1The presence of the __________ gene on the Y chromosome leads to the expression of Testis-Determining Factor (TDF).
SRY
2In male embryonic development, testosterone stimulates the development of the __________ ducts into internal male reproductive structures.
Wolffian
3The enzyme __________ converts testosterone into dihydrotestosterone (DHT), which drives the development of male external genitalia.
5-alpha reductase
4The enzyme __________ converts testosterone into estradiol in certain tissues like the brain and adipose tissue.
aromatase
5Spermatogenesis occurs within the __________ tubules of the testes.
seminiferous
6__________ cells in the testes form the blood-testis barrier to protect developing germ cells from immune attack.
Sertoli
7Sertoli cells secrete __________-inhibiting factor (MIF) during embryonic development to regress female reproductive ducts.
Müllerian
8Sertoli cells secrete the hormone __________, which selectively inhibits FSH secretion from the anterior pituitary.
inhibin
9Sertoli cells produce Androgen-Binding Protein (ABP) to concentrate __________ within the seminiferous tubules.
testosterone
10Intercellular Leydig cells in the testes synthesize and secrete __________ in response to LH stimulation.
testosterone
11Sperm undergo final maturation and storage in the __________, located on the posterior exterior of each testis.
epididymis
12Erection of the penis is mediated by the autonomic nervous system via the release of __________ oxide, causing vascular smooth muscle relaxation.
nitric
13The __________ glands and seminal vesicles secrete alkaline fluids rich in fructose to nourish sperm and neutralize vaginal acidity.
prostate
14Androgens stimulate red blood cell production by increasing the kidney secretion of __________, leading to higher hematocrit in males.
erythropoietin (EPO)
15The __________ provides a temperature-controlled environment for the testes, keeping them about 2-3°C cooler than core body temperature.
scrotum
16GnRH is released from the hypothalamus in a __________ manner to maintain sensitivity of pituitary gonadotropes.
pulsatile
17Luteinizing Hormone (LH) directly targets __________ cells in the testes to stimulate testosterone synthesis.
Leydig
18Follicle-Stimulating Hormone (FSH) directly targets __________ cells in the seminiferous tubules to support spermatogenesis.
Sertoli
19Elevated plasma testosterone exerts negative feedback on both the hypothalamus (inhibiting GnRH) and the anterior pituitary (inhibiting __________).
LH
20The hormone __________ from the anterior pituitary can enhance LH receptor sensitivity in Leydig cells, but excess levels cause reproductive dysfunction.
prolactin
21In the absence of a Y chromosome and SRY gene, the __________ ducts automatically develop into female internal genitalia.
Müllerian
22Developing female embryos are protected from brain masculinization by maternal estrogen through binding to alpha-__________ protein.
fetoprotein
23Fertilization of the secondary oocyte typically occurs in the ampulla region of the __________ tubes.
uterine (Fallopian)
24The inner mucosal lining of the uterus that undergoes monthly shedding and proliferation is the __________.
endometrium
25The female erectile organ homologies to the male penis is the __________, which develops from the genital tubercle.
clitoris
26Primary oocytes remain arrested in __________ of meiosis I from birth until puberty.
prophase
27Prior to ovulation, the primary oocyte completes meiosis I to form a secondary oocyte and a non-functional first __________ body.
polar
28The secondary oocyte arrests in __________ of meiosis II and only completes meiosis if fertilization occurs.
metaphase
29External factors such as severe psychological stress, low body fat percentage, or excessive exercise can cause functional hypothalamic __________.
amenorrhea
30The first half of the ovarian cycle, characterized by follicle growth driven by FSH, is called the __________ phase.
follicular
31A sharp rise in plasma __________ produced by the dominant follicle triggers a positive feedback surge of LH.
estradiol (estrogen)
32The mid-cycle surge of __________ Hormone directly triggers ovulation and luteinization of the ruptured follicle.
Luteinizing (LH)
33Following ovulation, the remnants of the ruptured follicle transform into the __________ luteum.
corpus
34The corpus luteum secretes high amounts of __________, which transforms the endometrium into a glandular, secretory phase.
progesterone
35The uterine phase that coincides with the ovarian luteal phase is called the __________ phase.
secretory
36If fertilization does not occur, the degeneration of the corpus luteum causes a rapid drop in estrogen and progesterone, triggering __________.
menstruation
37Combination oral contraceptives prevent pregnancy primarily by maintaining steady synthetic steroid levels that suppress the mid-cycle __________ surge.
LH
38__________ is defined as the permanent cessation of menstrual cycles due to depletion of functional ovarian follicles.
Menopause
39During menopause, ovarian estrogen secretion declines drastically, causing a reflex __________ in circulating pituitary LH and FSH levels.
increase