1operator
on/off switch segment of DNA
2operon
the entire stretch of DNA that has the operator, promoter, and genes they control
3repressor
a protein that prevents gene transcription by binding to the operator and blocking RNA polymerase
4corepressor
a molecule that cooperates with a repressor protein to switch an operon off
5repressible operon
on; shuts off transcription
6inducible operon
off; turns on transcription
7inducer
inactivates the repressor
8cyclic AMP receptor protein (CRP)
an activator of transcription
9differential gene expression
the expression of different genes by cells with the same genome
10histone acetylation
acetyl groups are attached to an amino acid in a histone tail
opens up the chromatin structure, promoting the initiation of transcription
11the addition of methyl groups(methylation)...
can condense chromatin and reduce transcription
12DNA methylation
the addition of methyl groups to certain bases in DNA
13epigenetic inheritance
the inheritance of traits transmitted by mechanisms not directly involving the nucleotide sequence
14control elements
segments of noncoding DNA that serve as binding sites for transcription factors that help regulate transcription
15enhancers
distal control elements
associated with only 1 gene
16activator
a protein that binds to an enhancer and stimulates transcription of a gene
have 2 domains(binds DNA and activates transcription)
17alternative RNA splicing
different mRNA molecules are produced from the same primary transcript
18microRNA(miRNA)
small, single-stranded RNA molecules that can bind complementary sequences in mRNA
19RNA interference
the blocking of gene expression by small interfering RNAs
20cell differentiation
the process by which cells become specialized in structure and function
21cytoplasmic determinants
maternal substances in the egg that influence early development
22induction
process where signal molecules from embryonic cells cause changes in nearby target cells
23determination
irreversibly commits a cell to becoming a particular cell type
24pattern formation
the development of a spatial organization of tissues and organs
25positional information
the molecular cues that control pattern formation
26homeotic genes
control pattern formation in the late embryo, larva, and adult stages
27maternal effect genes
encode cytoplasmic determinants that initially establish the axes of the body
28morphogen
establish an embryo's axes and other features of its form
29oncogene
mutations in genes that code for proteins that stimulate normal cell growth and division
30epigenetic changes
mutation in a gene for a chromatin-modifying enzyme can lead to loosening of the chromatin and inappropriate expression of a proto-oncogene
31translocation
gene moved to a new locus, under new controls
32gene amplification
multiple copies of the gene
33tumor suppressor genes
inhibit cell division
34what does mutations in the p53 gene cause?
prevents suppression of the cell cycle