ACADEC Science

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1
5-HT (5-hydroxytryptamine)
neurotransmitter that is also known as serotonin; notable for its function in mood and emotion aka serotonin
2
Absolute refractory period
the interval of time immediately following an action potential during which a second action potential cannot be initiated, as the voltage-gated sodium channels have not returned to their closed state and are not ready to be opened again
3
Absorption spectra
the specific wavelengths of light absorbed by a particular substance; in neuroscience, this refers to the opsins found in cone photoreceptors, each of which absorbs and transduces a different wavelength of light.
4
Action potential
the basic event nerve cells use to transmit information from one place to another; a brief and drastic change in the membrane potential of a neuron, caused by the rapid opening and closing of ion channels
5
Active transport
the movement of molecules or ions across a cell membrane from a region of lower concentration to a region of higher concentration, meaning against the concentration gradient; energy is required to achieve this movement.
6
Active zone
the site of neurotransmitter release
7
Afferents
nerves/axons that bring information to the central nervous system or brain
8
Afterhyperpolarization
the phase of a neuron's action potential when the cell's membrane potential falls below the normal resting potential; commonly referred to as the undershoot phase
9
Agonist
a substance that binds to a receptor and causes the same action as the substance that normally binds to the receptor
10
Akinetopsia
a condition defined by the inability to detect motion
11
All-or-none principle
This principle refers to the fact that a nerve signal is sent at the same intensity regardless of the intensity of the initial impulse as long as an initial threshold is met, and thus the neuron fires at full strength or not at all.
12
Allosteric site
a binding site on a protein where molecules can bind that is different from the main binding site that the usual binding partner uses (used by non-competitive agonists and antagonists)
13
AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor
a type of ionotropic receptor for glutamate that allows sodium influx, depolarizing the cell and mediating excitatory neurotransmission
14
Amygdala
a subcortical structure in the temporal lobe of the brain that is associated with regulating emotion; a major component of the limbic system
15
Antagonist
a substance that prevents the binding or the action of a substance that normally binds to a receptor
16
Anterolateral spinothalamic system
one of the ascending systems that brings sensory information from the body to the brain (specifically, pain and temperature)
17
Arachnoid membrane
the middle layer of the three protective membranes (meninges) that cover the brain and spinal cord; characterized by long, stringy components that look like spider webs
18
Area MT
a region in the parietal lobe of the cortex that is involved with motion perception
19
Artificial intelligence
computer systems that are able to perform tasks that typically require human intelligence
20
Artificial neural networks
Developed to allow computers to mimic existing networks of neurons in the brain, these networks involve layers of nodes that are analogous to neurons.
21
Astrocyte
a large, star-shaped glial cell in the brain that supports neurons and regulates the extracellular environment; astrocytes form part of the blood-brain barrier.
22
Autonomic nervous system
a component of the peripheral nervous system that regulates involuntary physiologic processes, including heart rate, blood pressure, respiration, digestion, and sexual arousal
23
Axon
a long cord-like portion of the neuron's structure that conducts electrical impulses or action potentials away from the cell body
24
Axon hillock
the site of transition between the cell body and the axon; controls the initiation of an electrical impulse
25
Axon terminal
the end region of an axon that contains neurotransmitters for neural communication
26
Barrel field
an area of a rodent's primary somatosensory cortex representing the touch or somatosensory inputs of each of their whiskers
27
Basal ganglia
a cluster of nuclei deep in the cerebral hemispheres of the brain that is critical for voluntary bodily movement and motivation
28
Basilar membrane
the flexible membrane inside the cochlea where auditory transduction takes place, which encodes the frequency or pitch of a sound based on its position along the membrane
29
Binocular vision
vision that incorporates inputs from both eyes into a single image
30
Bipolar cells
cells that connect photoreceptors to ganglion cells in the retina
31
Blood brain barrier
a highly selective lining of the blood vessels in the brain that keeps certain molecules or infectious agents from gaining access to the central nervous system
32
BOLD imaging
a mechanism that functional MRI (fMRI) uses to record neural activity by tracking oxygenated blood flow in the brain; BOLD is an acronym for Blood Oxygen Level Dependent.
33
Brain-machine interface (BMI)
a system that allows a person to control a device or machine with their own brain by way of implanted electrodes
34
Brainstem
a stalk-like structure that connects the brain to the spinal cord; regulates many of the body's critical functions, including breathing, heart rate, coordination, and reflexes
35
Calcium calmodulin-dependent protein kinase (CaMKII)
a protein kinase activated by an increase in internal Ca2+ concentration; involved in several mechanisms that result in LTP
36
Center-surround receptive field
a visual receptive field with a circular center region and a surround region; stimulation of the center produces a response opposite of the response generated by stimulation of the surround.
37
Central canal
a narrow tube through the length of the entire spinal cord that contains the cerebrospinal fluid (CSF); part of the ventricular system
38
Central nervous system (CNS)
the part of the nervous system that is encased in bone; made up of the brain and spinal cord
39
Cerebellar deep nuclei
nuclei found deep within the cerebellum that provide the output from this structure
40
Cerebellum
a structure at the rear of the brain that is responsible for controlling balance and other complex motor functions
41
Cerebral aqueduct
a conduit that allows cerebrospinal fluid to flow between the third and fourth ventricle of the brain; part of the ventricular system
42
Cerebral cortex
the outermost, wrinkly layer of the brain that plays an important role in memory, thinking, learning, reasoning, problem-solving, emotions, consciousness, and functions related to the senses
43
Cerebral hemispheres
each of the two parts of the cerebrum (left and right) in the brain
44
Cerebrospinal fluid (CFS)
fluid that cushions and protects the brain; produced by the choroid plexus; flows through the ventricular system to the subarachnoid space
45
Cervical spinal cord
the top section of the spinal cord that carries information to and from (innervates) the arms, neck, and shoulders
46
Channel
an opening or passageway for an ion to pass from one side of a membrane to the other
47
Channelrhodopsin-2 (ChR2)
a light-sensitive cation channel, which was originally isolated from green algae; can be artificially expressed in neurons and then used to control the activity of that neuron using specific wavelengths of light
48
Chemical driving force
a force that is a result of an ion concentration gradient across the cell membrane,
49
Chemical synapses
a type of synapse in which presynaptic activity stimulates the release of neurotransmitters, activating receptors in the postsynaptic membrane
50
Choroid
a network of blood vessels located between the sclera and the retina; brings oxygen and nutrients to the retina
51
Choroid plexus
a network of blood vessels in each ventricle of the brain that produce the cerebrospinal fluid
52
Classical conditioning
a learning procedure in which a stimulus that evokes a response is paired with another neutral stimulus that normally does not evoke this response; an association between these stimuli is then learned.
53
Cochlea
the section of the inner ear where auditory transduction takes place, translating sound waves into electrochemical signals
54
Competitive agonist
a substance that competes for the same receptor binding site as the endogenous neurotransmitter
55
Competitive antagonist
a molecule that competes for the same binding site as the natural (endogenous) neurotransmitter and has the opposite effect as that transmitter
56
Computational neuronal modeling −
the use of computer algorithms to model the behavior of neurons to learn more about their processes
57
Computational psychiatry
a field of psychiatry that uses computer algorithms in behavior testing to provide clinicians with more data about psychiatric patients and gather insight about the effect of treatments
58
Concentration gradient
the difference in concentration of a substance between one location and another
59
Cone
a photoreceptor type concentrated in the fovea of the retina; specialized for daytime vision and responsible for color vision
60
Conformation
the shape of a receptor
61
Congenital analgesia
insensitivity to pain, or pain blindness, present from birth
62
Connectome
a map of the neural circuit structure and function within the human brain
63
Consolidation
the process by which recent learned experiences are transformed into long-term memory
64
Cornea
the transparent external surface of the eye that is responsible for the majority of the refraction (bending/focusing) of light
65
Cortical magnification
the effect created by the number of neurons in the visual cortex varying as a function of the location of the stimulus in the visual field; items appearing in the central part of the visual field are represented larger in the visual cortex than objects at the edge of the visual field.
66
Corticospinal tract
one of the descending motor pathways bringing motor information down from the brain to the muscles (specifically, voluntary movement commands for most parts of the body, including limbs and digits)
67
Cranial nerves
twelve pairs of nerves entering or exiting the brain at the brainstem that connect the central nervous system with the head, face, and neck
68
CREB
a transcription factor that is critical in producing new proteins necessary for maintaining structural changes in the synapse; activated by CAMKII
69
Cribriform plate
the part of the skull that divides the brain and olfactory bulb from the sinuses; contains tiny holes for olfactory axons to pass through, carrying smell information to the brain
70
Critical periods
limited periods of time when an aspect of brain development is particularly sensitive to inputs from the external environment
71
DAG (diacylglycerol)
a secondary messenger that activates the enzyme protein kinase C and is involved in many signaling cascades
72
Decussation
the crossing of nerve pathways from one side of the nervous system to the other
73
Deep neural network
a complex version of an artificial neural network that is capable of highly advanced problem solving
74
Degenerate
to lose structure or function
75
Delayed rectifier
a voltage-gated potassium channel named for its delay in returning the neuron membrane potential to rest following afterhyperpolarization
76
Dendrite
a projection of a neuron that receives signals from other neurons
77
Dendritic arbor
the size and shape of the branching dendrites from one neuron
78
Dentate gyrus
a region of the hippocampus that is notable for evidence of neurogenesis in adults
79
Deoxygenated
not carrying oxygen
80
Depolarization
a change in the membrane potential that takes it from the value at rest to a less negative (more positive) value
81
Dermatome
an area or stripe of skin whose neurons all send their input to the brain via the same spinal nerve and have their cell bodies in the same dorsal root ganglion
82
Diffuse
to move from a region of high concentration to low concentration, resulting in a more even distribution of a given ion
83
Dipole
an area of negative charge next to an area of positive charge
84
Direction-selective neurons
In the visual system, these neurons fire action potentials maximally when they detect movement in a particular direction.
85
Dopamine
a type of catecholamine (derived from the molecule tyrosine) neurotransmitter that is involved in movement, mood, attention, and internal organ function; produced mainly in the ventral tegmental area and the substantia nigra of the basal ganglia
86
Dopaminergic
describes a cell that produces dopamine
87
Dorsal column medial lemniscal system
one of the ascending systems that brings sensory information from the body to the brain (specifically, fine detailed touch information, vibration, and texture)
88
Dorsal root ganglion
the part of the spinal nerves that contains the cell bodies for somatosensory neurons bringing information from the skin and tissues to the brain
89
Dura mater
the tough, outermost layer of the three protective membranes (meninges) that cover the brain and spinal cord
90
Effector protein
selectively binds to a protein to regulate its biological activity; can alter enzyme activity, gene expression, or other protein functions
91
Efferents
nerves/axons that bring information down from the central nervous system or brain
92
Efflux
flow out of a cell
93
Electrical brain stimulation (EBS)
the implantation of an electrode in the brain to stimulate specific neurons, neural networks, or brain regions in order to study the function of the cerebral cortex
94
Electrical driving force
the force created by the separation of charge across the membrane; tends to move ions in a direction determined by its charge, as like charges repel and opposite charges attract
95
Electrical potential
the force exerted on an electrically charged particle; represented by the symbol V and measured in volts; also called voltage or potential difference
96
Electrical synapses
synapses in which electrical current flows directly from one cell to another via a junction that allows ions to pass directly (gap junction)
97
Electrodes
small, wire-based devices designed to read the electrical signals that the brain uses to process information
98
Electroencephalogram (EEG)
a test that measures electrical activity generated by the brain and recorded from the scalp using electrodes
99
Electrophysiological recordings
recordings of the electrical activity of neurons
100
Endocytosis
a process that brings substances into the cell; material to be internalized is surrounded by an area of cell membrane, which buds off inside the cell to form a vesicle containing the ingested material.
101
Endogenous
naturally occurring
102
Entorhinal cortex
a region of the medial temporal lobe that helps process perceptual and sensory inputs; the source of the majority of inputs to the hippocampus
103
Epidural space
the area between the dura mater and the skull; contains fat and small blood vessels
104
Epinephrine
"a type of catecholamine (derived from the molecule tyrosine) neurotransmitter; also known as adrenaline; plays a key role in mediating the ""fight or flight"" response"
105
Episodic memory
a type of long-term memory that involves the conscious recollection of previous personal experiences/events that can be explicitly stated
106
EPSP
acronym for excitatory postsynaptic potential; refers to the temporary depolarization caused by the flow of positively charged ions into the postsynaptic cell; if the EPSP is large enough or several sum together, an action potential may occur.
107
Equilibrium potential
the potential at which the electrical driving force across the cell membrane exactly balances the chemical driving force; at this point, there is no net movement of ions from one side of the membrane to the other.
108
Event-related potential (ERP)
an electrical potential that directly results from a particular stimulus or event; ERP experiments record EEG activity at a particular time in order to measure the neural response to one event or stimulus.
109
Excitatory
describes a condition or event that makes the neuron more likely to fire an action potential by bringing membrane potential up to or closer to threshold
110
Excitotoxicity
results from too much excitation and prolonged positive membrane potentials and leads to neuronal death
111
Exocytosis
a process by which material is released from an intracellular vesicle into the extracellular space by fusion of the vesicle membrane with the cell membrane
112
Explicit memory
a type of long-term memory involving the recall of previously learned information that requires conscious effort to retrieve
113
Extracellular fluid
fluid outside of the cell
114
Extracellular recording
the measurement of neuronal activity from outside the cell; typically measured either in extracellular fluid near the cell of interest or noninvasively
115
Extrastriate cortex
a region of the occipital lobe surrounding the primary visual cortex that is involved in high-resolution vision and object recognition
116
Falling phase
the part of an action potential that is characterized by a rapid fall of membrane potential from positive to negative; caused by the inactivation of the sodium channels and the opening of the potassium channels
117
Fornix
a projection from the hippocampus that brings information from the hippocampus to a range of deep brain regions; involved in long-term memory encoding and consolidation
118
Fourth ventricle
a diamond-shaped cavity involved in the ventricular system; one of the four cerebrospinal fluid-filled cavities within the human brain
119
Fovea
the central portion of the retina, which contains only cone photoreceptors and is specialized for high acuity vision
120
Frontal lobe
the largest lobe in the human brain; located right behind the forehead, it has many regions that are responsible for complex thinking and cognition.
121
Functional MRI (fMRI)
an imaging technique that monitors oxygenated blood flow changes to estimate the location of neural activity; can be used to create activation maps of which parts of the brain may be involved in a particular task
122
Fusiform face area (FFA)
a small area of the brain found on the lower surface of the temporal lobe that is specifically involved in processing faces
123
G-protein coupled receptors (GPCRs)
membrane proteins or receptors that use G proteins to convert extracellular signals into intracellular responses when bound to a molecule or neurotransmitter; found in many different systems and cell types in the brain
124
GABA (gamma-aminobutryic acid)
− a major inhibitory neurotransmitter in the central nervous system; lessens a neuron's ability to receive, create, or send messages to other nerve cells
125
Ganglia
a collection of nerve cell bodies in the peripheral nervous system that carry signals to and from the central nervous systems
126
Gap Junction
a type of cell junction in which adjacent cells are connected through protein channels; these channels permit the direct cell to cell transfer of ions and small molecules and form the basis of electrical synapses
127
Glabrous
describes skin that is hairless, often with a high concentration of sensory receptors for touch
128
Glia
cells found in the central and peripheral nervous system that provide support and immune protection to neurons
129
Glomeruli
the clusters of nerve endings in the olfactory bulb where olfactory receptor neuron terminals meet the next neuron terminals meet the next neuron in the olfactory system
130
Glutamate
a major excitatory neurotransmitter in the central nervous system; strengthens a neuron's ability to receive, create, or send messages to other nerve cells
131
Goldman Equation
a mathematical relationship used to predict the membrane potential from the concentrations and membrane permeabilities of ions
132
Grey Matter
a generic term for a collection of neuronal cell bodies in the central nervous system; when a freshly dissected brain is cut open, large concentrations of neuronal cell bodies appear gray
133
Gyrus
a ridge on the surface of the brain
134
Habituation
a reduction in the strength of synapses between neurons due to repeated stimulation; this results in decreased behavioral responses
135
Hippocampus
a complex brain structure in the temporal lobe that plays a crucial role in learning and memory
136
Homeostasis
a state categorized by a stable internal environment that relies on many variables such as body temperature being kept within certain pre-set limits by adjusting to changing external conditions
137
Horizontal Cell
a laterally interconnecting cell in the retina of the eye that integrates and regulates input from multiple photoreceptor cells; helps form the center surround receptive fields
138
Hormone
a chemical messenger of the body that circulates in the bloodstream and controls the actions of certain cells or organs
139
Hyperalgesia
increased sensitivity to pain, often caused by inflammation or related damage
140
Hyperpolarization
a change in the membrane potential to a more negative value
141
Hypothalamus
a structure located just below the thalamus in the forebrain that regulates the actions of the pituitary gland and many unconscious functions of the brain that are critical for homeostasis such as body temperature, blood pressure, hunger, thirst, and sleep
142
Implicit memory
a type of long-term memory that is acquired and used unconsciously; accounts for acquired skills and conditioned responses such as riding a bike or tying your shoes
143
Inferior colliculus
a cluster of grey matter found in the brainstem that forms an important relay station for auditory information on its way to the brain
144
Inhibitory
makes a neuron less likely to fire by taking the membrane potential away from threshold
145
Inner hair cells
cells of the inner ear featuring stereocilia, which are long hair-like appendages that are moved back and forth by sound waves to transduce sound
146
Innervate
to connect a structure or region by sending axons to that region
147
Innervated
a structure is innervated by a region if that region supplies it with information
148
Interneurons
neurons found in the central nervous system that communicate with each other, often playing the role of a go-between to connect sensory and motor neurons
149
Intracellular (single unit) recording
the implantation of an electrode into a single neuron to record precise changes in the membrane potential
150
Ion
an atom or molecule with a net positive or negative electric charge
151
Ion channel
a protein that spans the cell membrane, allowing the passage of ions from one side of the membrane to the other
152
Ionic concentration
the number of ions in a defined space
153
Ionotropic receptors
membrane-spanning proteins that have a central pore to allow ions such as Na+, K+, Ca2+, and/or Cl− to pass when a specific chemical or neurotransmitter molecule is bound
154
IP3 (inositol-1,4,5- triphosphate)
− a secondary messenger molecule that causes the release of Ca2+ from internal stores into the cytosol
155
IPSP
an acronym for inhibitory postsynaptic potential; the temporary hyperpolarization of the postsynaptic membrane that is caused by the flow of negatively charged ions into the postsynaptic cell, making it less likely to fire an action potential
156
Iris
the circular, pigmented muscle that controls the size of the pupil in the eye
157
Lateral geniculate nucleus
a multilayered structure in the thalamus that processes visual input and regulates the flow and strength of visual information to the visual cortex
158
Lateral inhibition
the capacity of excited neurons to reduce the activity of their neighbors
159
Lateral ventricles
two C-shaped cerebrospinal fluid- filled cavities, located on the side of each cerebral hemisphere, that participate in the ventricular system
160
Lens
the dynamic, many-layered, clear structure behind the cornea of the eye that works to further refract light to focus an image on the retina
161
Lesion studies
studies conducted by removing or damaging a region/particular cell type in the brain to understand its necessity for a specific behavior
162
Ligand gated
describes a channel or gate that is opened only once the target molecule or neurotransmitter is bound
163
Limbic
relating to emotion
164
Limbic system
a group of structures, including the amygdala, that are anatomically interconnected and support a variety of functions including emotion, learning, and memory
165
Locus coeruleus
a small bundle of neurons found in the pons of the brainstem that can appear bluish; the primary source of norepinephrine (NE); involved in many functions such as regulating mood and attention
166
Long-term depression (LTD)
the weakening of a synaptic connection for an extended period of time, usually due to changes in the postsynaptic receptors
167
Long-term memory
memories that are relatively permanent and do not require continual rehearsal
168
Long-term potentiation (LTP)
the strengthening of a synaptic connection for an extended period of time, usually due to changes in the postsynaptic receptors
169
Lower motor neurons
neurons with cell bodies in the grey matter of the spinal cord that synapse directly onto muscles, telling them to contract or relax to create movement
170
Lumbar spinal cord
the portion of the spinal cord that carries information to and from (innervates) the hips and fronts of the legs
171
Magnetic resonance imaging (MRI)
a medical imaging technique that uses a magnetic field and computer- generated radio waves to create detailed images of the organs and tissues in the body
172
Mechanoreceptor
a type of somatosensory receptor that transduces touch information through mechanically gated ion channels
173
Medial geniculate nucleus
the region or nucleus of the thalamus used to relay auditory information to the cerebral cortex
174
Medulla
the bottommost part of the brainstem where the brain and spinal cord connect; a key conduit for nerve signals to and from the body, controlling vital processes like the heartbeat, breathing, and blood pressure
175
Meissner's corpuscle
a type of somatosensory mechanoreceptor used to transduce light fluttering vibration from glabrous skin
176
Membrane potential
the difference in charge (electric potential) across a cell membrane; represented by the symbol Vm
177
Memory consolidation
the process by which recently learned experiences are transformed into long-term memory
178
Meninges
three layers of membranes that protect the brain and spinal cord; they include the pia mater, arachnoid, and dura mater.
179
Merkel's disc
a type of somatosensory mechanoreceptor used to transduce light touch information from regions where the sense of touch is highly acute
180
Metabotropic receptor
a type of membrane receptor that initiates a series of intracellular events to modulate cell activity; often indirectly linked with ion channels through complex signaling mechanisms
181
Microglia
immune cells of the central nervous system that primarily function to clear dead neurons and pathogens
182
Microtubules
microscopic tubular structures that form part of the cytoskeleton and are key structural/ functional elements in axons; provide structure/ shape to eukaryotic cells and are involved in several functions, including cell division and movement
183
Midbrain
the topmost part of the brainstem that plays a key role in processing and integrating visual and auditory signals
184
Middle ear
transfers and magnifies sound waves from the ear canal and ear drum to the inner ear, where the sound waves are transduced
185
Millivolt
a unit used to measure the difference in electrical charge across a membrane (membrane potential)
186
Mitochondria
membrane-bound cell organelles that generate most of the chemical energy needed to power the cell's biochemical reactions; commonly referred to as the powerhouse of the cell
187
Modulatory
having the effect of regulating or adjusting
188
Monocular
having input from one eye
189
Monocular deprivation
an experimental manipulation that deprives one eye of normal vision in order to study changes in development
190
Morphology
a neuron's particular shape
191
Mossy fibers
"axons sent by small neurons in the dentate gyrus to the main part of the hippocampus called Ammon's Horn; note that there is also a set of axons found in the cerebellum called ""mossy fibers."""
192
Muscle spindle
stretch receptors buried in skeletal muscle that detect the length of a muscle and report this to the brain for proprioception, or body position perception
193
Myelin
an insulating layer made up of protein and fatty substances that forms around nerves (axons); allows electrical impulses to transmit quickly and efficiently along the axons
194
Myofibrils
the long fibers of protein filaments that make up a muscle, which can contract to shorten or relax to lengthen
195
Myopia
the inability to see objects far away clearly (nearsightedness)
196
Myotatic reflex
also known as the knee jerk reflex, in which the muscle of the front thigh contracts in response to the stretching of the tendon attaching the muscle to the knee
197
N170
a peak in electrical activity that reflects the neural processing of faces and sometimes familiar objects; N170 changes in size or amplitude based on the type of face shown.
198
Nernst equation
a mathematical relationship used to calculate the membrane potential at which the electrical and concentration gradients for a given ion balance out (ionic equilibrium potential)
199
Neural network
a method of artificial intelligence that teaches computers to process data in a way that is inspired by the human brain
200
Neurogenesis
the process by which new neurons are formed in the brain
201
Neuromuscular junction
a synaptic connection between the terminal end of a motor nerve and a muscle; the site for the transmission of an action potential from the nerve to the muscle
202
Neuron
the information-processing cell of the nervous system; also called a nerve cell; most neurons use action potentials to send signals over a distance, and all neurons communicate with one another using synaptic transmission.
203
Neuronal membrane
the membrane of a neuron that separates the interior of the cell from the outside environment
204
Neurotransmitter
chemical messengers that carry information from one neuron to the next target cell; neurotransmitters are usually produced in the soma and shipped down the axon to the terminal, where they are released via exocytosis and can diffuse to the next cell.
205
NMDA receptor (N-methyl-D-aspartate receptor)
type of ionotropic receptor of glutamate, the primary excitatory neurotransmitter in the human brain; the binding of glutamate is typically not sufficient to open the channel, as it may be blocked by Mg2+ ions, which are removed when the neuron is sufficiently depolarized
206
Nociception
the sensation or perception of pain
207
Nodes of Ranvier
gaps in the myelin sheath along a neuron where an axon comes in contact with the extracellular fluid; facilitate the rapid conduction of nerve impulses and prevent degradation of the action potential as it travels down the axon
208
Noncompetitive agonist
a substance that can enhance the activity of a neurotransmitter without blocking its binding site by binding to a different site (allosteric site)
209
Noncompetitive antagonist
a molecule that does not compete for the same binding site as the natural (endogenous) neurotransmitter, binding to an allosteric site; it has the opposite effect as the natural neurotransmitter.
210
Noninvasive
refers to a medical procedure that does not require the introduction of instruments or foreign substances into the body
211
Norepinephrine
"type of catecholamine (derived from the molecule tyrosine) neurotransmitter; also known as noradrenaline; plays a key role in mediating the ""fight or flight"" response"
212
Nucleus (pl. nuclei)
a membrane-enclosed organelle within a cell that serves both as the repository of genetic information and as the cell's control center
213
Occipital lobe
one of the four major lobes of the cerebral cortex; sits at the back of the head and is responsible for visual processing
214
Ocular dominance columns
stripes of neurons in the visual cortex that respond preferentially to input from one eye over the other
215
Odorants
chemical particles in the air that can be transduced by olfactory receptor neurons
216
Olfactory bulb
an extension of the brain that is found below the frontal lobe, which contains several types of nerve cells that are involved in the sense of smell
217
Olfactory epithelium
the specialized tissue found in the nasal cavity or sinuses in which olfactory receptor neurons are found
218
Oligodendrocytes
glial cells that provide myelin in the central nervous system
219
Opsin
a light-absorbing pigment; each absorbs a different wavelength or color of light; each type (color) of cone has its own type of opsin, which preferentially absorbs and transduces that one wavelength of light.
220
Optic chiasm
the place in the brain that forms an X-shaped structure where some of the optic nerve fibers coming from one eye cross optic nerve fibers from the other eye
221
Optic nerve
a bundle of axons that carry visual messages; formed by the axons of retinal ganglion cells leaving the eye
222
Optic tract
a bundle of axons that carry visual information from the optic chiasm to the brain, as a continuation of the optic nerve
223
Optogenetics
a method of controlling a neuron's activity using light and genetic engineering
224
Organ of Corti
the structure in the cochlea of the inner ear in which the hair cells are found
225
Ossicles
the small bones found in the middle ear that act like a series of levers to transfer and magnify the sound waves from the ear drum to the cochlea of the inner ear
226
Outer hair cells
cells of the inner ear featuring stereocilia, or long hair-like appendages, that can extend or contract to magnify the vibration of the basilar membrane, which helps the cochlea transduce with high sensitivity and accuracy
227
Overshoot
the peak of the action potential when the membrane potential is more positive than 0 mV
228
Pacinian corpuscle
a type of somatosensory mechanoreceptor used to transduce deep vibration information
229
Parallel processing
the ability of the brain to simultaneously process incoming stimuli, including color, motion, shape, and depth, separately by different cells at all levels of the visual system
230
Parasympathetic nervous system
"a division of the autonomic nervous system involved in ""rest and digest""; maintains the heart rate and respiratory, metabolic, and digestive functions"
231
Parietal lobe
one of the four major lobes of the cerebral cortex; located at the upper back area in the skull; processes sensory information received from the outside world like touch, taste, and temperature
232
Partial agonist
a substance that competes for the same binding site as an endogenous neurotransmitter but has a smaller effect on the postsynaptic receptor
233
Passive transport
a type of membrane transport that does not require energy to move substances across cell membranes
234
Paul Broca
"a French surgeon and scientist known for his work supporting the localization of speech and language to the left side of the brain; this region is known as ""Broca's Area."""
235
Perforant path
an axon bundle extending from the entorhinal cortex to a region of the hippocampus called the dentate gyrus
236
Peripheral nervous system (PNS)
the part of the nervous system that lies outside the brain and spinal cord; plays a key role in sending information from different areas of the body back to the brain; involved in voluntary movements and regulating involuntary (autonomic) functions, such as heart rate and digestion
237
Permeable
allows substances to pass through
238
Perturb
to alter the function of a biological system
239
Phantom limb syndrome
a condition in which patients experience sensations in a limb that does not exist due to the connections from the periphery to the brain remaining in place after amputation
240
Phosphorylation
the process in which a phosphate group is added to a molecule, often serving to increase its activity
241
Photoreceptors
cells in the eye's retina that are responsible for converting light into signals that are sent to the brain
242
Phrenology
a pseudoscience involving the measurement of bumps on the skull to predict mental traits and abilities; now known to be without scientific merit
243
Pia mater
the thin, innermost layer of the three protective membranes (meninges) that cover the brain and spinal cord; keeps the cerebrospinal fluid outside the brain but allows blood vessels to pass through to access the brain
244
Pigmented epithelium
a pigmented cell layer just outside the neurosensory retina that works to support the function of photoreceptors in a variety of ways, including absorbing excess light
245
Pinnae
the visible, external part of the ear that resides on the outside of the head
246
Pituitary gland
"referred to as the ""master gland"" because it monitors and regulates many bodily functions through the hormones that it produces; acts as a control center for most other endocrine glands in the body"
247
PLC (phospholipase C)
a class of membrane-bound enzymes that cleave or break apart phospholipids; specifically, PLC cleaves the membrane phospholipid phosphatidylinositol 4-5-bisphosphate to form the second messengers DAG and IP3.
248
Pons
the middle portion of the brainstem that serves as a bridge between the medulla and the thalamus; involved in coordinating facial movements, chewing muscles, hearing, and balance
249
Population coding
a method of representing stimuli by using the coordinated activities of a number of neurons working together
250
Postsynaptic density
an area of the postsynaptic membrane by the synaptic cleft that is thickly clustered with receptors and their attached molecular machinery
251
Postsynaptic neuron
the neuron receiving a signal on the other side of the synaptic cleft (the space between neurons at a synapse)
252
Potassium leak channel
the channel responsible in part for the negative resting potential of most neurons; these channels are always open, causing the cell to leak positively charged potassium ions.
253
Prefrontal cortex
the cerebral cortex covering the front part of the frontal lobe; plays a central role in functions such as thinking, feeling, and cognition
254
Premotor cortex
an area of the cerebral cortex found in the back of the frontal lobe where motor commands are planned out before they are executed
255
Presynaptic neuron
the neuron releasing the neurotransmitter signal at the synapse (the point where two neurons communicate)
256
Primary auditory cortex
an area of the cerebral cortex found in the upper gyrus of the temporal lobe that is responsible for integrating and processing auditory perception
257
Primary gustatory cortex
an area of the cerebral cortex found in the insula that is responsible for flavor and taste perception
258
Primary motor cortex
an area of the cerebral cortex found at the very back of the frontal lobe that is responsible for issuing motor commands to the muscles of the body
259
Primary somatosensory cortex
an area of the cerebral cortex found at the front of the parietal lobe (next to the motor cortex) that is responsible for integrating and processing touch, pain, and temperature signals from the body
260
Primary visual cortex (V1)
the region of the cortex found at the very back of the brain that is specialized for the initial processing of visual input
261
Priming
a phenomenon in which exposure to one stimulus influences how a person responds to a subsequent, related stimulus
262
Procedural memory
a type of long-term memory involved in the performance of different actions and highly practiced skills; essentially, it is the unconscious muscle memory of how to do certain things, like how to ride a bike.
263
Propagate
to move a signal (action potential) down the axon of a neuron
264
Proprioception
the sense of where your body is in space; calculated by the stretch and force on your muscles, joints, and tendons
265
Prosopagnosia
a neurological disorder characterized by the inability to recognize faces
266
Pupil
the opening that allows light to enter the eye
267
Pyramidal cells
neurons characterized by a pyramidal- shaped cell body (soma) and two distinct dendritic trees; these are the most prevalent neuronal type in the cerebral cortex.
268
Radio frequency (RF) pulse
the pulse used in MRIs that is applied for a few milliseconds to disturb the alignment of atoms from the main magnetic field
269
Receptive field
a specific region in the sensory domain (for vision, a region of visual space; for touch, a region of the skin, etc.) where an appropriate stimulus can evoke a neuronal response
270
Reflex
an involuntary movement in response to a stimulus; does not receive or require conscious thought
271
Refraction
the bending of light rays that can occur when the rays travel from one medium to another
272
Relative refractory period
the interval of time during which a second action potential can be initiated, but initiation will require a greater stimulus than was previously required to reach threshold
273
Resting membrane potential
the membrane potential maintained by a cell when it is not generating an action potential; many neurons have a resting membrane potential of about -65 mV.
274
Reticulospinal tract
one of the descending motor pathways bringing motor information down from the brain to the muscles (specifically, for gross movement and posture of the trunk)
275
Retina
the thin layer at the back of the eyeball containing cells that are sensitive to light and send nerve impulses along the optic nerve to the visual cortex
276
Retinal ganglion cells
neurons that connect the input from the retina to the visual processing centers within the brain
277
Retinofugal pathway
connects the retina to the primary visual cortex (V1) through the lateral geniculate nucleus (LGN)
278
Retinotopic map −
a map of visual information from the retina onto neurons in the visual cortex
279
Reuptake
the movement of neurotransmitter in the synaptic cleft back into the presynaptic cell to be repackaged and recycled
280
Rhodopsin
light-sensitive photopigment in rods
281
Rising phase
the first part of an action potential; characterized by a rapid depolarization of the membrane as positive sodium ions rush into the cell
282
Rod
photoreceptor in the retina specialized for low-light vision; more numerous in the periphery of the retina
283
Rubrospinal tract
one of the descending motor pathways bringing motor information down from the brain to the muscles (specifically, voluntary movement relating to maintaining muscle tone)
284
Ruffini's corpuscle
a type of somatosensory mechanoreceptor used to transduce stretch sensation information
285
Sacral spinal cord
the portion of the spinal cord that carries information to and from (innervates) the buttocks, backs of the legs, and the genitalia
286
Saltatory conduction
the conduction of an electrical impulse in a manner such that it skips from node to node down the full length of a myelinated axon
287
Schaffer collaterals
axons of the neurons in the CA3 regions of the hippocampus that form synapses in the CA1 regions, transferring information from the CA3 to the CA1 region; play an integral part in memory formation
288
Schwann cells
glial cells that play essential roles in insulating (myelinating) and supplying nutrients to neuronal axons in the peripheral nervous system
289
Second messenger
a short-lived chemical signal in the cytosol that can trigger a response; second messenger formation is usually stimulated by a first messenger (a neurotransmitter or hormone) binding to a G-protein coupled receptor.
290
Semantic memory
a type of long-term memory involving the recollection of words, concepts, or numbers
291
Semicircular canals
three tiny, fluid-filled tubes in the inner ear that transduce information about spin and rotation of the head in order to help maintain balance
292
Sensitization
a learning process in which the repeated administration of a stimulus results in the progressive amplification/strengthening of a behavioral response
293
Sensory homunculus
a topographical representation of the body found in the cerebral cortex, mapping out which sensory signals come from which parts of the body
294
Sensory receptor
a receptor that detects and transduces sensory stimuli like light, sound, and pressure into electrochemical signals that the nervous system and brain can receive, process, and understand
295
Sensory transduction
the process of translating sensory stimuli such as light, sound, or pressure on the skin into electrochemical signals via a sensory receptor
296
Serotonin
a neurotransmitter, also known as 5-hydroxytryptamine, that is notable for its function in mood and emotion
297
Short-term memory
the capacity to store a small amount of information in the mind and keep it in an active, readily available state for a short time
298
Signal amplification
the process in which the strength of a signal is increased after the binding of one signal molecule to a receptor; this binding triggers a chain of events that not only carries the signal to the cell interior, but also amplifies it.
299
Signal cascades
a series of chemical reactions that occur within a biological cell when initiated by a stimulus
300
SNARE proteins
proteins that mediate the fusion of vesicles with their target membrane; play a notable role in mediating neurotransmitter release from synaptic vesicles in neurons (exocytosis)

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