1What is the scientific name of the Mouse
Mus Musculus
2What are 5 uses for laboratory mice?
1. Acute Toxicity Studies
2. Assay of Insulin
3. Screening of chemotheraputic and teratogenic agents
4. Cancer and genetic research
5. Isolated preparation - Vas deferens, ileum
3What is the hairless genetic mutant variant of mice?
Nude Mouse
4What are the 4 blood collection techniques requiring anesthesia for mice?
Tail vein, Tail snip, orbital sinus, Jugular vein
5What are the 2 blood collection techniques not requiring anesthesia for mice?
Saphenous vein, Dorsal pedal vein
6마우스의 성성숙은 암/수 각각 며칠인가?
수컷: 45~60일 (25일에 정소하강, 35일에 정자형성)
암컷: 35~50일 (절개구 25~30일)
8마우스의 평균 수명은? (암/수 구분해서 작성할 것)
암: 818일, 수: 827일
9What is the scientific name of the Rat?
Rattus norvegicus
10What are the 2 main strains of the Rat?
Wistar, Sprague dawley
11List 5 characteristics of Wistar rats.
1. Resistant to infections
2. Low incidence of tumours
3. Wide head
4. Long ears
5. Tail length < body length
12List 4 characteristics of Sprague-Dawley rats.
1. Rapidly growing
2. Longer and narrower head
3. Longer tail
4. Less respitory infections
13What are 5 special features of the Rat?
1. Do not vomit
2. Do not have tonsil and gallbladder
3. Diffues pancreas
4. Coprophagy
5. Tail-thermoregulation
14What are 2 blood collection methods not requiring anesthesia for the rat?
Saphenous vein, Dorsal pedal vein
15What are 4 blood collection methods requiring anesthesia for the rat?
Tail vein, Orbital sinus, Jugular vein, Blood vessle cannulation
16What is the scientific name for the Rabbit?
Orytolagus Cuniculus
17List the 3 main strains of rabbit.
New Zealand White, American Dutch, Californian
18What is the weight of the NZW, AD, and C rabbit respectively?
5kg, 2kg, 4.5kg
19What is the Biological Data of a rabbit? (Typical adult weight, average life span, gestation period, average litter size)
1500~5000g, 4~6yrs, 31 days, 6~8
20What are some special features of the Rabbit?
It has huge caecum and long appendix, Enzyme atropine esterase is present, very sensitive to histamine, ovulation is non-spontaneous
21What is the Draize test, and how does it work on the Rabbit?
Testing for cosmetics and other chemicals, Substance -> Rabbit's eyes or skin -> Redness, irritation or any damage
22What is the scientific name of the Guinea Pig?
Cavia Porcellus
23What is the Biological Data of a guinea pig? (Typical adult weight, average life span, gestation period, average litter size)
800g, 3~5yrs, 68 days, 3~4
24What are guinea pigs highly suceptible to?
TB, anaphylaxis
25What are guinea pigs highly sensitive to?
histamine, penicilin
26What is the maximum blood collection volume for mice, rats, rabbits, and guinea pigs repectively?
1mL, 10~15mL, 60~200mL, 1~25mL
27What are the 6 main uses for Pigs in laboratory experiments?
Organ transplants, diabetes, heart disease, circulation research, osteoperosis, arthritis
28순환기계연구에서 돼지를 이용하는 이유?
관상동맥의 혈액공급이 사람과 비슷, 측부순환이 사람과 유사 (심근 허혈증 연구모델)
29돼지의 외과수술, 장기이식수술, 인공장기에서 이용 사례를 서술하시오.
내시경 수술 / 간이식 / 인공간 시스템
30마우스 청정화의 정의와 과정을 적으십시오.
1. 병원성 미생물에 감염된 마우스를 SPF 마우스로 만듦
2. 수정란이식 + 자궁절제술
3. 수정란 이후 건강 모니터링을 실시하여 청정화 과정에서 미생물의 감염이 없다는 사실을 확인한다