1Phospholipids: What are the main components of biological membranes?
Hydrophilic head and hydrophobic tails
2Cell membrane function: What does the cell membrane do?
Separates intracellular and extracellular environments, anchors cytoskeleton, regulates entry/exit of substances, and facilitates cell communication
3Fluid Mosaic Model: What does the Fluid Mosaic Model describe?
The membrane as a flexible bilayer where proteins float like icebergs in a sea of lipids
4Factors influencing membrane fluidity: What factors influence membrane fluidity?
Degree of saturation, temperature, and cholesterol content
5Types of cellular junctions: What are the types of cellular junctions?
Tight junctions, anchoring junctions, and communication junctions
6Role of tight junctions: What is the role of tight junctions?
Restrict movement of substances between cells and prevent membrane proteins from migrating
7Desmosomes: What are desmosomes?
Specialized adhesive junctions that hold cells together
8Cell communication through junctions: How do cells communicate through junctions?
Gap junctions (in animals) and plasmodesmata (in plants) allow direct exchange of molecules
9Types of passive transport: What are the types of passive transport?
Diffusion, facilitated diffusion, and osmosis
10Osmosis: What is osmosis?
The movement of water across a selectively permeable membrane from low to high solute concentration
11Hypotonic solution: What happens in a hypotonic solution?
Water moves into the cell
12Hypertonic solution: What happens in a hypertonic solution?
Water moves out of the cell
13Isotonic solution: What happens in an isotonic solution?
No net movement of water
14Active transport: What is active transport?
Movement of molecules against their concentration gradient using ATP
15Sodium-potassium pump: What does the sodium-potassium pump do?
Uses ATP to move 3 Na+ out and 2 K+ into the cell
16Types of endocytosis: What are the types of endocytosis?
Phagocytosis, pinocytosis, receptor-mediated endocytosis
17Exocytosis: What is exocytosis?
Process of vesicles fusing with the plasma membrane to release materials outside the cell
18Types of cell signaling: What are the types of cell signaling?
Direct contact (Juxtacrine), Paracrine, Endocrine, and Synaptic
19Main components of cell signaling: What are the main components of cell signaling?
Ligand (signaling molecule) and receptor (molecule that binds ligand)
20Protein kinases and phosphatases: What is the difference between protein kinases and phosphatases?
Kinase adds a phosphate group; Phosphatase removes a phosphate group
21Types of receptors: What are the types of receptors?
Intracellular and cell surface/membrane receptors
22Second messengers: What are second messengers?
Small molecules (e.g., cAMP, Ca2+) that relay signals inside the cell
23Function of receptor tyrosine kinases (RTKs): What is the function of receptor tyrosine kinases?
Bind ligands, autophosphorylate, and activate intracellular signaling pathways
24Example of an RTK: Give an example of a receptor tyrosine kinase (RTK).
The insulin receptor
25MAP kinase cascade: What is the MAP kinase cascade?
A signaling pathway that amplifies signals and regulates cell functions like differentiation and apoptosis
26Cell Theory: What are the three parts of the Cell Theory?
All organisms are made of cells, Cells are the smallest living things, Cells arise only from pre-existing cells
27Cell Size Limitation: What happens as the cell size increases?
Diffusion efficiency decreases and the surface area-to-volume ratio decreases, making material exchange harder
28Basic Cell Structures: What are the basic cell structures?
Plasma membrane, cytoplasm, genetic material, and ribosomes
29Prokaryotes: What are prokaryotes?
Bacteria and Archaea
30Prokaryotic Genetic Material Location: Where is genetic material located in prokaryotes?
In the nucleoid region (not enclosed by a membrane)
31Bacterial Cell Walls: What are bacterial cell walls made of?
Peptidoglycan (Gram-positive: thick layer; Gram-negative: thin layer)
32Prokaryotic Movement: How do prokaryotes move?
Some use flagella, which rotate to propel the cell
33Unique Features of Archaea: What is unique about archaea?
They can live in extreme environments and have genes similar to both bacteria and eukaryotes
34Eukaryotic Cells: What is a feature of eukaryotic cells?
Membrane-bound nucleus and organelles, more complex structures, and a cytoskeleton
35Nucleus Function: What is the function of the nucleus?
Stores genetic material (DNA) in the form of chromatin
36Nuclear Envelope: What is the nuclear envelope?
A nuclear envelope made of two phospholipid bilayers
37Ribosome Function: What is the function of ribosomes?
Synthesize proteins
38Ribosome Location: Where are ribosomes located?
Free in the cytoplasm or attached to the rough endoplasmic reticulum (RER)
39Endomembrane System Components: What are the components of the endomembrane system?
Endoplasmic reticulum (RER & SER), Golgi apparatus, lysosomes, peroxisomes, vesicles
40Rough ER Function: What is the function of the rough ER?
Protein synthesis and processing
41Smooth ER Function: What is the function of the smooth ER?
Lipid synthesis, calcium storage, detoxification
42Golgi Apparatus Function: What is the function of the Golgi apparatus?
Modifies, packages, and distributes proteins and lipids
43Lysosome Function: What is the function of lysosomes?
Breaking down macromolecules and digesting foreign material via phagocytosis
44Vacuoles: What are vacuoles?
Membrane-bound structures for storage: Central vacuole (plants), contractile vacuole (protists), storage vacuoles
45Mitochondria Function: What is the function of mitochondria?
ATP production through oxidative metabolism
46Chloroplast Function: What is the function of chloroplasts?
Photosynthesis in plants and some protists
47Mitochondria and Chloroplasts Structures: What are the similarities between mitochondria and chloroplasts?
Both have double membranes, their own DNA, and ribosomes
48Endosymbiosis Theory: What is the endosymbiosis theory?
Eukaryotic organelles (mitochondria & chloroplasts) evolved from symbiotic prokaryotes
49Endosymbiosis Evidence: What evidence supports endosymbiosis?
Mitochondria & chloroplasts have two membranes, their own DNA & ribosomes, and bacteria-like division process
50Cytoskeleton: What is the function of the cytoskeleton?
A network of protein fibers that maintain cell shape and movement
51Types of Cytoskeleton Fibers: What are the types of cytoskeleton fibers?
Actin filaments, Microtubules, Intermediate filaments
52Prokaryotic Cytoskeleton: Do prokaryotes have a cytoskeleton?
Yes, but it is different from that of eukaryotes
53Cell Movement: How do cells move?
Crawling (actin & myosin), flagella (undulate motion), cilia (wave-like motion)
54Cilia and Flagella Structure: What is the structure of cilia and flagella?
9 + 2 structure: 9 pairs of microtubules surrounding 2 central microtubules
55Cell Wall Components: What are the components of cell walls?
Plants & protists: Cellulose; Fungi: Chitin
56Extracellular Matrix (ECM): What is the extracellular matrix (ECM)?
A structure made of glycoproteins and collagen that supports and connects cells
57ECM Communication: How does the ECM communicate with cells?
Via integrin proteins embedded in the plasma membrane
58Why is carbon important in biological molecules?
It can form up to 4 covalent bonds with other atoms, allowing complex molecules
59What are functional groups?
Specific molecular groups that give molecules distinct properties (e.g., hydroxyl, carboxyl)
60What are monomers and polymers?
Monomer: A single building block (e.g., amino acid, nucleotide); Polymer: A chain of monomers (e.g., protein, DNA)
61What is dehydration synthesis?
The process of forming polymers by removing water
62What is hydrolysis?
The process of breaking polymers by adding water
63What is the general formula for carbohydrates?
(CH2O)n
64What are the main functions of carbohydrates?
Energy storage (e.g., starch, glycogen) and structural support (e.g., cellulose, chitin)
65What are disaccharides?
Two monosaccharides linked by dehydration synthesis (e.g., sucrose, lactose, maltose)
66What are polysaccharides?
Long chains of sugars used for storage or structure (e.g., starch, glycogen, cellulose)
67What are the three types of nucleic acids?
DNA, RNA, and ATP
68What are the components of a nucleotide?
A pentose sugar, a phosphate group, and a nitrogenous base
69What are the nitrogenous bases?
Purines: Adenine (A), Guanine (G); Pyrimidines: Thymine (T), Cytosine (C), Uracil (U)
70What base is found in RNA but not in DNA?
Uracil (U) replaces Thymine (T)
71How are nucleotides linked together?
By phosphodiester bonds in a sugar-phosphate backbone
72What is ATP?
Adenosine triphosphate, the primary energy currency of the cell
73What are the functions of proteins?
Enzyme catalysis, defense, transport, support, motion, regulation, storage
74What are proteins made of?
Polymers of amino acids linked by peptide bonds
75What are the components of an amino acid?
Central carbon, amino group, carboxyl group, hydrogen, and R group
76How do R groups affect amino acids?
They determine chemical properties (e.g., nonpolar, polar, charged)
77What are the four levels of protein structure?
Primary, Secondary, Tertiary, Quaternary
78What causes protein denaturation?
Changes in pH, temperature, or salt concentration
79What makes lipids unique from other biomolecules?
They are hydrophobic (insoluble in water)
80What are the two main types of lipids?
Fats (triglycerides) and phospholipids
81What are triglycerides composed of?
1 glycerol + 3 fatty acids
82What is the difference between saturated and unsaturated fats?
Saturated: No double bonds, solid at room temp; Unsaturated: Double bonds, liquid at room temp
83Why are plant oils liquid at room temperature?
They contain unsaturated fatty acids
84What are phospholipids made of?
1 glycerol + 2 fatty acids + 1 phosphate group
85What is the structure of phospholipids?
Polar (hydrophilic) head and nonpolar (hydrophobic) tails, forming cell membranes
86Cellular organization: What does cellular organization refer to?
The structural arrangement of cells
87Ordered complexity: What does ordered complexity mean?
Living organisms have complex structures
88Sensitivity (response to stimuli): What does sensitivity refer to?
How organisms respond to environmental changes
89Growth, development, and reproduction: What does this characteristic of life involve?
The processes through which organisms grow and reproduce
90Energy utilization: What does energy utilization refer to?
How organisms use energy to maintain their functions
91Homeostasis: What is homeostasis?
The ability of an organism to maintain stable internal conditions
92Evolutionary adaptation: What does evolutionary adaptation refer to?
The changes in organisms over time to better fit their environment
93Viruses: What are viruses?
Entities that lack cellular organization and cannot reproduce independently; they require a host cell to replicate
94Primary goal of science: What is the primary goal of science?
To understand the natural world through observation, experimentation, and reasoning
95Inductive Reasoning: What is inductive reasoning?
Uses specific observations to form general conclusions
96Deductive Reasoning: What is deductive reasoning?
Applies general principles to predict specific outcomes
97Scientific method: What is the scientific method?
A systematic process involving observation, question formulation, hypothesis testing, experimentation, data collection, analysis, and conclusion
98Scientific Hypothesis: What is a scientific hypothesis?
A proposed explanation for an observation that can be tested
99Statistical Hypothesis: What is a statistical hypothesis?
A mathematical statement tested using data (e.g., null and alternative hypotheses)
100Null Hypothesis (H€ ): What is the null hypothesis?
Assumes no effect or no difference (e.g., 'PLTL leadership does not affect MCAT scores')
101Alternative Hypothesis (H• ): What is the alternative hypothesis?
Suggests an effect or a difference exists (e.g., 'PLTL leadership improves MCAT scores')
102Independent Variable (IV): What is the independent variable?
The factor being manipulated (e.g., PLTL leadership)
103Dependent Variable (DV): What is the dependent variable?
The factor being measured (e.g., MCAT score)
104Controls and constants: Why are controls and constants important in experimental design?
To ensure that only the independent variable is affecting the outcome
105Qualitative Data: What is qualitative data?
Descriptive data (e.g., color, behavior)
106Quantitative Data: What is quantitative data?
Numerical data (e.g., test scores, temperature)
107Linear regression: What is linear regression?
A statistical method that models the relationship between a dependent and independent variable
108Scientific conclusions: How are scientific conclusions determined?
By evaluating whether the null hypothesis should be rejected or not, interpreting the significance of results, and considering possible sources of error or limitations
109Hypothesis in science: What can hypotheses in science be based on?
Can only be supported or rejected based on available evidence; they cannot be proven
110Ways scientists share research findings: How do scientists share research findings?
Presentations at conferences, peer-reviewed journal articles, and academic reports