1Cardioselective BBs
*MANBABE*
Metoprolol
Atenolol
Nebivolol-sneaky, alpha blocking too
Bisoprolol
Acebutolol-caution, has ISA
Betaxolol
2BBs with ISA
*APP* (phone APP)
(Or, A PINeapple PEN): Acebutolol, PINdolol, PENbutolol
3Lipophilic BBs (cause more CNS AEs like depression and fatigue)
Nonselectives but swap nado for nebiv, and swap timo for meto
4Hydrophilic BBs
atenolol (if you're drinking water instead of alcohol, you'd say, she's a ten? lol)
5ARBs with amlo and HCTZ for triple combo HTN drugs
OV for olmesartan and valsartan (like OVechkin scored a hat trick which is triple goals)
6CCBs that cause constipation
Cardizem and Calan Cause Constipation
7Aliskiren diarrhea
I gotta SKIRY off to the bathroom real quick
8Statins that can't be used with cyclosporine (CI)
LIpitor and LIvalo (and simva of course)
9Buy *ATT* \$30, *SCELL* For \$50
Protein inhibitors 30s ribosome
*A*=AMG (TAG, bactericidal)
*T*=Tetracyclines (blocks aminoacyl tRNA attachment; incl's doxy-, mino- & tige- cycline)
= Tigecycline (Synercid)
50s ribosome
*S*=SYNERCID
*C*=Chloramphenicol
*E*=ERY-/azi-thromycin (macrolides, binds 23s rRNA of 50s, blocks translocation)
*L*=Lincosamides (CLINDAMYCIN)
*L*=LINEZOLID (binds 23S rRNA, block initiation complex)
GO WITH BACTERICIDAL FIRST
10CYP 3A4 INDucers
*Barbie's Car Goes Real PHast*
Barbiturates
Carbamazepine
Griseofulvin
Rifampin
Phenytoin
11CHA2DS2-VASc
All 1 point unless otherwise noted
CHF
HTN
Age =>75yo (2pts)
DM
STROKE/TIA hsty (2pts)
Vascular dx
Age 65-74
Sex Category (Female)
Bactericidal antibiotics
12"Very Finely Proficient At Cell Murder".
Vancomycin
Fluoroquinolones
Penicillin
Aminoglycosides
Cephalosporins
Metronidazole
Hot as a hare
Blind as a bat
Dry as a bone
Red as a beet
13Mad as a hatter
Anticholinergic ADEs
fever, mydriasis (dilated pupils), xerostomia (dry mouth), dry eyes, decreased sweat, flushing, delirium)
142H in SITU, ABCDE Deep Veins
Antihistamine ADEs
h..............hypotension
h......hallucinations
s...............sedation
i...............increased appetite
15SHIVERS
Sx of serotonin syndrome
Shivering - one of the neuromuscular symptoms unique to SS
Hyperreflexia and myoclonus - especially notable in the lower extremities; muscular rigidity occurs only in more severe cases
Increased temperature - variable, caused by muscular hypertonicity
Vital sign instability - tachycardia, tachypnea, and/or labile blood pressure
Encephalopathy- AMS
Restlessness and incoordination
Sweating (diaphoresis) - autonomic response to excessive serotonin stimulation; by comparison, anticholinergic toxicity usually manifests with hot, dry skin
16TIRED
Sx of Hypoglycemia
Tachycardia
Instability
Restlessness
Excessive hunger
Diaphoresis/ Depression
17ACADEMIC FACS
Medications that interact with warfarin
Amiodarone
Ciprofloxacin/levofloxacin
Aspirin
Dicloxacilin
Erythromycin (macrolides)
Metronidazole (azole antifungals)
Indomethacin
Clofibrates
Fibrates
Allopurinol
CYP2C9 interactions
Statins
18ADIE
Medications that increase serum levels of simvastatin
Amiodarone
Diltiazem/ Verapamil
Itraconazole
Erythromycin/ Clarithromycin
19K-BANK
Things that increase K+ levels
K+ sparing diuretics
Beta blockers
ARBs/ACEI
NSAIDs
Kidney dx
20CAPTOPRIL
ADE of ACEI
Cough
Angioedema
Proteinuria/ K excess
Taste changes
Orthostatic hypotension
Pregnancy contraindication/ pancreatitis
Renal failure/ rash
Indomethacin inhibition
Leukopenia/ liver toxicity
21BECLOMETHASONE
ADE of steroids
Buffalo bump
Easy bruising
Cataracts
Larger appetite
Obesity
Moonface
Emotional changes
Thing arms and face
Hyperglycemia/ hypertension/ hirsutism (hairy)
Aseptic necrosis
Skin
Osteoporosis
Negative nitrogen balance
Extended wound healing
221 Heart, 2 Lungs
Site of beta-receptors/ B-neurotransmitter activity
B1 = heart
B2 = lungs, liver, smooth muscle, skeletal muscle, uterus, GI tract
B3 = adipose tissues
Pulling 2 ends of a string = constriction
23Unzipping 1 zipper = dilation
A2 agonist = constriction, effects on neuro and peripheral, use in HTN/ opiate withdrawal (ex: Clonidine)
A1 antagonist = dialation, effects on peripheral, use in BPH
24BZDs not hepatically cleared
"Over the liver"
Oxazepam, temazepam, lorazepam
25BZDs safe for elderly
"LOT"
Lorazepam, oxazepam, temazepam
26Ertapenem doesn't cover APE (Acinetobacter, Pseudomonas, Enterococcus)
Meropenem, doripenem, and imipenem-cilastin cover these
HIT MAP: All uppercase letters covers drugs causing DILE (3Ms) or
27My Pretty Pony Miss Muffin the Queen Is A Terrific Horse
Hydralazine
Isoniazid
Terbinafine
methimazole
Minocycline
Methyldopa
Anti TNF
Propylthiouracil
Quinidine
Methimazole
Procainamide
Propylthiouracil
Methyldopa
Minocycline
Quinidine
Isoniazid
Anti-TNF agents
Terbinafine
Hydralazine (alone, & in BiDil)
28Protease inhibitors not safe with sulfa allergies-monitor closely. NOT c/i thought
PAL: Prezista, Aptivus, Lexiva (daru, tipra, fosampre -navir)
29Very Questionable FACTS( all uppercase letters) covers TTP
Famciclovir, Acyclovir,Clopidogrel, Ticlopidine, SMX/TMP( FACTS) Valacyclovir (very) , Quinine ( Questionable)
30"My Good Lungs"- respiratory fluroquinolonges
Moxi, gemi, levofloxacin
31"PE- physical exercise" are PPI available as injectable
pantoprazole, esomeprazole
32"ROME"- acid-base abnormalities
Respiratory Opposite:
inc pH, dec CO2 (Alkalosis)
dec pH, inc CO2 (Acidosis)
Metabolic Equal"
inc pH, inc HCO3 (alkalosis)
dec pH, dec HCO3 (Acidosis)
33"C-WARD"- BZD side effects
C-confusion
W-withdrawl symptoms
A- addiction, amnesia, ataxia
R- rebound effect
D- drug abuse, dizzy, drowsy
34"WAOI"- MAOI side effects
W- weight gain
A- anticholinergic
O- orthostatic HTN
I- insomnia
35Drugs that cause a.fib. "PIRATES"
P-pulmonary disease (COPD, PE)
I- Ischemia (ACS)
R- rheumatic heart disease (mitral stenosis)
A-anemia
T- thyrotoxicosis
E-ethanol, endocarditis, electrolyte imbalance
S- sepsis, sick sinus syndrome
36Anticoag
direct thrombin inhibitors- BAD
Direct Xa inhibitors- ARE
Indirect Xa inhibitors- FED
DEAR- do not require monitoring in selected patients.
Switching from warfarin to DEAR when INR is 2,2.5,2,3 respectively
e.g. You can switch from warfarin to Rivaroxavan when INR<3( see the R in DEAR is for rivaroxaban)
37PI that require boosting "S.T.D."
Saquinavir, tipranavir, darunavir
38"Never go BACk to aBACavir"
Do not rechallenge if you Develop a severe rash. Screen for HLA-B*5701 first.
39Lithium drug interactions remember: "TALANS"
thiazides, ace, loop diuretics , ARBS, nsaids and sodium
40Pneumonic for drugs that cause pulmonary fibrosis- "BBC London"
Bleomycin, Busulfan, carmustin and lomustin
41Drugs that cause gout: "DANCe"
Diuretic
Aspirin
Niacin
Cytotoxic drugs
42Antibiotics with photosensitivity: "Too much f***ing sunlight"
-Tetracyclines
-Macrolides
-Fluroquinolones
-Sulfonamides
43Nterferon Alfa may cause or exacerbate
I- Ischemic or infectious
N- Neuropsychiatric
A- Autoimmune disorders
44IV drugs incompatible with PVC bags: "T-NAIL" or LATTINS
Tacrolimus, Taxanes (*except Abraxane*), nitroglycerin, amiodarone, insulin, lorazepam, sufentanil
45Only protease inhibitor with black boxed warning for hepatotoxicity:
Tipranavir
- imagine the tip of the liver being black
(they all cause hepatotoxicity, but this one is the only with a black boxed warning)
46Protease inhibitors with SJS/TENS warning
"D.F"- darunavir and fosamprenavir
(DF sounds like DaFt punk and they wear their masks to cover their severe skin reactions)
47Possible drug causes of hypotension "CRASH"
C: clonidine, CCB
R: reserpine
A: antidepressants, aminophylline
S: sedative hypnotics
H: heroin
*B-Vitamins:*
48To Read NewsPAPers, Be Fully Comprehensive
To - Thiamine (B1)
Read - Riboflavin (B2)
News - Niacin (B3)
PAp - Panthothenic Acid (B5)
Pers - Pyridoxine (B6)
Be - Biotin (B7)
Fully - Folate/Folic Acid (B9)
Complete - Cyanocobalamin (B12)
*Least Potent --> Most Potent Systemic Steroids + Dose Equivalency:*
49Cute, Hot Pharmacists & Physicians Marry Together & Deliver Babies
Short-Acting:
Cortisone 25 mg
Hydrocortisone 20 mg
Intermediate-Acting:
Prednisone 5 mg
Prednisolone 5 mg
Methylprednisolone 4 mg
Triamcinolone 4 mg
Long-Acting & Highest Potency:
Dexamethasone 0.75 mg
Betamethasone 0.60 mg
*Levothyroxine Tablet Colors:*
50Orangutans Will Vomit On You Right Before They Become Large, Proud Giants
All in MCG:
Orange: 25
White: 50
Violet: 75
Olive: 88
Yellow: 100
Rose: 112
Brown: 125
Turquoise: 137
Blue: 150
Lilac: 175
Pink: 200
Green: 300
*Statin Equivalent Doses:*
51Pharmacists Rock At Saving Lives and Preventing Flu
*ALL MOD. INTENSITY:*
Pitavastatin 2 mg
Rosuvastatin 5 mg
Atorvastatin 10 mg
Simvastatin 20 mg
Lovastatin 40 mg
Pravastatin 40 mg
Fluvastatin 80 mg
*Major CYP 450 Inducers:*
52PS PORCS
PHT (DILANTIN)
Smoking
Phenobarbital (LUMINAL)
Oxcarbazepine (TRILEPTAL)
Rifamycins
Carbamazepine (TEGRETOL, EQUETRO)
St. John's Wort
*Major CYP 450 Inhibitors:*
53G PACMAN
Grapfruit
PI's
Azoles
Cimetidine, cyclosporine, cobicistat
Macrolide abx (not azithromycin)
Amiodarone (+ dronedarone)
Non-DHP CCBs (verapamil & diltiazem)
*Worst drugs to combine with warfarin:*
54AlL FLAMES
Alcohol
Levothyroxine
Fluconazole
Levofloxacin
Amiodarone
Metronidazole
Erythromycin
Sulfa drugs
*Causes of high anion gap (>12) metabolic acidosis:*
55CAT MUDPILES or CUTE DIMPLES
CAT MUDPILES
*CO/Cyanide/CHF*
*Aminoglycosides*
*Theophylline/Toluene*
Methanol
Uremia
DKA
Paraldehyde/Paracetamol (APAP)
Infection/Iron/Isoniazid
Lactic acidosis
Ethanol/ethylene glycol
Salicylate OD
CUTE DIMPLES
Cyanide
Uremia
Toluene
Ethanol (alcoholic ketoacidosis)
DKA (diabetic ketoacidosis)
Isoniazid
Methanol
Propylene glycol
Lactic acidosis
Ethylene glycol
Salicylates
*Dialysis Indications:*
56AEIOU
Acidosis, metabolic
E-lytes (high K, Ca, Mg)
Ingestions (ex. ASA, ethylene glycol)
Overload (pulmonary edema)
Uremia (encephalopathy, pericarditis)
*Chemotherapy agents that must be taken with food or 1 hr after meal:*
57Can I Eat That?
Capecitabine
Imatinib
Exemestane
Thalidomide
58COX-2 selective inhibitors
MEN have COX
Meloxicam Etodolac Nabumetone Celecoxib
59beta blockers for migraine ppx
Miss The Pain
Metoprolol, Timolol, Propranolol
60Antiepileptic drugs for migraine ppx
TV
watch some tv w/o ya migraine
VPA, Topiramate
61Tigecycline dont cover
Ps
Proteus, pseudo, providencia
62triptans to avoid w/ maoi
ZIM
Zomig, IMitrex, Maxalt
63Beta 1 selective blockers
AMEBBA
Atenolol, Metoprolol, Esmolol, Bisoprolol, Betaxolol, Acebutolol
64Drugs for ACS
MONA-GAP-BA
Morphine, O2, Nitrates, Aspirin, G2b/3a receptor antags, Anticoag, P2Y12 inhibs, beta blockers, ace inhibitors
65Vaughan Williams Classification-Arrhythmia Meds
Double Quarter Pounder Lettuce Mayo Fries Please Because Dieting During Stress Is Always Very Difficult
Class 1a: disopyramide, quinidine, procainamide
1b: lidocaine, mexiletine
1c: flecainide, propafenone
Class 2: Beta blockers
Class 3: Dronedarone, dofetilide, sotalol, Ibutilide, amiodarone
Class 4: Verapamil, Diltiazem
66Conversion from warfarin to oral anticoagulants. Stop warfarin and start READ when INR is _
READ
Rivaroxaban when INR <3
Edoxaban when INR ≤2.5
Apixaban when INR <2
Dabigatran when INR <2
67Warfarin Tab colors
Please Let Greg Brown Bring Peaches To Your Wedding
Pink 1mg
Lavender 2mg
Green 2.5 mg
Brown/tan 3mg
Blue 4mg
Peach 5mg
Teal 6mg
7.5 mg Yellow
10mg White
Anxiolytic--Benzodiazepines: 6/8 listed
68When you're anxious you need "Double TLC and some AC."
There are 8 drugs on the list, a bunch of them end in "-azepam." Make one mnemonic for the "-azepam" drugs (the ones with similar suffixes) and another mnemonic for the remaining drugs.
When you're feeling ANXIOUS you need "double the TLC." :
"TLC" stands for:
Temazepam
Lorazepam
Clonazepam
The "double" TLC refers to the "Di" in Diazepam. ("Di" means two, which is double!)
For the other two drugs, think—anxiety makes you sweat. Turn on the AC! :
When you're feeling anxious you need "double the TLC and to turn on the AC." :
AC stands for:
Alprazolam (also,starts with "Alp," makes me think of being scared of heights/anxious in the Alps)
Chlordiazepoxide
So, when you're ANXIOUS you need
"Double TLC and AC."
1. Diazepam
2. Temazepam (extra)
3. Lorazepam
4. Clonazepam
5. Alprazolam
6. Chlordiazepoxide
Clorazepate (Tranxene)
Midazolam (Versed)
Oxazepam (Serax)
69Antidepressants--SNRI: 4 drugs
Vexed & Depressed - Venlafaxine (Effexor) & Duloxetine (Cymbalta or Irenka)
- the mnemonic includes the main indications: Generalized Anxiety Disorder (Vexed) and Major Depressive Disorder (Depressed)
Other 2:
Desvenlafaxine (Pristiq)
Levomilnacipran (Fetzima)
70Antidepressants--TCA
They are TRICYCLIC, (and hey! 2 of them have "-triptyline" in them) and "-pramine" plus doxepin
Amitryptyline (Elavil)
Nortriptyline (Pamelor)
Protriptyline
Trimipramine
Desipramine
Imipramine
Doxepin
71Antidepressant--SSRI: 6 drugs
Effective - Escitalopram
For - Fluoxetine, Fluvoxamine
Sadness, - Sertraline
Panic, - Paroxetine
& Compulsions - Citalopram
- the mnemonic includes the main indications: Depression (Sadness), Anxiety disorders & PTSD (Panic), and OCD (Compulsions).
72Monoamine Oxidase Inhibitor BRAND names (MAOIs)
PaNaMa EMS (PArnate, NArdil, MArplan, EMSam)
73Take WITH food-HIV meds
CoRN (these & combos w/these:
- Co-cobicistat
- R-rilpi/etra -virine
- N-'navirs)
74Bradycardia, Hypotension Mgmnt: IDEA
Isoproterenol
Dopamine
Epinephrine
Atropine
75Tranylcypromine BRAND
PARNATE
(PROMISE to take the TRAIN to CY/see PA)
76Isocarboxazid BRAND
MARPLAN (ISO CAR to MARs)
77Selegiline BRAND
EMSAM (STAY on the LINE for EMS)
78ACEi Side Effects
*CAPTOPRIL*
Cough
Angioedema
Potassium excess
Taste changes
Orthostatic hypotension
Pregnancy contraindication/Pressure drop (hypotension)
Renal failure/Rash
Indomethacin inhibition
Leukopenia (rare)
79ACEi Contraindications
*PARK*
Pregnancy
Allergy/Angioedema
Renal artery stenosis/Renal failure
K - hyperkalemia (potassium > 5.5)
80Steroid equivalents
"Big Dinosaurs Trample My Poor House Cats"
0.75 Betamethasone
0.75 Dexamethasone
4 Triamcinolone
4 Methylprednisone
5 Prednisone
20 Hydrocortisone
25 Cortisone
815 G's (natural products) that increase bleeding risk
o Gingko
o Garlic
o Ginger
o Glucosamine
o Gingseng
82Common Drugs that require SALINE only
ACID APE
♣ Ampicillin
♣ Caspofungin (Cancidas)
♣ Infliximab (Remicade)
♣ Daptomycin (Cubicin)
♣ Ampicillin/ sulbactam (Unasyn)
♣ Phenytoin
♣ Ertapenem (Invanz)
83Common Drugs that require dextrose only
BOAS
♣ Bactrim (Sulf -TMP)
♣ Oxaliplatin
♣ Ampotericin B
♣ Synercid (quinupristin/dalfopristin)
84Drugs that require a filter
GAL PLAT - 0.22 micron filter during administration
o Golimumab
o Amiodarone
o Lorazepam*
o Phenytoin*
o Lipids - 1.2 micron
o Amphotericin B (lipid formulations) - prepare using 5-micron filter
o Taxanes (except docetaxel)
*filters when administered by continuous infusion; not required for IV push
85Do not refrigerate
Dear Sweet Pharmacist, Marry Me Forever, Eternally. (Don't cool this love down. These IV drugs are not refrigerated)
o Dexmedetomidine (Precedex)
o Sulfamethoxazole/Trimethoprim
o Phenytoin
o Metronidazole
o Moxifloxacin (Avelox)
o Furosemide
o Enoxaparin
*Optional: diluted dexmedetomidine can be kept cold
Others: acetaminophen, acyclovir - crystallizes, deferoxamine - precipitates, levetiracetam, pentamidine - crystallizes, valproate
86Live vaccines
*COZY IV RM*
Cholera
Oral typhoid
Zoster
Yellow Fever
Intranasal flu
Varicella
Rotovirus
MMR
87Protect from light
(Deliver Every Needed Medication with Protection)
o Doxycycline
o Epoprostenol (Flolan)
o Nitroprusside (Nitropress)
o Micafungin (Mycamine)
o Phytonadione
88Hyperthroidism treatment in pregnancy
(Pregnant before become Mother)
o Propylthiouracil in 1st trimester
o Methimazole in 2nd and 3rd trimester
89Lipophilic antibiotics
(Mom Quit Listening To Rap)
o Macrolides
o Quinolones
o Linezolid
o Tetracyclines
o Rifampin
90Dimorphic fungi
(AMNS)
o Amiodarone
o Methotrexate
o Nitrofurantoin
o Sulfasalazine
91Severe & rare adverse effects of estrogen
ACHES
o Abdominal pain is severe
o Chest pain
o Headaches
o Eye problems
o Swelling or sudden leg pain
92Morphine type allergy
cross-react if have *cod* or *morph* or *norph* in name
93Treatment approach for stable ischemic heart disease
A - antiplatelet and antiangal drugs
B - blood pressure and beta blockers
C - Cholesterol (statins) and cigarettes (cessation)
D - diet and diabetes
E - exercise and education
94Drugs that cause or worsen heart failure
*D*rug *I*nformation *NATION*
o Dipeptidyl peptidase 4 inhibitors (DPP-4 inhibitors) -alogliptan, sitagliptan
o Immunosuppressants (TNF inhibitors - etanercept, rituximab; interferons)
o Non-DHP CCBs
o Anti-arrhythmics (class I agents)
o Thiazolidinediones (increase edema)
o Itraconazole
o Oncology agents (anthracyclines)
o NSAIDs (all including celecoxib)
95VinCristine toxicity
VinCristine = CNS toxicity
96VinBlastine and VinorelBine side effect
VinBlastine and VinorelBine = Bone marrow suppression
97antipsychotics with increased Prolactin levels
ris*P*eridone, *P*aliperidone
98Benzodiazepines to UN-do anxiety
UN-*CLAD*
Clonazepam
Lorazepam
Alprazolam
Diazepam
99Benzodiazepines for sleep
lorazepam or temazepam
100non-benzes to help falling asleep and staying asleep
*EZ* TIP for excellent sleep
Eszopiclone
Zolpidem
Lamictal starter kit
Orange
Blue
101Green
Orange- standard dosing
feeling "BLUE" = start lower dose if used with valproic acid
GREEN means "go" = higher dose if used with inducers
102moosh with no push
stool is not hard but cannot push it out = use stimulant alone
103BS- This hunky pharmacist needs sugar to maintain his ABS; only dextrose for him. (Common drugs with diluent solution requirements- Dextrose- No saline)
Amphotericin B
Bactrim
Synercid (Quinupristine/Dalfopristin)
104Pushy Guys in LA LA land (Common drugs with filter requirements- most require 0.22 micron filter during admin)
Phenytoin
Golimumab (Symponi)
Lipids (1.2 micron)
Amphotericin B (lipid formulations- 5 micron)
Lorazepam
Amiodarone
105Warning Signs of Skin Cancer
ABCDE (Asymmetry, Border, Color, Diameter, Evolve)
106Max Dose Chemo
1- Bleomycin 400 units (Pulmonary Toxic)
2- Doxorubicin 450-550 mg/m2 (Cardio Toxic)
3- Capecitabine 100 mg/m2 (Nephrotoxic)
4- Vincristine 2 mg per dose (Neuropathy)
107HIV with food
COGS (Complera, Odesy, Genvoya, and Staribid)
108HIV Classes
ends with VIR (NRTI)
VIR in the middle (NNRTI)
ends with Navir (PI)
ends with Gravir (NSTI)
109HIV with NO food
FADIE (Fosamprenavir, Atripla, Didanosine, Indinavir, and Efavirenz)
110HIV drugs NOT approved for HBV
DOG (Descovay, Odyssa, Genvoya) anything with TAF is not approved for HBV
111HIV drugs FOR HBV
LET (Lamavudine, Emtricitabine, Tenofovir)
EMT (200 mg) and TDF (300 mg) will treat both HIV and HBV but Lamavudine will need higher dose for HIV
112Only HIV drug that is Teratogenic
Efavirenz (Sustiva) or Atripla (Efa, EMT and TDF)
113All PPI with food except
Fosamprenavir
114PPI to avoid with Sulfa Allergy
DTF (Darunavir, Tipranavir, Fosamprenavir)
115HIV drugs to avoid with PPI
RAR (Rilpavirine, Ataznavir, Ritonavir)
116List High Alert drugs
Insulin (SQ or PO), Anticoagulants, conc electrolyte, antiarrhythmics, anesthetics, chemo, opioids, inotropic, and epidural or intrathecal meds
117Drugs with Photosensitivity
CA FRIENDS (Cyclosporine or Tacrolimus, Amiodarone, Fluorouracil, Retinoids, Isotretinoin, E is for something, NSAIDS, D (Loop and Thiazide), St. John wart
118Drug with TEN/ JSS
LAPPPS (Lamotrigine, Allopurinol, Phenytoin, Penicillin, Priopacxam, Sulfamethoxazole)
119Drugs exhibit Michel Menton Kinetics (3)
Phenytoin, Theophylline, Voriconazole (all exhibit saturate kinetics and non liner relationships)
120Book Colors
1- Orange Book (FDA): interchangeable drugs
2- Pink Book (CDC): vaccine preventable disease
3- Purple Book (FDA): biological drugs
4- Red Book (Micromedex): drug pricing
5- Red Book (AAP): pediatric ID, vaccines and ABX
6- Yellow Book (CDC): international traveling
7- Green Book (FDA): animal drug products
8- Pink Sheet: deals with legislative regulation and business development
121Max Vitamins
1- Vit E: 400 IU daily
2- Vit D = 600 IU
3- Ca for women 19-50 = 1000 mg
4- Ca for women > 50 = 1200 mg
5- Folic Acid = 400 mcg (1 month before preg), 600 mcg (2-3 months into preg), prenatal vit contains 1 G
122Common Teratogenic Agents
1- Acne (Retinoids and Isotretinoin)
2- BP and Chole (ACEI, ARBS, Statin)
3- Birth Control
4- Anticoagulants (DOAC and Warfarin)
5- Migraine (Dihydroergotamine and Ergotamine)
6- ABX (FQ and Tetracycline)
7- Others (MTX, Hydroxyurea, Lithium, Misoprostol, Valproic Acid, Thalidomide and weight loss)
123Vesicant
Vasopressors (dopamine, NE)
Anthracyclines (doxorubicin)
Vinka alkaloids (vincristine, vinblastine)
Others: digoxin, nafcillin, foscernet
124Alternate non-PVC Containers
Polyolefin
Polypropylene
Glass containers
125High-Risk Incompatibilities
Ceftriaxone & Calcium-containing solutions (includes Lactated Ringers)
Calcium & Phosphate- cause precipitation, could lead to death. Methods to prepare both
Others: Amphotericin B & sodium bicarb; Zosyn & many IV drugs; Heparin & many; Caspofungin & many.
126Lipophilic BBs (cause more CNS AEs like depression and fatigue
Nonselectives but swap nado for nebiv, and swap timo for meto
127Hydrophilic BBs
atenolol (if you're drinking water instead of alcohol, you'd say, she's a ten? lol)
128ARBs with amlo and HCTZ for triple combo HTN drugs
OV for olmesartan and valsartan (like OVechkin scored a hat trick which is triple goals)
129CCBs that cause constipation
Cardizem and Calan Cause Constipation
130Aliskiren diarrhea
I gotta SKIRY off to the bathroom real quick
131Statins that can't be used with cyclosporine (CI)
LIpitor and LIvalo (and simva of course)
warfarin and CYP2C9 inhibitors --> can increase INR:
132"the MAT drugs
Metronidazole
Amiodarone and Azole antifungals
Trimethoprim/sulfamethoxazole (TMP/SMX)
SEs of morphine:
133MORPHINES
Miosis
Orthostatic hypotension
Respiratory depression
Pneumonia
Histamine release/Hormone changes
Infrequency (constipationrination)
Nausea
Emesis
Sedation
conversion between aminophylline and theophylline:
134ATM
aminophylline to theophylline: multiply by 0.8
[theophylline to aminophylline: divide by 0.8]
functions of parasympathetic nervous system: (cholinergic)
135SLUDD + E
Salivation
Lacrimation
Urination (bladder contraction)
Digestion (peristalsis)
Diarrhea/defection (peristalsis)
Emesis
common resistant pathogens:
136Kill Each And Every Strong Pathogens
Klebsiella pneumoniae (ESBL, CRE)
Escherichia coli (ESBL, CRE)
Acinetobacter baumannii
Enterococcus faecalis, Enterococcus faecium (VRE)
Staphylococcus aureus (MRSA)
Pseudomonas aeruginosa
characteristics of tigecycline:
137"3 T's" and "5 P's"
Tigecycline, Tissue, Tangerine (after reconstitution)
does NOT cover Pseudomonas, Proteus, Providencia
138Severe and rare adverse effects of combined hormonal contraception
ACHES
Abdominal pain that is severe (ruptured liver tumor, cyst, ectopic pregnancy)
Chest pain (sharp, crushing, or heavy pain [MI] or SOB [blood clot in lungs])
Headaches (stroke)
Eye problems (blood clot in eye)
Swelling or sudden pain in legs (blood clots in legs)
139Steps for treating severe hyperkalemia
1. Stabilize the heart - prevent arrhythmias with Calcium Gluconate
2. Move it - shift excess K intracellularly with Regular Insulin, Dextrose
3. Remove it - enhance K elimination with Furosemide or SPS
140Characteristic motor symptoms of Parkinson's Disease (PD)
TRAP
Tremor
Rigidity
Akinesiaradykinesia
Postural Instability
141Drugs that decrease BP
Antihypertensives
Vasodilators
Opioids
Benzodiazepines
Anesthetics
Phosphodiesterase inhibitors
142Drugs that decrease HR
Beta blockers
Non-DHP CCBs (verapamil, diltiazem)
Digoxin
Clonidine, guanfacine (also used in ADHD)
Class 3 Antiarrhythmics
Opioids
Sedatives
Anesthetics
Neuromuscular blockers
Acetylcholinesterase inhibitors
143Drugs that increase HR
Stimulants
Decongestants
Beta agonists (albuterol)
Theophylline (esp. in toxicity)
Anticholinergics (TCAs, antihistamines)
Bupropion (Zyban)
Antipsychotics
Excess caffeine, nicotine, illicit drugs
Vasodilators (nitrates, hydralazine, DHP CCBs) can cause reflex tachycardia!
144Drugs that cause respiratory depression
Opioids
Sedatives - benzos, barbiturates ("barbital"), eszopiclone (Lunesta), zaleplon (Sonata)
145Drugs that can cause hyperthermia (increase temp)
Antipsychotics
Topiramate (Topamax)
146Temperature Conversions
C = (F - 32)/1.8
F = (C x 1.8) + 32
147Drugs that can worsen insomnia
Alcohol
Bupropion
Caffeine
Decongestants (Sudafed)
Diuretics (due to nocturia)
Fluoxetine (if taken late in the day)
Steroids
Stimulants
Varenicline (Chantix)
148Drugs that can worsen PD:
Phenothiazines - like prochlorperazine
Haloperidol
Risperidone (Risperdal)
Paliperidone
Metoclopramide
149Drugs that can worsen BPH
anticholinergics (Cogentin)
antihistamines (diphenhydramine)
caffeine
decongestants
diuretics
SNRIs
TCAs
testosterone products
150Drugs that's increase uric acid (UA):
ASA (higher doses)
Diuretics (loop and thiazides)
Niacin
Pyrazinamide
Calcineurin inhibitors (tacrolimus, cyclosporine)
Select chemotherapy
Select pancreatic enzyme products
151Drugs that can cause ED:
Alcohol
antidepressants (SSRI and SNRI)
antihypertensives (beta blockers, clonidine)
antipsychotics (risperdal, paliperidone)
BPH meds (finasteride, dutasteride)
152Drugs that are teratogenic
Alcohol
Anticoagulants- warfarin
anticonvulsants- VPA, Topamax
cancer drugs
isotretinoin & topical retinoids
tetracyclines & quinolones
Statins
RAAS inhibitors- ACEIs, ARBs, aliskiren, Entresto
Most all hormones
Ergotamines
Hydroxyurea
Lithium
Methotrexate
Misoprostol
Paroxetine
Ribavirin
Thalidomide
Weight loss drugs
153MRSA Coverage
Very Talented Dalmatians Like To Climb Down Bright Red Cars
Vancomycin
Telavancin
Daptomycin
Linezolid
Tigacyl
Clindamycin
Doxycycline
Bactrim
Rifampin
Ceftaroline
154Enterococcus Coverage
Very Talented Dalmatians Like To Crawl Under Red Zebras
Vancomycin
Telavancin
Daptomycin
Linezolid
Tigacyl
Carbapenems (except Erta)
Unasyn
Rifampin
Zosyn
155Pseudomonas Coverage
Cici Can Consume Carbs And Pizza Like Gentlemen
Ciprofloxacin
Ceftazidime (3rd)
Cefepime (4th)
Carbapenems (except Invanz)
Aztreonam
Pip/Tazo
Levofloxacin
Gentamicin/Tobramycin
156Anaerobe Coverage
Tigers Move Under Me Climbing Past Cars
Tygacil
Moxifloxacin
Unasyn
Metronidazole
Clindamycin
Pip/Tazo
Carbapenems (all)
157Atypical Coverage
Tigers Move Az Dogs Leave Lima
Tygacil
Moxifloxacin
Aztreonam
Doxycycline
Levofloxacin
Linezolid
Depression diagnosis
158M SIG E CAPS
Mood - depressed
Sleep - hyper/hypo
Interest/Pleasure - dec
Guilt or feeling of worthlessness
Energy- dec
Concentration - dec
Appetite - inc/dec
Psychomotor agitation or retardation
Suicidal ideation
s/sx of stroke
159FAST
Face
Arm
Speech
Time
Drug that cause more hypoglycemia than other antidiabetc
160SMIP
Sulfonylureas
Meglitinides
Insulin
Pramlinitide
Antidiabetic drugs that cause weight loss
161PiGS (without I)
Pramlinitide
GLP-1 agonists
SGLT-2 anta
Antidiabetic drugs that cause weight gain
162SMIT
SU
Meglitinides
Insulin
TZD
Antidiabetic drugs that come as injectables
163PIG
Pramlinitide
Insulin
GLP-1 anta
Work by increasing insulin secretion
164SIM
SU
Insulin
Meglitinides
Antidiabetic drug that act on Glucagon and thus dcrease glucose production
165GDP
GLP-1 ag
DPP-4 anta
Pramlinitide
Decrease postprandial glucose
166MAD-ProGram
Meglitinides
Alpha-glucosidase inhib
DPP-4 anta
Pramlinitide
GLP-1 Anta
Classes of antibiotics.
167"Antibiotics Can Certainly Protect The Nordic Queens Servants, Men, and Guards"
Aminoglycosides (Ex: Gentamycin, Tobramycin, Streptomycin, Neomycin)
Cephalosporins (Ex: Cephalexin, Ceftriaxone).
Carbapenem (Ex: Meropenem, Ertapenem, Doripenem)
Penicillins (Ex: Penicillin, amoxicillin, nafcillin)
Tetracyclines (Ex: Doxycycline).
Nitroimidazole (Ex: Metronidazole)
Quinolones/Fluroquinolones (Ex: Ciprofloxacin)
Sulfonamides (Ex: Sulfamethoxazole, often combined with Trimethoprim to make Bactrim).
Macrolides (Ex: Azithromycin, Erythromycin, Clarithromycin)
Glycopeptides (Ex: Vancomycin, Telavancin, Dalbavancin).
Bacteriostatic Antibiotics
168ECSTaTiC
Erythromycin
Clindamycin
Sulfamethoxazole
Trimethoprim
Tetracyclines
Chloramphenicol
169TriMethoPrim (Side effects)
Treats Marrow Poorly:
Megaloblastic anemia
Leukopenia
Granulocytopenia
170SAFE Moms Take Really Good Care. Kitchen Oil Can CHar Multiple Teeth To Turn Gray.
Sulfonamides - Kernicterus.
Aminoglycosides - Ototoxicity.
Fluoroquinolones - Cartilage.
Erythromycin -Cholestatic hepatitis.
Metronidazole - Mutagenesis.
Tetracyclines - Teethones.
Ribavirin - Teratogenic.
Griseofulvin - Teratogenic.
Chloramphenicol - Gray baby.
171Do NOT use with color change
-Chlorpromazine = darker than slight yellow (slight yellow: potency retained, ok to use)
-dacarbazine= pink
-dobutamine= oxidation turns the solution slightly pink, but potency is not lost
-dopamine= darker than slight yellow (slight yellow: potency retained, OK to use; extravasation antidote: phentolamine)
-epinephrine: pink, then brown
-isoproteronol: pink or darker (damaged by air, light, heat)
-morphine: dark
-nitroprusside: orange --> brown --> blue
(blue indicates nearly complete dissocation to cyanide; antidote is Cyanokit)
-norepinephrine: brown or any discoloration (normal color: yellow/orange)
-tigecycline: greenlack
172IV drugs that come as colored solutions
-*anthracyclines = red
-IV iron = brown
-methotrexate = yellow
-*mitoxantrone = blue
-multivitamins for infusion (MVI) = yellow
-*rifampin = red
-tigecycline = yellow/orange
173Do NOT shake
-albumin, alteplase, immune globulins, insulins, rasburicase, some vaccines (zoster)
-quinupristin/ dalfopristin (Synercid) and etanercept form a foam and should be swirled when reconstituting. do not shake and wait for the foam to dissolve
174Protect from light during administration
Deliver Every Needed Medication (with a light-) Protective (cover)
D = Doxycycline
E = Epoprostenol
N = Nitroprusside
M = Micafungin
P = Phytonadione
Others: ampho b deoxycholate, anthracyclines, dacarbazine (if extravasates, protect exposed tissues from light), thiotepa, pentamidine