Chapter 24
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1
Eicosanoid, prostaglandin, thromboxane and leukotriene acts on an or . They do not travel to regulate elsewhere.
Eicosanoid, prostaglandin, thromboxane and leukotriene acts on an adjacent cell or themselves. They do not travel to regulate elsewhere.
2
All of the eicosanoids are or signaling molcules. They are synthesized in tissues.
All of the eicosanoids are autocrine or paracrine signaling molcules. They are synthesized in all tissues.
3
All of the eicosanoids are derived from
All of the eicosanoids are derived from arachidonic acid
4
Arachidonic acid is a C-20 compount with double bonds between
Arachidonic acid is a C-20 compount with double bonds between 5, 8, 11, 14
5
Arachindonic acid becomes using the enzyme
Arachindonic acid becomes 5-hydroperoxyeicostatetraenoic acid (5-HPETE) using the 5-lipoxygenase enzyme
6
The 5 lipoxygenase enzyme is inhibited by
The 5 lipoxygenase enzyme is inhibited by Zyflo (Zileuton)
7
causes the release of membranse bound arachidonic acid
Phospholipase A2 causes the release of membranse bound arachidonic acid 
8
Phospholipase A2 is inhibited by
Phospholipase A2 is inhibited by cortisol 
9
Arachidonic acid is converted to PG and TX by
Arachidonic acid is converted to PG and TX by COX
10
Archidonic acid is converted to LT by
Archidonic acid is converted to LT by lipoxygenase
11
COX-1 is found in
COX-1 is found in most tissues
12
COX-1 is needed for healthy , ,
COX-1 is needed for healthy gastric tissue, renal homeostasis, platelet aggregation
13
COX-2 is found in and
COX-2 is found in immune and inflammatory cells
14
COX-2 Mediates , , , , , and
COX-2 Mediates pain, heat, redness, swelling, inflammation, and fever
15
NSAID are inhibited by by blocking the production of parent
NSAID are inhibited by COX1 and COX2 by blocking the production of parent PGH2
16
Cortisol inhibits ONLY by blocking
Cortisol inhibits ONLY CoX-2 by blocking phospholipase A2
17
Prostacyclin (PGI2) are produced by that inhibit
and
stimulates and
blocks .
and
stimulates and
blocks .
Prostacyclin (PGI2) are produced by vascular
endothelial cells that inhibit
platelet aggregation and
stimulates vasodilation and
blocks thrombogenesis.
endothelial cells that inhibit
platelet aggregation and
stimulates vasodilation and
blocks thrombogenesis.
18
PGF2a is made by and is produced by the
PGF2a is made by most tissues and is produced by the corpus luteum.
19
PGF2a does Contraction of and stimulates
PGF2a does Contraction of Smooth Muscle and stimulates Uterine
Contraction
Contraction
20
Thromboxanes
A2 (TXA2) is
produced in .
TXA2 promotes adherence and
aggregation of and and
(thrombi)
formation.
A2 (TXA2) is
produced in .
TXA2 promotes adherence and
aggregation of and and
(thrombi)
formation.
Thromboxanes
A2 (TXA2) is
produced in activated platelets.
TXA2 promotes adherence and
aggregation of circulating
platelets and contraction of
vascular smooth muscle and
promotes clot (thrombi)
formation.
A2 (TXA2) is
produced in activated platelets.
TXA2 promotes adherence and
aggregation of circulating
platelets and contraction of
vascular smooth muscle and
promotes clot (thrombi)
formation.
21
While blocks platelet aggregation, promotes it
While PGI2 (prostacyclin) blocks platelet aggregation, TXA2 (thromboxane) promotes it
22
LTA4 is derived from
LTA4 is derived from 5-HPETE
23
LTA4 produced in . It is found in , , and
LTA4 produced in Leucocytes. It is found in Mast Cells, Platelets, heart and
lung
lung
24
LTB4 (Leucotriene B4) in increased . It functions to and .
LTB4 (Leucotriene B4) in polymorphonuclear
leucocytes increased chemotaxis. It functions to release lysosomal enzymes and adhere white blood cells.
leucocytes increased chemotaxis. It functions to release lysosomal enzymes and adhere white blood cells.
25
LTE4 (Leucotriene E4) is involved in ,
, Increased , and .
, Increased , and .
LTE4 (Leucotriene E4) is involved in Bronchoconstriction,
Vasoconstriction, Increased Vascular Permeability, and contraction of Smooth Muscle.
Vasoconstriction, Increased Vascular Permeability, and contraction of Smooth Muscle.
26
LTE4 (Leucotriene E4) is a Slow Reacting Substances of
LTE4 (Leucotriene E4) is a Slow Reacting Substances of Anaphylaxis (SRS‐A)
27
LTE4 (Leucotriene E4) inhibitors include and
LTE4 (Leucotriene E4) inhibitors include Accolate (Zafirlukast) and
Montelucast
Montelucast
28
Draw out the general schematic for asprin
Draw out the general schematic for asprin 
29
is used in which is used for treatment of asthma, excersise induced bronchospasm, and allergic rhinitis
Montelucast is used in sigulair which is used for treatment of asthma, excersise induced bronchospasm, and allergic rhinitis
30
Sphingolipid synthesis is initiated between and by . Results in the production of .
Sphingolipid synthesis is initiated between Palmitoyl CoA and L-serine by serine palmitoyl transferase (SPT) . Results in the production of sphingomyelin. 
31
Sphingolipid synthesis is initiated between and by . Results in the production of .
Sphingolipid synthesis is initiated between Palmitoyl CoA and L-serine by serine palmitoyl transferase (SPT) . Results in the production of sphingomyelin. 
32
What are the two compounds needed to synthesize sphingolipids?
Palmitoyl-CoA and L-Serine
33
What inhibits serine palmitoyl transferase?
Myriocin
34
What inhibits ceramide synthase?
Fumonisin B1
35
is a genetic skin disorder that affects males. It is an inborn error of metabolism characterized by a of the enzyme
X-linked ichthyosis is a genetic skin disorder that affects males. It is an inborn error of metabolism characterized by a deficiency of the enzyme steroid sulfatase