1WBF(whole body fluid) compose of?
intracellular fluids and intracellular fluids
23 factors affecting drug distribution
membrane physiology
transport mechanism
GI physiology
32 organs that is low in perfusion
fat and bone
4volume of distribution is compose of
amount of drug in the body/ plasma concentration
5characteristics of GIT in GI physiology
Ph, Blood supply, GET and motility , membrane surface area
6factors affecting rate of distribution give 4
membrane permeability, capillary wall structure , drugs pka and blood ph, blood perfusion
72 parameters of drug distribution
volume distribution and protein binding
8greatest total blood flow organs
muscle, liver ,kidney, brain
9highest perfusion rate
brain,liver, kidney heart
10give 4 extent of distribution
ph-pka, tissue localization , lipid solubility, plasma protein binding