1Behavioural responses
Muscular movements that are appropriate to the situation.
2Autonomic responses
Responses that facilitate quick reactions and energy for vigorous movement.
3Hormonal responses
Responses that reinforce the autonomic responses.
4Right ventral medial prefrontal cortex (vmPFC)
A brain region whose damage impairs people's ability to understand and be amused by jokes; it is activated by all types of jokes. It is also involved in conditioned responses related to learned fear or relaxation.
5Nucleus accumbens
A brain region activated by funny socially appropriate jokes, associated with reinforcement and reward.
6Right amygdala
A brain region activated by jokes that violate social norms. It shows the largest response when shown fearful faces and exhibits activity before the visual cortex does in response to such faces. It directs/allocates resources to coordinate emotional responses. Damage to this area can lead to reduced sensitivity to fear and impaired ability to recognize facial expressions of emotion, especially fear.
7Left orbital frontal cortex
A brain region activated by jokes that violate social norms.
8Insular cortex
A brain region whose damage impairs people’s ability to recognize facial expressions of disgust. It is activated by smelling bad odor and seeing a face of a person expressing disgust. Damage to its white matter is associated with emotional facial paresis.
9Basal ganglia
Brain structures whose damage impairs people’s ability to recognize facial expressions of disgust.
10Fight or flight
An emotional response involving increased heart ratelood pressure, increased respiration, increased vigilance, and cortical activation between visual, motor, auditory, and sensory mediators.
11Prefrontal cortex (vmPFC)
Involved in conditioned responses (learned fear or relaxation) and classical conditioning. Comprehension of emotion from word meaning increases its activity.
12Urbach-Wiethe disease
A genetic disorder characterized by increased collagen, leading to reduced sensitivity to fear, often due to amygdala damage.
13Serotonin
A neurotransmitter involved in the heritability of serotonin signaling and aggression genes. Serotonergic neurons play an inhibitory role in human aggression. Reduced levels are associated with aggression and antisocial behavior.
14Tryptophan hydroxylase
An enzyme involved in serotonin synthesis.
15Serotonin receptors
Proteins on neurons that bind to serotonin.
16Serotonin transporters
Proteins that regulate the movement of serotonin.
17Monoamine oxidases
Enzymes that inactivate serotonin.
18Serotonin agonists
Substances that might help reduce aggressive behavior, such as fluoxetine.
19Testosterone
A hormone that contributes to male aggression; natural hormonal changes during puberty can lead to higher confidence and violence.
20Hypothalamic Pituitary Adrenal Axis
An interaction between the hypothalamus, the pituitary gland, and the adrenal cortex involved in the stress response and the secretion of hormones related to stress, anger, aggression, "fight," and suppressing anger.
21Cortisol
A hormone secreted as part of the stress response that suppresses testosterone but contributes to anxiety and distress.
22Aggression displacement
A concept related to a high aggressive drive together with personality factors.
23Hypo-arousal-associated aggressiveness
Aggressiveness linked to glucocorticoid deficiency, seen in antisocial personality disorder.
24Hyper-arousal-driven aggressiveness
Aggressiveness associated with an acute exaggerated glucocorticoid response to stress (can be seen in PTSD) and intermittent explosive disorder.
25Glucocorticoid deficiency
A condition linked to hypo-arousal-associated aggressiveness.
26PTSD
Post-traumatic stress disorder, which can be associated with hyper-arousal-driven aggressiveness.
27Intermittent explosive disorder
A condition that can be associated with hyper-arousal-driven aggressiveness.
28Lateralization
The idea that the right hemisphere has more of a role than the left hemisphere in the comprehension of emotion. Right hemisphere lesions impair the expression of emotion (facially and in tone of voice).
29Functional Neurological Disorder/Conversion Disorder
A condition where signs and symptoms affecting sensory/motor function are inconsistent with patterns of known neurological diseases, significantly impacting function and not controlled at will or feigned intentionally.
30Auditory cortex
The part of the brain connected to the cochlea that perceives loudness and maintains tonotopic information.
31Cochlea
A part of the auditory system that perceives loudness and contains a frequency map on its basilar membrane.
32Basilar membrane
A structure in the cochlea that has a frequency map where different parts respond to different frequencies.
33Tonotopic information
The organization of auditory information based on frequency.
34Retinotopic information
The organization of visual information based on its origin on the retina.
35Extrastriate cortex
The region surrounding the primary visual cortex, also known as V2.
36Striate cortex
The primary visual cortex (V1) located in the occipital lobe.
37Dorsal stream
The "where" pathway in the visual system that ends in the parietal cortex.
38Parietal cortex
The brain area where the dorsal stream of visual processing ends, involved in spatial perception.
39Ventral stream
The "what" pathway in the visual system that ends in the temporal cortex.
40Temporal cortex
The brain area where the ventral stream of visual processing ends, involved in object recognition.
41Visual agnosia
The inability to identify objects by sight due to damage to the ventral stream.
42Prosopagnosia
The inability to recognize faces while still perceiving facial features.
43Anterior fusiform gyrus
A brain region that is smaller in individuals with congenital prosopagnosia.
44Stepitosis
Damage to the eardrum causing trouble identifying volume and directionality of sound.
45Rods
Photoreceptor cells involved in vision under low light conditions.
46Cones
Photoreceptor cells responsible for color vision.
47Lateral geniculate nucleus (LGN)
A nucleus where neurons in the visual pathway send axons to V1.
48Optic radiations
Axons from LGN neurons that project to the primary visual cortex (V1).
49V1
The primary visual cortex, also known as the striate cortex.
50Occipital lobe
The brain lobe where the primary visual cortex (V1) is located.
51V2
The second cortical area for visual processing, also known as the extrastriate cortex.
52Vestibular sacs
Structures that respond to gravity and inform head orientation.
53Vestibular nerve
A nerve connected to the vestibular sacs.
54Semi-circular canals
Structures that respond to angular acceleration and changes in position.
55Vestibular Pathway
A sensory pathway integrating information from the somatosenses.
56Cranial Nerves
Nerves that provide individualized connections to senses.
57Somatosenses
Bodily senses, with skin senses (cutaneous) being the most studied.
58Cutaneous
Relating to the skin senses.
59Skin
The outer layer of the body containing different sensory receptors.
60Subcutaneous tissue
The layer beneath the skin.
61Dermis
A middle layer of the skin.
62Epidermis
The outermost layer of the skin.
63Encapsulated somatosensory receptors
Sensory receptors located throughout the skin layers.
64Merkel’s Disks
Receptors in hairy and glabrous skin that detect form and roughness.
65Ruffini corpuscles
Receptors that detect static force, skin stretching, and proprioception.
66Meissner’s corpuscles
Receptors in glabrous skin that detect edge contours and braille-like stimuli.
67Pacinian corpuscles
Receptors that detect vibration and information from held objects.
68Proprioception
The sense of body position in space.
69Kinesthesia
The sense of body movement through space.
70Stretch receptors
Receptors in skeletal muscles that report changes in muscle length.
71Thermal receptors
Free nerve-ending receptors that respond to warmth and cold.
72TRPV1
A receptor that responds to heat (43°C+) and burning pain.
73TRPV2
A receptor that responds to noxious heat (52°C+).
74TRPV3
A receptor that responds to warmth (31°C+).
75TRPV4
A receptor that responds to warmth (25°C+).
76TRPM8
A receptor that responds to coolness (<28°C), such as menthol.
77Nociceptors
Pain receptors that detect noxious stimuli.
78TRPA1
A receptor sensitive to pungent irritants and environmental toxins.
79High-pressure mechanoreceptors
Free nerve endings that detect intense pressure and act as pain receptors.
80Olfactory receptor cell
A neuron that sends an axon to the olfactory bulb.
81Olfactory bulb
A structure where olfactory receptor cells synapse with mitral cells.
82Mitral cells
Neurons in the olfactory bulb that receive input from olfactory receptor cells.
83Amygdala
A brain region receiving olfactory information and sending it to the hypothalamus.
84Hypothalamus
A brain region involved in food acceptance or rejection based on olfactory input.
85Entorhinal cortex
A brain region that sends olfactory information to the hippocampus.
86Hippocampus
A brain region that receives olfactory input from the entorhinal cortex.
87Piriform cortex
A brain region involved in odor recognition and processing.
88Orbitofrontal cortex
A brain region that receives olfactory information from the piriform cortex.
89Dorsomedial nucleus of the thalamus
A nucleus that relays olfactory information to the hypothalamus and orbitofrontal cortex.
90Olfactotopic information
The organization of olfactory information based on odor.
91Synesthesia
A condition where one sensory input triggers an experience in another sensory modality.
92Autism Spectrum Disorder (ASD)
A developmental disorder with sensory dysfunction as a key characteristic.
93Sensory Processing Disorder
A condition where multisensory input is improperly processed.
94Sensory Modulation Disorder
A type of sensory processing disorder affecting responsiveness to sensory stimulation.
95Hyporesponsitivity
A state requiring intense sensory stimulation to elicit a response.
96Hyperresponsivity
A state where innocuous stimuli are perceived as extreme or threatening.
97Central Auditory Processing Disorder (CAPD)
A disorder affecting sound localization, discrimination, and pattern recognition.
98ADHD
A developmental disorder with inattention and hyperactivity, often with sensory dysfunction.
99Tourette
A neurological disorder where individuals with ASD and ADHD have similar sensory symptoms.
100Symptoms of Functional Neurological Disorder
Swallowing, Speech, Myoclonus (spastic movement), Sensory loss
101First step of treatment for FND
Effective presentation of diagnosis