1The Zona glomerulosa (ZG) of the adrenal cortex secretes __________, which stimulates Na+ retention and K+ excretion.
aldosterone
2The Zona fasciculata (ZF) secretes __________, a glucocorticoid that increases blood glucose and provides adaptation to stress.
cortisol
3The Zona reticularis (ZR) of the adrenal cortex secretes male __________.
sex steroids
4The adrenal medulla secretes epinephrine and __________ to prepare the body for the fight-or-flight response.
norepinephrine
5Cushing's syndrome is an endocrine abnormality caused by __________ levels of glucocorticoids.
elevated
6Addison's disease is an endocrine abnormality caused by __________ levels of glucocorticoids.
reduced
7Thyroid follicles produce hormones derived from the protein precursor __________.
thyroglobulin
8The thyroid gland secretes thyroxine (T4) and __________, which is the more active of the two hormones.
triiodothyronine (T3)
9The numbers 4 and 3 in T4 and T3 refer to the number of __________ atoms in these hormones.
iodine
10Decreased amounts of T4 during early development can lead to __________, a form of severe cognitive and physical impairment.
cretinism
11Deficiency of T4 in adults is called __________, while overproduction of T4 is called hyperthyroidism.
hypothyroidism
12Low levels of thyroid hormones remove negative feedback on the anterior pituitary, causing excess TSH secretion and thyroid enlargement known as a __________.
goiter
13Calcitonin (CT) is produced by __________ cells located outside of the thyroid follicles.
parafollicular
14Calcitonin acts to __________ blood Ca2+ levels by promoting deposition in bone and increasing kidney excretion.
decrease
15Parathyroid hormone (PTH) is produced by four parathyroid glands embedded in the back of the __________ gland.
thyroid
16PTH increases blood Ca2+ by inhibiting kidney excretion, stimulating bone breakdown, and increasing absorption in the small intestine via Vitamin __________.
D3
17Hormone-secreting cells in the endocrine pancreas are clustered within the __________ of Langerhans.
islets
18Beta cells of the endocrine pancreas secrete __________, which decreases blood glucose levels.
insulin
19Type I Diabetes Mellitus is caused by autoimmune destruction of beta cells leading to insulin __________.
deficiency
20Type II Diabetes Mellitus is characterized by defective insulin receptors or post-receptor signaling, leading to insulin __________.
resistance
21A hallmark metabolic symptom of Type I DM is the buildup of __________ in the blood (ketosis) and urine (ketonuria) from increased fat breakdown.
ketones
22Alpha cells of the endocrine pancreas secrete __________, which raises blood glucose in response to low blood sugar during fasting.
glucagon
23Glucagon and insulin have __________ physiological effects on blood glucose regulation.
antagonistic
24The pineal gland secretes __________, a hormone produced at night and inhibited by light.
melatonin
25Melatonin secretion is regulated by the __________ nuclei (SCN) via sympathetic neurons.
suprachiasmatic
26Melatonin is synthesized from the amino acid precursor __________.
tryptophan
27Shift work and jet lag disrupt the timing and pattern of melatonin secretion, affecting 24-hour __________ rhythms.
circadian
28Seasonal Affective Disorder (SAD) is characterized by winter depression and __________ craving.
carbohydrate
29Atrial natriuretic peptide (ANP) is secreted by the atria of the __________ in response to increased blood volume.
heart
30ANP acts on the kidneys to increase the excretion of __________ and water.
sodium (Na+)
31Erythropoietin (EPO) is produced by the __________ in response to decreased oxygen levels in the blood.
kidneys
32EPO acts on the __________ to stimulate red blood cell (RBC) production.
bone marrow
33White adipose tissue secretes __________, which acts as a metabolic signal to the brain to reduce appetite.
leptin
34Skin produces Vitamin D3, which is derived from a form of __________.
cholesterol
35The placenta secretes human __________ gonadotropin (hCG), which is measured clinically to confirm pregnancy.
chorionic
36Placental lactogen (PL) stimulates the growth and development of __________ glands for postpartum lactation.
mammary
37An increase in blood osmolality triggers the posterior pituitary to release __________ (ADH), which targets the kidneys to decrease urine production.
antidiuretic hormone
38Suckling or baby head pressure on the cervix triggers the posterior pituitary to release __________, causing uterine contractions and milk let-down.
oxytocin
39High blood Ca2+ stimulates parafollicular cells to release calcitonin, which promotes Ca2+ deposition in __________.
bone
40Low blood Ca2+ stimulates the parathyroid gland to release __________, which increases Ca2+ reabsorption in the kidneys.
PTH (Parathyroid Hormone)
41Decreased blood glucose stimulates alpha cells to release glucagon, which targets the liver, muscle, and __________ tissue.
fat (adipose)