chromosomes on each pole
56End of meiosis 1
two haploid cells, with no pairs of homologous change
57Meiosis II is similar to mitosis in that
sister chromatids separate. However it is done during anaphase II
58sexual reproduction
requires fertilization event in which two haploid gametes unite to create a diploid cell called a zygote
59asexual reproduction
A reproductive process that involves only one parent and produces offspring that are identical to the parent.
60Disadvantages of sexual reproduction
It costs energy
61Advantages of sexual reproduction
genetic variation
62Diploid dominant
Mostly animal species and are specialized cells
63haploid-dominant
Many fungi and some protists
64Inheritance
The acquisition of traits by their transmission from parents to offspring
65blending inheritance
1700s hypothesis that suggested genetic material of two parents blended together in offspring
66particulate inheritance
19th century hypothesis that determined hereditary traits are transmitted in discrete units or particles from one generation to the next
67Gregor Mendel
Priest that experimented with pea plant characters and traits
68Advantages properties of the garden pea
Genetic variation, self fertilization, hybridization
69Characters
General features of an organism
70Trait
Identifiable characteristic of an organism
71self-fertilization
fertilization in which both female and male gamete come from the same plant
72true-breeding lines
Exhibition of the same trait over several generations of self fertilization
73Procedure for Cross fertilization
1. Pollen from one plant is placed on the stigma of flower from a different plant
2. Prying open an immature flower and removing stamens
3. Take pollen from another flower's stamens and place on the stigma
74single-factor cross
Crossing with respect to a single trait
75P generation
true-breeding parents
76F1 generation
offspring of the P generation, mono hybrids if parents differ in one trait
77F2 generation
offspring of the F1 generation, recessive trait appears.
78Mendel results of single factor cross
P gen: crossed tall and dwarf plants
F1 gen: all were tall
F2 gen: dwarf trait appeared. 3/4 plants were tall, 1/4 plants were dwarf
79dominant trait
Displayed in hybrids
81Particulate factors of inheritance
Genes
82Alleles
Different forms of a gene
83Segregation of alleles
Alleles separate and move into different haploid gamete sex cells
84Mendel's law of segregation
Allen's of the same gene separate during game formation
85Only___ allele is received per gene
1
86Genotype
The genetic composition of an individual
87Homozygous
Having two identical alleles for a particular gene
88Heterozygous
An organism that has two different alleles for a trait
89Phenotype
physical characteristics of an organism
90Two factor Cross
a cross in which an experimenter follows the outcome of two different traits
91Patterns of Two-factor Cross
Two genes are liked or two gene are independent
92linked genes
Variants found together in parents that are always inherited as a unit. Produces YR or yr gametes
93independent genes
Variants are randomly distributed, produces YR, Yr, yR, or yr gametes
94Two factor cross outcome
F1: dihybrid offspring
F2: hybrids with independent assortment
95Mendel's Law of independent assortment
Alleles of different genes sort independently of each other during the process that gives rise to gametes
96When do genes not assort independently?
Allele of two genes located near each other on the same chromosome do not assort independently
98Genes are found in
chromosomes
99Chromosomes are passed
From parent to offspring and cell to cell
100During the formation of haploid cells, chromosomes separate ____ from each other
Independently
101locus
the physical location of a gene on a chromosome
102Probability
The chance that an event will have a particular outcome
103Product Rule
The probability that two or more independent events will occur is equal to the product of their individual probabilities
104XY system of sex determination (Mammals)
Males XY and females XY
105XO system of sex determination (Insects)
Females XX and Males X or XO
106ZW system (Birds and Fish)
Males ZZ and females ZW
107X-linked trait
trait controlled by a gene located on the X chromosome
108Males are _____ for X-linked genes
hemizygous
109Simple Mendelian Inheritance
one trait is completely dominant over the other
110Pleiotropy
The ability of a single gene to have multiple effects.
111Incomplete dominance
heterozygous phenotype that is a blend of the two homozygous phenotypes
112Codominance
A condition in which both alleles for a gene are fully expressed
113In a phenotype the environment
Provides nutrients and energy to carry out the plan
114Norm of reaction
phenotype range that individuals with a particular genotype exhibit under differing environmental conditions
115Discrete traits
clearly defined phenotypic variants
116Quantitative traits
traits that show continuous variation (most traits, i.e.: height, intelligence, athleticism)
117Polygenic
multiple genes contribute to phenotype