Biology Ch.18

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1
operator
on/off switch segment of DNA
2
operon
the entire stretch of DNA that has the operator, promoter, and genes they control
3
repressor
a protein that prevents gene transcription by binding to the operator and blocking RNA polymerase
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corepressor
a molecule that cooperates with a repressor protein to switch an operon off
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repressible operon
on; shuts off transcription
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inducible operon
off; turns on transcription
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inducer
inactivates the repressor
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cyclic AMP receptor protein (CRP)
an activator of transcription
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differential gene expression
the expression of different genes by cells with the same genome
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histone acetylation
acetyl groups are attached to an amino acid in a histone tail
opens up the chromatin structure, promoting the initiation of transcription
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the addition of methyl groups(methylation)...
can condense chromatin and reduce transcription
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DNA methylation
the addition of methyl groups to certain bases in DNA
13
epigenetic inheritance
the inheritance of traits transmitted by mechanisms not directly involving the nucleotide sequence
14
control elements
segments of noncoding DNA that serve as binding sites for transcription factors that help regulate transcription
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enhancers
distal control elements
associated with only 1 gene
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activator
a protein that binds to an enhancer and stimulates transcription of a gene
have 2 domains(binds DNA and activates transcription)
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alternative RNA splicing
different mRNA molecules are produced from the same primary transcript
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microRNA(miRNA)
small, single-stranded RNA molecules that can bind complementary sequences in mRNA
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RNA interference
the blocking of gene expression by small interfering RNAs
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cell differentiation
the process by which cells become specialized in structure and function
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cytoplasmic determinants
maternal substances in the egg that influence early development
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induction
process where signal molecules from embryonic cells cause changes in nearby target cells
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determination
irreversibly commits a cell to becoming a particular cell type
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pattern formation
the development of a spatial organization of tissues and organs
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positional information
the molecular cues that control pattern formation
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homeotic genes
control pattern formation in the late embryo, larva, and adult stages
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maternal effect genes
encode cytoplasmic determinants that initially establish the axes of the body
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morphogen
establish an embryo's axes and other features of its form
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oncogene
mutations in genes that code for proteins that stimulate normal cell growth and division
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epigenetic changes
mutation in a gene for a chromatin-modifying enzyme can lead to loosening of the chromatin and inappropriate expression of a proto-oncogene
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translocation
gene moved to a new locus, under new controls
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gene amplification
multiple copies of the gene
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tumor suppressor genes
inhibit cell division
34
what does mutations in the p53 gene cause?
prevents suppression of the cell cycle
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