1What are the actions of angiotensin II?
vasoconstriction
release of aldoserone
constantly vasoconstricion, reabsorping sodium and water follows sodium
2Aldosterone
retention of sodium
regulation of blood volume and blood pressure
3Renin-Angiotensin-Aldosterone System
renin - speeds the formation of angiotensin I from angiotensinogen
angiotensin-converting enzyme - located surface of all the vessels and in the lungs
42 ways RAAS acts
constricts renal blood vessels
acts on the kidney to promote retention of sodium and water and excretion of potassium
5ACE inhibitors in general work by?
work by decreasing levels of angiotensin II, can dilate vessels
adverse: increase levels of bradykinin, dilation and can cause cough -> dry cough
6ACE in general use and adverse
usually end in pril
use: hypertension, heart failure, myocardial infarction (MI)
adverse: first-dose hypotension, teratogen, cough, angioedema, hyperkalemia
7Catopril
ACE inhibitor (angiotensin-converting enzyme inhibitors)
25-50 mg/day
use: HTN
8Losartan/Cosar
angiotensin II receptor blockers
use: HTN, heart failure, MI
adverse: angioedema. teratogen, renal failure
9Aliskiren )Tekturna)
po 150 mg/day
binds tightly with renin
use: HTN
adverse: angioedema and cough, diarrhea, hyperkalemia, teratogen
10Eplerenone (Inspra)
25 mg, 50 mg PO
selective blockade of aldosterone receptors (aldosterone antagonist)
use: HTN, heart failure
adverse: hyperkalemia
drug interacts with inhibitors of CYP3A4 (P450syst)
11Spironolactone (Aldactone)
aldosterone antagonists
use: HTN, heart failure
adverse: hyperkalemia