FINALS

113 flashcardsby CHRISTY
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1
An act authorizing the legacy or donation of all or part of a human body after death for specified purposes
Organ Donation Act (RA 7170)
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When did RA 7170 approved?
January 7, 1992
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a facility licensed, accredited or approved under the law for storage of human bodies or parts thereof
Organ Bank Storage Facility
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deceased individual, and includes a still-born infant or fetus
Decedent
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an individual who makes a legacy of all or part of his body
Testator
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individual authorized under this Act to donate all or part of the body of a decedent
Donor
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licensed, accredited or approval under the law, and includes, a hospital operated by the Government
Hospital
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includes transplantable organs, tissues, eyes, bones, arteries, blood, other fluids and other portions of the human body
Part
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individual, corporation, estate, trust, partnership, association, the Government or any of its subdivisions, agencies or instrumentalities, including government-owned or -controlled corporations; or any other legal entities
Person
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licensed or authorized to practice medicine under the laws of the Republic of the Philippines
Physician/Surgeon
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persons enumerated in Section 4 of this Act
Immediate Family of the Decedent
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irreversible cessation of circulatory and respiratory functions or the irreversible cessation of all functions of the entire brain, including the brain stem
Death
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A person shall be medically and legally dead if either:
In the opinion of the attending physician, based on the acceptable standards of medical practice, there is an:

▪absence of natural respiratory and
cardiac functions
▪attempts at resuscitation would not be successful
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A person shall be medically and legally dead if either:

2) In the opinion of the consulting physician, concurred in by the attending physician:
▪irreversible cessation of all brain functions
▪absence of such functions ▪further attempts at resuscitation
▪continued supportive maintenance would not be successful
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Fill in the blanks:

•shall be diagnosed separately by the attending physician and another ______ physician, both of whom must be appropriately qualified and suitably experienced in the care of such parties
•death shall be recorded in the _________
consulting physician, patients medical record
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Section 3
Person Who May Execute a Legacy
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Any individual, 18 years of age and of sound mind, may give by way of legacy, to take effect after his death, all or part of his body for any purpose specified in Section 6 hereof.

True or false:
True
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Section 4
Person Who May Execute a Donation
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PERSON WHO MAY EXECUTE A DONATION:
•Spouse
•Son or daughter of legal age •Either parent
•Brother or sister of legal age
•Guardian over the person of the decedent at the time of his death
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Section 5
EXAMINATION OF HUMAN BODY OR PART THEREOF
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shall be conducted on the cadaver immediately after the pronouncement of death:
• accident
• trauma
•other medico-legal cases
autopsy
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Purpose of autopsy:
determine qualified and healthy human organs for transplantation and/or in
furtherance of medical science
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Section 6
PERSONS WHO MAY BECOME LEGATEES OR DONEES
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for medical or dental education, research, advancement of medical or dental science, therapy or transplantation
hospital, physician or surgeon
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for education, research, advancement of medical or dental science, or therapy
accredited medical or dental school, college or university
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for medical or dental education, research, therapy, or transplantation; and
•organ bank storage facility
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for therapy or transplantation needed by him
specified individual
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Section 7
Duty of Hospitals
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Section 8
Manner of Executing a Legacy
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transfer of tissue from one site to another within an individual

regularly accepted by the body
autograft
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•transfer of tissue between genetically identicals
•usually taken permanently
isograft/syngeneic
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usually rejected unless the recipient is given immunosuppressive drugs
allograft/homograft
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transfer of tissue between two individuals of the same species
allograft/homograft
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- transfer of tissue between different species

- always rejected
heterograft/xenograft
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Types of transplant:
1. Kidney
2. Heart
3. Lung
4. Liver
5. Bone marrow
6. Pancreas
7. Skin
8. Peripheral blood stem cells
9. Cornea
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Complications include:
1.Bacterial,fungal,viralorparasitic infections or neoplasms
2. Chemotherapy or radiation therapy may also be toxic to organs
3. Graft vs. host disease (GVHD) can occur when new lymphocytes in bone marrow transplant are released into the peripheral blood
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easily grafted because they are avascular and lymphatic supply of the eye prevents many antigens from triggering an immune response
cornea
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In your graft vs host disease, Not a problem with heart and kidney transplants but only of _________
bone marrow transplants
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Occurs whenever there is an antigen difference between donor and recipient because the bone marrow can produce lymphocytes which can become sensitized to the recipient’s antigen
graft vs host disease
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Symptoms of Graft vs. Host Disease:
•Liver abnormalities
•Skin rash that looks like measles
•Diarrhea
•Wasting
•Death
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Methods to determine haplotype matching
DNA Sequencing through PCR
Serologic Assays
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highly specific and sensitive; method of choice
DNA SEQUENCING THROUGH PCR
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Cells of donor and recipient are reacted with a battery of antibodies for Class I or Class II MHC
Serologic assays
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Satisfactory method but fails to identify certain alleles that have been detected by DNA sequencing
Serologic assays
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Refers to the fate of cells, tissues, or organs transplanted between different individuals or from one individual to oneself
graft acceptance and rejection
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2 types of rejection:
First Set of Rejection
Second Set of Rejection
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•first time a graft is encountered and rejected
•immune system attacks and ultimately destroys the “non-self” tissue
•occur 10 – 14 days after transplantation
First set rejection
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•Second time the same set of non-self tissue is
encountered
•Rejected within 6 days
Second Set Rejection
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Clinical Indications of Graft Rejection
1. Hyperacute Rejection
2. Acute/AcceleratedRejection 3. ChronicRejection
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•Occurs within 24 hours
•There is rapid vascular spasms and vascular occlusions
hyperacute rejection
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•Occurs weeks of transplantation (10-30 days)
•Infiltration of small lymphocytes, mononuclear cells and granulocytes around small blood vessels of the graft
Acute or accelerated rejection
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Occurs months to years after transplantation
chronic rejection
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among siblings for both haplotypes shared
25% chance
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for 1 haplotype to be shared
50% chsnce
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for no haplotypes shared
25%
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Interfere with nucleic acid metabolism of the mononuclear cells
AZATHRIOPRINE, CYCLOSPHOSSPHAMIDE, METHOTREXATE
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Anti-inflammatory drugs that decrease the number of lymphocytes
CORTICOSTEROIDS
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Prevents helper-cell activation
Cyclosphorin A
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Contains antibodies to kill lymphocytes in the recipient
Antilymphocyte serum
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• is a practical and normative science, based on reason, which studies human acts and provide norms for their goodness or badness
ethics
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likewise known as moral philosophy, moral rectitude or the rightness and wrongness of human acts
ethics
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ethics deals with a systematized body of knowledge that can be used, practiced and applied to human action
practical science
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considers the usefulness, practicality and application of human knowledge, which is simply interested in truth for its own sake, without any bearing on action and experience
practical science
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ethics establishes norms or standards for the
direction and regulation of human actions
normative science
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it is also known as special ethics
applied ethics
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Study of ethical issues and values not only in medicine and biology but also in the behavioral sciences
bioethics
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Oldest phase of bioethical exploration which is a formulation of ethical norms for the conduct of health care professionals in the treatment of patients
medical ethics
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Second phase in the development of bioethical study
research ethcs or biomedical research
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Refers to the use of humans as experimental specimens (e.g. prisoners, poor patients, children and fetuses)
research or bionedical research
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Third stage in the development of bioethical inquiry
public policy
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Accentuates the participatory aspect of decision-making in a democratic set-up with regard to the formulation of public policies for the benefit of all
public policy
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Refers to people’s efforts or involvement in formulating public guidelines for both clinical cases and biomedical research
public policy
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Done through surveys, meetings, conferences, convocations
public policy
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Practice of doing acts of goodness, kindness and charity
principle of beneficence
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Marks the significance of individual autonomy which mandates a strong sense of personal responsibility for one’s own life
principle of autonomy
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Right to self-determination giving emphasis to the moral right of an individual to determine what is good for himself/herself
principle of autonomy
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rendering of what is due or meited
principle of justice
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an individual or group receives is determined by balancing the competing claims of other individuals or groups
comparative justice
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•distribution of medical goods is determined by a certain standard rather than buy the needs or claims of individuals
•“First come, first served”
noncomparative justice
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stresses the ebd result, goal or consequence of an act.

also called consequential ethics
teleological
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stresses duty as the norm of moral actions; also known as duty ethics
deontological ethics
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• Also known as moral relativism
• No universal or absolute moral principles
ethical relativism
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Standards of right and wrong are always relative to a particular culture or society
ethical relativism
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By Joseph Fletcher (an American Protestant medical doctor)
situation ethics
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prescribes certain general laws or norms
legalism
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frees the Christian from the
obligations of the moral law
antinomianism
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moral norm depends upon a given situation, but whatever situation may be, one must always act in the name of Jesus Christ
situationism
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By Charles Peirce and William James
pragmatism
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More of the theory of knowledge, truth and
meaning than of morality
pragmatism
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Holds that the true and valid form of knowledge is one which is practical, workable, beneficial and useful
pragmatism
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by Jeremy Bentham and John Stuart Mill
utilitarianism
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The righteous and wrongness of actions is determined by the goodness and badness of their consequences
utilitarianism
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Principle of utility: “Actions are good insofar as they tend to promote happiness, bad as they produce unhappiness”
utilitarianism
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By Immanuel Kant
kants ethics
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Maintains that one acts morally of and only if one
does whatever one is obliged to do
kants ethics
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By William David Ross
ross ethics
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• “Kung nakagawa ka ng masama, gumawa ka ng mabuti.”
duty of reparation
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Proper distribution of social benefits and burdens
duty of justice
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• Contribute whatever small way we can to others
duty of beneficence
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• Not injuring others
• “Ang masakit sa iyo ay huwag mong gawin sa kapwa mo.”
duty of non malificence
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The greater good to be shared by all members should
not be used to justify the loss of freedom of others
rawls theory of justice
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After St. Thomas Aquinas (Thomistic/Scholastic ethics)

• “Do good. Avoid evil” through the voice of right reason or conscience
natural law ethics
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Either a thing (money) or action (surgical operation)
object
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Conditions which are superadded to the nature of moral act
circumstances
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•Affects the goodness or badness of an action or decision in a number of important ways
• A good act with a bad motive makes the moral action bad
end product
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refers to the moral and inviolable power vested in him/her as a person to do, hold or demand something as his own
patients rights
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Right to receive all necessary information concerning diagnosis and treatment
right to informed consent
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Refers to knowledge and information about the consent to a particular for of medical treatment
right to informed consent
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Content of what a patient is told or informed about
during the consent negotiation
disclosure
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Whether the information given has been understood
comprehension
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o Patient’s capacity for decision making
o One can choose between alternatives
o One can justify one’s choice
o One does not only justify one’s choice but does so in a reasonable manner
competence
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Information and understanding are necessary for genuine deliberation
right to informed consent
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Refers to the necessary information a patient should know about a medical treatment or experiment
right to informed consent
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