1A patient who suffered carbon monoxide poisoning. The damage to her brain made it so that she could no longer identify faces and objects, but was still aware of their location and how to interact with them (eg. pick them up).
D. F.
2The process of translating environmental stimuli into signals the brain can understand.
Transduction
3Visible waves with longer wavelengths look more _____, while visible waves with shorter wavelengths look more _____.
Red, blue/purple
4The amplitude of a wave.
Intensity
5A phenomena where light bends when it goes through a different medium (the cornea takes advantage of this to focus).
Refraction
6Contraction of ciliary muscles controlling the lens in the eye causes nearer images to come into focus on the retina.
Accommodation
7This is the most common type of visual impairment in young people, where they struggle to see things that are far away because their eyeballs are too long. There is evidence pointing to indoor lighting as the cause for this.
Myopia
8Farsightedness, where people struggle to see things up close due to short eyeballs.
Hyperopia
9Age-related farsightedness, that occurs as the lens loses flexibility with age.
Presbyopia
10The transparent outer layer of the eye, does most of the work to focus.
Cornea
11The colored part of the eye, a muscle that restricts the amount of light entering the eye.
Iris
12Part of eye that lets light in.
Pupil
13This part of the eye is controlled by ciliary muscles, it changes shape to fine-tune the image on the retina.
Lens
14These muscles control the lens, they contract to bring nearer items into focus.
Ciliary muscles
15A layer of neurons in the back of the eye that turns light into neural signals.
Retina
16Sensory neurons that detect light and turn it into neural signals.
Photoreceptors
17How are humans able to see in such a vast range of light levels?
Each photoreceptor constantly changes its sensitivity to match the average level of ambient illumination, and within that it has a range of about 100-fold (light 1/10th the average intensity will completely depolarize it, light 10 times the average will completely hyperpolarize it).
18A steady inward flow of positive ions into bipolar and ganglion cells makes it so that in the darkness they are constantly depolarized and releasing glutamate, what is the term to describe this phenomenon?
Dark current
19Light-sensitive pigment used by rods.
Rhodopsin
20There are about 100 million of these photoreceptors in the eye, they provide us with scotopic vision, they are sensitive to light and operate at many light levels but insensitive to color.
Rods
21There are about 4 million of these photoreceptors in the eye, they provide us with photopic vision, they don't work at low light levels but have high acuity and can see color.
Cones
22What is it called when information from multiple cells converges to one cell?
Convergence
23These cells can be on or off-center, they communicate between the photoreceptors and the retinal ganglion cells.
Bipolar cells
24These cells form the optic nerve and send action potentials from the eye to the brain.
Retinal ganglion cells
25These cells aid in lateral communication between photoreceptors and bipolar cells. ____ cells are between the photoreceptors and bipolar cells, and ____ cells are between the bipolar and retinal ganglion cells.
Horizontal, amacrine
26How is the projection of the visual field on the retina different from what you actually see/what is actually there?
It is upside down and backwards
27What is the purpose of having on-center and off-center cells?
It highlights differences in brightness, increases contrast and visual acuity.
28The middle of the visual field.
Fovea
29Made up of the axons of the ganglion cells, this brings visual information from the eyes to the optic chiasm in the brain.
Optic nerve
30This is a blind spot in the eyes due to it being the location of many retinal ganglion cells going toward the brain.
Optic disk
31This is where the optic nerves from both eyes cross.
Optic chiasm
32This is a continuation of the optic nerve after it crosses the optic chiasm, it brings the signals to the lateral geniculate nucleus.
Optic tract
33The area in the thalamus where visual signals are sent
Lateral geniculate nucleus
34When the activity of a bipolar cell inhibits other bipolar cells (via horizontal cells)
Lateral inhibition
35What is an effect of lateral inhibition on our vision?
Contrast enhancement
36Which optical illusion involves looking at different colored bands, which appear darker on the side next to a lighter band and lighter on the side next to a darker band?
Mach bands
37Which optical illusion involves a grid that appears to have gray dots on it, but they vanish when you look directly at them?
Hermann grid illusion
38How is visual information sent to the brain (in terms of left and right)?
Information from the left visual field goes to the right hemisphere, vice versa
39Nerves leading from the LGN to the primary visual cortex.
Optic radiations
40What is the projection of the retina in the brain like?
It is topographic, meaning it is like a 2D map of the visual field, which is upside down and backward compared to what we see.
41Another name for the primary visual cortex
Striate cortex
42What are visual areas outside the striate cortex called?
Extrastriate cortex
43These cortical cells respond best to an edge or a bar with a particular width, location, or orientation.
Simple cortical cells
44These cortical cells require movement (often in a specific direction) to respond actively.
Complex cortical cells
45What does the ventral visual stream detect?
What an object is
46What does the dorsal visual stream detect?
Where an object is in space
47Where in the brain do we perceive visual motion?
Area V5
48What kind of color mixing do we get from light?
Additive color mixing
49What theory is described: the brain has blue-sensitive, red-sensitive, and green-sensitive receptors, each with a separate path to the brain, colors recognized are based on which receptors were activated.
Trichromatic theory
50What theory is described: there are 4 unique hues (blue, green, red, yellow) and 3 opposed pairs of colors (blue and yellow, green and red, black and white) as the basis of color vision.
Opponent process theory
51A condition including misalignment of 2 eyes where one eye has poor acuity.
Amblyopia
52A perceptual blind spot caused by injury, this can be used to diagnose damage to parts of visual areas.
Scotoma
53A phenomenon where one has some visual discrimination and ability to correctly perceive objects in a blind spot/somewhere they can't see.
Blindsight
54A condition where one's dorsal "where" stream is damaged/destroyed so they can identify objects but can't perceive where they are in space.
Optic ataxia
55The leading cause of age-related vision loss due to retinal damage.
Macular degeneration
56What causes colorblindness (dichromatic vision)?
The genes for the L and M cones are both on the X chromosome, 1 of these genes can be defective (most commonly M cone), since men only have one X chromosome they are more likely to be colorblind (8% of men compared to 0.5% of women).
57What are the benefits of binocular vision?
Depth perception and more accurate spatial judgements.
58How have humans managed to give color vision to squirrel monkeys?
By giving them genes for a third photopigment.
59What are pure hues (of blue, green, yellow, red) called?
Unique hues
60What is frequency of a soundwave perceived as?
Pitch
61What is intensity/amplitude of a soundwave perceived as?
Loudness
62The combination of component frequencies that make up all natural sounds.
Complexity
63What is complexity of a soundwave perceived as?
Timbre
64Frequency is measured in ___ while intensity is measured in ___.
Hertz, decibels
65A sound with only 1 frequency of vibration.
Pure tone
66The lowest frequency in a sound, all other frequcies are multiples of this frequency.
Fundamental frequency
67Multiples of the fundamental frequency.
Harmonics
68What are the structures of the outer ear?
The pinna and the ear canal.
69What are the structures of the middle ear?
The tympanic membrane, ossicles, oval window, round window.
70What are the structures of the inner ear?
The cochlea, semicircular canals, auditory nerve.
71The visible outer part of the ear, this funnels sounds into the ear canal and has ridges and valleys that enhance and suppress different frequencies.
Pinna
72This structure gets hit with soundwaves from the ear canal and vibrates with the same frequency as them to pass soundwaves on to the middle ear.
Tympanic membrane/eardrum
73These tiny bones vibrate from soundwaves, they concentrate and amplify the vibration so it can be transferred to the inner ear, which contains a denser medium than air.
Ossicles
74What are the 3 ossicles?
Malleus, Incus, Stapes
75A specialized patch of membrane that transfers vibrations from the ossicles to the inner ear.
Oval window
76A specialized patch of membrane that releases pressure out from the cochlea.
Round window
77A coiled, fluid-filled part of the inner ear that contains the hair cells that transform vibrational waves into neural signals.
Cochlea
78A receptor system inside the scala media of the cochlea, it contains hair cells, which convert vibrations to neural signals.
Organ of Corti
79One of the cochlea's fluid-filled chambers, this runs from the apex of the cochlea to the round window to help transmit pressure waves that cause the basilar membrane to vibrate.
Scala tympani
80One of the cochlea's fluid-filled chambers, this runs from the oval window to the apex of the cochlea. The ossicles cause the fluid in this chamber to vibrate, causing vibration in the basilar membrane.
Scala vestibuli
81One of the cochlea's fluid-filled chambers, this contains the Organ of Corti.
Scala media
82When the fluid in the scala vestibuli ripples, it causes ripples/vibrations in this structure, which causes hair cells on it to send action potentials, converting the sound waves to neural signals and encoding them based on frequency. Lower frequency sounds are encoded near the apex of this structure, while higher frequency sounds are encoded near the base.
Basilar membrane
83What theory states that pitch is determined by the location of activated hair cells on the basilar membrane?
Place coding theory
84What theory states that the frequency of a sound is encoded in the rate of firing of hair cells, often with multiple cells working together through phase-locking/the volley principle?
Temporal coding theory
85When nerve fibers fire in bursts at or near the peak of a sine wave stimulus, in phase with the wave.
Phase-locking
86What is tonotopic organization in the auditory system?
All neurons in the auditory system are organized by frequency.
87Human cochleas have one row of these cells, they provide the brain with signals about sounds.
Inner hair cells
88These cells in the cochlea convey information to the brain about the mechanical state of the basilar membrane and allow the brain to continually modify the stiffness of parts of the basilar membrane.
Outer hair cells
89A sloping brush of tiny hairs on hair cells, these form a bridge from the hair cell and basilar membrane to the tectorial membrane. When the basilar membrane ripples, these hairs bend, opening an ion channel that lets K+ and Ca2+ into the hair cell and depolarizing it.
Stereocilia
90These connect the tips of adjacent stereocilia. When stereocilia bend, pressure is put on these, leading to the opening of ion channels.
Tip links
91A gel-like structure above the organ of Corti, this has stereocilia embedded in it.
Tectorial membrane
92This type of fiber in the vestibulocochlear nerve makes up about 95% of the fibers in it, it conveys action potentials from the hair cells to the brain, giving the brain perceptions of sounds.
IHC afferents
93This type of fiber in the vestibulocochlear nerve allows the brain to control the inner hair cells' responsiveness.
IHC efferents
94This type of fiber in the vestibulocochlear nerve conveys info about the mechanical state of the basilar membrane to the brain.
OHC afferents
95This type of fiber in the vestibulocochlear nerve allows the brain to continually modify the stiffness of parts of the basilar membrane, leading to sharpened tuning and pronounced amplification.
OHC efferents
96This nerve is also known as Cranial Nerve VIII, it contacts the bases of hair cells and is made up of 30,000-50,000 auditory axons from the cochlea, most of which go to the brain.
Vestibulocochlear nerve
97This dorsal pathway recognizes what a sound is, it only needs information from one ear.
Monaural pathway
98This ventral pathway uses information from both ears to localize a sound.
Binaural pathway
99This binaural cue can help localize a sound by comparing the intensity of the sound in both ears.
Interaural intensity differences
100This binaural cue can help localize a sound by comparing a sound's time of arrival in both ears.
Interaural temporal differences
101The difference between when both ears hear the beginning of the sound.
Onset disparity
102A continuing mismatch in a sound's time of arrival (after the beginning of the sound).
Ongoing phase disparity
103This part of the brain measures the interaural temporal differences to help localize sounds.
Medial superior olives
104This part of the brain measures interaural intensity differences to help localize sounds.
Lateral superior olives
105Sound with frequencies below 20 Hz
Infrasound
106Sound with frequencies above 20,000 Hz
Ultrasound
107The hills and valleys of our ears amplify/diminish some frequencies depending on the angle at which sound strikes the external ear or the elevation of sound.
Spectral filtering
108This brain region integrates binaural and spectral cues for sound localization.
Inferior colliculi
109After going to the inferior colliculi, sound information goes to this part of the thalamus, where it will later go to several auditory cortical areas.
Medial geniculate nuclei
110A type of hearing loss where the ear fails to convert sound vibrations into waves of fluid in the cochlea. A common cause of this is the ossicles fusing together.
Conduction deafness
111A type of hearing loss where the organ of Corti and the hair cells fail to convert ripples in the basilar membrane into action potentials. This can be genetic, or caused by drugs or infections, but is often caused by permanent damage to hair cells after listening to too many loud noises.
Sensorineural deafness
112A constant ringing in the ears, often caused by listening to too many loud noises.
Tinnitus
113A type of hearing loss where auditory brain regions are damaged and can't process action potentials, often due to strokes, tumors, or traumatic injuries.
Central hearing loss/deafness
114A lifelong inability to discern tunes or sing due to subtly abnormal connectivity between the primary auditory cortex and regions of the right frontal lobe for pitch discrimination.
Amusia
115A solution to sensorineural deafness where a device sends data about sounds directly to nerve fibers in the cochlea.
Cochlear implants
116A phenomenon used by bats and somewhat humans where sound waves can be used to tell us if an object is coming toward us or away from us.
Echolocation
117An auditory illusion that creates the impression of a constantly ascending pitch.
Shepard scale
118How does a missing fundamental affect the pitch/timbre of a sound?
The perceived pitch stays the same, but the timbre changes.
119The structures that adjourn the cochlea and help us with hearing and balance.
Vestibular system
120The 3 canals of the vestibular system, each in a different dimension (pitch, yaw, roll).
Semicircular canals
121How do taste receptor cells on the papillae work?
Each cell is sensitive to 1 taste, salty and sour are perceived through the opening of ion channels while sweet, bitter, and umami are perceived by specialized receptor molecules.
122These can be found on the walls of the papillae, each containing 50-150 taste receptor cells.
Taste buds
123The bumps on one's tongue.
Papillae
124Action potentials for each sense are carried through separate dedicated nerves, so the brain recognizes the signals from each sense as distinct. What is the term for this?
Labeled lines
125These touch receptors only respond to vibrations of over 200 cycles per second, they detect vibrations and pressure and are phasic.
Pacinian corpuscles
126These touch receptors help us perceive the form of an object by responding to changes in stimuli and can detect localized movements between the skin and a surface (grip control). They are phasic.
Meissner's corpuscles
127These touch receptors help us perceive forms of objects, they are responsive to edges and isolated points on a surface. They are tonic.
Merkel's discs
128These touch receptors detect stretching of patches of skin during movement. They are tonic.
Ruffini corpuscles
129These touch receptors detect pain, itch, and temperature stimuli. They are tonic.
Free nerve endings
130These receptors detect changes in temperature on the surface of the skin relative to body temperature.
Thermoreceptors
131A progressive decrease in a receptor's response to sustained information.
Sensory adaptation
132Receptors that use sensory adaptation.
Phasic receptors
133Receptors that don't use sensory adaptation.
Tonic receptors
134How touch signals are sent up the spinal cord: the axon goes up to the medulla, synapses at the medulla, and is then sent to the contralateral side of the body (starting at the thalamus, then the somatosensory cortex).
Dorsal column
135How pain signals are sent up the spinal cord: the axon synapses in the dorsal part of the spinal cord, then the info is sent to the contralateral side before the axon goes to the thalamus.
Anterolateral column
136The ability to distinguish two nearby touch points on the skin as separate stimuli rather than one. This is tested on different parts of the body and typically the strongest in sensitive parts like the lips, fingers, etc.
Two-point discrimination
137A discrete band of skin innervated by a particular spinal dorsal root.
Dermatome
138Why do we have quick reflexes to painful stimuli (eg touching a hot stove)?
This is because these signals are picked up by TRPM3 receptors, which have thick myelinated axons that quickly get signals to the spinal cord.
139A technique to measure the electrical activity of muscles.
Electromyography
140Pain receptors, free nerve endings specialized to detect damage.
Nociceptors
141What brain regions do pain signals initially get sent to?
Periaqueductal gray, cingulate cortex
142How does the somatosensory cortex help us process pain?
Helps us localize it
143How does the prefrontal cortex help us process pain?
Helps us put attention on/away from it
144How does the insula help us process pain?
Helps us know what degree of pain we are feeling, or empathize with others' pain.
145How does the amygdala help us process pain?
It can alter the degree of pain we feel.
146What are the differences between A delta fibers and C fibers?
A delta fibers are thick and myelinated, they project action potentials quickly (used for quick pain leading to reflexes). C fibers are thin and unmyelinated, they project action potentials slowly (good for slower, aching pain).
147When people with amputated limbs experience pain in the area where the limb was.
Phantom limb pain
148A cure to phantom limb pain, this tricks patients into thinking they have control of the missing limb using mirrors.
Mirror therapy
149When you still feel pain after an injury has healed, this is a maladaptive form of neuroplasticity where neurons continue to signal pain when it is no longer helpful.
Neuropathic pain
150A theory about pain that gates in the spinal cord are what allow the pain signal to be perceived, closing these gates can provide pain relief.
Gate control theory
151Greek word for pain relief
Analgesia
152A pain management strategy where one believes they will receive pain medication, in some people this causes the release of endorphins (endogenous opioids), which provide pain relief.
Placebo
153This pain management strategy alters the brain's perception of the pain.
Hypnosis
154This is a factor that can cause both the release of endogenous opioids and another system (likely endocannabinoids) to cause pain relief.
Stress
155This type of drug can cause pain relief by binding to opioid receptors in the periaqueductal gray and spinal cord.
Opioids
156This drug can block pain signals in the spinal cord.
Spinal block
157These drugs can block chemical inflammatory signals at the site of injury.
Anti-inflammatory drugs
158This drug acts in nociceptor endings, the spinal cord, and brain to block pain signals.
Cannabinoids
159Mild electrical stimulation applied around an injury site, it can block or alter pain signals by releasing endogenous opioids.
Transcutaneous electrical nerve stimulation (TENS)
160A needle-based method of pain relief with placebo-like effects.
Acupuncture
161Pain inhibition that starts in the periaqueductal gray, it electrically activates endogenous opioids.
Central gray
162What did UW researchers find about VR games and pain management?
VR provides good pain management compared to other video games.
163What is the condition where one can't feel pain?
Congenital insensitivity to pain
164The body's ability to sense what is happening inside the body.
Interoception
165What are the five tastants?
Salty, sour, sweet, bitter, umami
166When mice were genetically modified so their bitter (T2R) taste receptors were expressed in cells that normally detect sweet tastes, then given a bitter tasting compound, what happened?
The mice acted as if the compound tasted sweet, showing that how something tastes is determined by the type of receptor cell, not the specific receptor protein.
167When the brain tracks a specific stimulus through the behavior patterns of many neurons.
Pattern coding
168The basic detection of chemical stimuli while tasting (1 of the 5 tastes)
Taste sensation
169The interpretation of taste, smell, temperature, texture, etc to create flavor.
Taste perception
170People whose tongues have more papillae than average. These people are more sensitive to sweet and bitter tastes.
Supertasters
171These neurons pick up smell signals, they can regenerate even in adulthood. They have one dendrite with branches (cilia) containing olfactory receptor proteins, a thin unmyelinated axon, and synapse in the olfactory bulb.
Olfactory neurons
172This part of the brain gets signals about smell, contains glomeruli, and sends signals to parts of the brain such as the hippocampus, amygdala, and prepyriform cortex.
Olfactory bulb
173A part of the nasal cavities which is lined with a sheet of cells.
Olfactory epithelium
174A bony part separating the nasal cavities from the brain, it has small holes to the axons of olfactory neurons can pass through.
Cribriform plate
175Also known as the primary olfactory cortex, this is where smells are identified.
Prepyriform cortex
176A spherical clump of neurons in the olfactory bulb, this receives inputs from an olfactory neuron with the same receptor protein, after getting a signal it sharpens neural activity associated with corresponding odorants. These are organized topographically.
Glomerulus
177How do we localize smells (via 2 nostrils)?
Similar to interaural differences in hearing, we do this using intensity and temporal differences.
179This organ can detect pheremones, though it is either old and insignificant or absent in humans.
Vomeronasal organ (VNO)
180A chemical signal released by one individual that affects the behavior or physiology of another member of the same species.
Pheremone