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1
a study of how novel drugs can be designed and developed.
medicinal chemistry
2
medicinal chemistry aka
therapeutic chemistry
3
interdisciplinary research area incorporating different branches of c_________ and ______ in the research for better and new drugs (Drug Discovery).
chemistry and biology
4
what type of origin is aspirin
synthetic
5
what type of origin is paracetamol
synthetic
6
what type of origin is chloroquine
synthetic
7
what type of origin is acetylsalicylic acid
synthetic
8
what type of origin is chlorpromazine
synthetic
9
what type of origin is ephedrine
synthetic
10
what type of origin is vincristine
natural in plants
11
what type of origin is taxol
natural in plants
12
what type of origin is digoxin
natural in plants
13
what type of origin is quinine
natural in plants
14
what type of origin is reserpine
natural in plants
15
what type of origin is ergotamine
natural in plants
16
what type of origin is ephedrine
natural in plants
17
what type of origin is colchicine
natural in plants
18
what type of origin is heparin
natural in animal
19
what type of origin is insulin
natural in animal
20
what type of origin is thyroid extracts
natural in animal
21
what type of origin is enzymes
natural in animal
22
what type of origin is
natural in animal
23
what type of origin is penicillin
natural in mircoorganism
24
what type of origin is streptomycin
natural in mircoorganism
25
what type of origin is tetracycline
natural in mircoorganism
26
what type of origin is human insulin
biosynthetic
27
what type of origin is interferon
biosynthetic
28
what type of origin is erythropoietin
biosynthetic
29
what type of origin is hepatitis vaccine
biosynthetic
30
it usually do not have any synthetic substitutes
plant based drugs
31
Antibiotics are mostly derived from a variety of ____________ and
soil fungi , bacteria
32
natural, in microoganism. These drugs form the most important group of ____________ agents used against infective diseases.
chemotherapeutic
33
are used as there are complex molecules that may be hard to synthesize and the process of creating these drugs may also be expensive and uneconomical. There are also instances wherein natural sources may be impure.
semi-synthetic
34
Several drugs are complex polypeptides. It is difficult to obtain these drugs in pure form from natural sources and are very expensive to synthesize in the laboratory.
biosynthetic
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are used most widely because of their inexpensiveness, ease of quality control, mass production and therapeutic efficacy. The synthetic drugs are prepared by chemical processes,
synthetic drugs
36
increase heart rate and causes dryness of the mouth
marijuana and atropine
37
is a depressant drug because of its depressant CNS action
alcohol
38
in alkanes answer the foll. question
aka.
MP, BP ,solubility,polarity, type of compound, in vivo, common reactions
lipid soluble, saturated HC paraffins, non polar. least reactive organic compound, stable in vivo, side chai undergo hydroxylation, combustion its end product is CO2 plus water, halogenation
39
in alkenes answer the foll. question
aka.
on shelf , type of compound, in vivo, common reactions
olefins, unsaturated HC , volatile alkenes + peroxide+ o= explode, combustion, addition , polymerization
40
addition reaction in which H2 is incorporated
hydrogenation
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addition reaction in which a halogen added/incorporated into molecules of an organic compound
halogenation
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a hydrogen halide is incorporated into molecules of an organic compound
hydrohalogenation
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Water is incorporated into molecules of organic compound
hydration
44
Specific calalyst are needed. A repetitous
combining of many small molecules which produces a very large molecule
polymerization
45
in addition what are the symmetrical and asymmetrical
sym- hydrogenation, halogenation
asym- hydrohalogenation, hydration
46
what does involve in addition and not
not- combustion
in- polymerization
47
hydration is
alcohol
48
hydrogenation is
alkene
49
halogenation is
dihaloalkene
50
hydrohalogenation is
monoaloalkene
51
in aromatic hc answer the foll. question
it is based on, solubility
on shelf , type of compound, in vivo, common reactions
benzene ring, lipid soluble, stable, unsaturated cyclic HC not undergo addition, hydroxylation, epoxidation, diol formation, undergo in substitution reaction which is alkylation and halogenation
52
an alkyl group substitutes for a hydrogen atom on the
benzene ring. This is considered as the most important industrial
reaction of benzene
alkylation
53
a hydrogen atom on a benzene ring
can be replaced by bromine or chlorine.
halogenation
54
in alkyl halides answer the foll. question
aka.
MP, BP ,solubility, type of compound, shelf, in vivo, common reactions
halogenated HC or halogenated alkenes, MP and BP depends on the size of alkyl group and halogen atom, lipid soluble, stable in shelf , not readily metabolized, nucleophilic reaction and dehalogenation
55
an organic compound in which an -OH group is bonded to a saturated carbon
atom.
alcohol
56
contain both a polar and a non polar character.
alcohol
57
alcohol chemical reaction in vivo
sulfation, oxidation, glucoronidation
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if oxidize primary alcohol
aldehydes wil be carboxylic acids
59
if oxidize 2ndary alochol
wil be ketone
60
most common reaction of alcohol
dehydration, oxidation , halogenation and combustion
61
three ways alcohol leaves the the body
kidney, lungs, liver
62
in liver chemically breaks down remaining alcohol to_______
acetic acid
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