1what the body does to the drug, how the body absorbs, metabolizes, distributes, and excretes drugs
pharmacokinetics
2what the drug does to the body, effects of the drugs in the bodvvvvvyvvvvvvv
pharmacodynamics
3approximately 50% if marketed drugs are
chiral
4longer half-life; less distributed and less potentv
(R)-(+)-Warfarin
5shorter half-life; more distributed and more potent
(S)-(-)-Warfarin
6it is pharmaceutically inactivev
(R)-Ibuprofen
7same molecular formula or structure but their atoms are arranged differently
chirality
8tetratogenic which caused phocomelia
(-)(S)-thalidomide
9sedative effects and for managing morning sickness
(+)(R)-thalidomide
10two most important natural sources of alkanes
petroleum and natural gas
11complex liquid mixture of organic compounds (alkanes or cycloalkanes)
petroleum
12often found asssociated with petroleum deposits, consists mainly of methane with 80% and ethane with about 5-10%
natural gas
13major constituent of liquefied petroleum gas, a domestic fuel
propane
14gas choice in some areas
butane
15why alkanes are insoluble in water?
because water is polar and alkanes are non-polar, it is goernevd by the principle of like dissolves like
19at room temperature, alkanes occur as
gases, liquids and solids
20often constitute the parts of the protective coating on leaves and fruits
alkanes
21C27H56 and C29H50
normal alkanes
22C31H64
main alkane of tobacco leaves
23C29H50
main alkane of brocolli and cabbage
24all of the bonds in alkanes are
single, covalent and non-polar
25alkanes are relatively
inert
26alkanes ordinarily do not react with most common acids, bases or oxidizing and reducing agents
true
27alkanes can be used as solvents for extraction or crystallization as well as for carrying out chemical reactions of other substance because of its?
inertness
28alkanes do not react with some reagents such as
molecular oxygen and the halogens
29addition of O, removal of H, replacement of C-H bonds by C-O bonds
Oxidation
30one or more hydrogen atoms of the alkanes are replaced by halogen atoms
halogenation