m3

t is a chemical reaction that occur in the body to
maintain life.

Breaks down organic matter

It uses energy to build up or
construct components of cells
such a proteins and nucleic
acids.

DRUG METABOLISM aka

Their pharmacologically active parent
compounds become detoxicated.

in Inactive Metabolites Hydrolysis of procaine to paminobenzoic acid and diethylamine results in

in Inactive Metabolites Oxidation of 6-mercaptopurine to 6-
mercatopuric acid results in

Retain the pharmacologic activity of
their parent compounds to a greater
or lesser degree

what is the chemical reaction of procaine

what is the chemical reaction of 6 mercaptopurine

what is the chemical reaction of imipramine

what is the chemical reaction of acetohexamide

what is the chemical reaction of codeine

what is the chemical reaction of antidepressant iproniazid

what is the chemical reaction of vitamin a

what is the chemical reaction of vitamin retinoic acid

what is the chemical reaction of enalapril

what is the chemical reaction of sulindac

what is the chemical reaction of antiparkinsonian Levodopa

what is the therapeutic and product of procaine

what is the therapeutic and product of 6 mecaptopurine

what is the therapeutic and product of imipramine

what is the therapeutic and product of acetohexamide

what is the therapeutic and product of iproniazifd

what is the therapeutic and product of vitamin retinoic acid

what is the therapeutic and product of enalapril

what is the therapeutic and product of sulindac

what is the therapeutic and product of antiparkinsonian Levodopa

Develop different activity from that
of their parent compound

Pharmacologically inactive parent
compounds are converted to active
species within the body.

parent compound aka

in oxidation Majority occurs in the _____

6 mammalian families are involved in the ______ and bile _____ metabolism: and innumerate the 6 mammalian families

4 mammalian families are involved in _______ or _____: and innumerate the 4 mamalian

phase 1 in oxidation,it is Catalyzed by __________ bound to smooth ER of the liver and require both _______ and a _______

Enzyme responsible for transferring an Oxygen atom
to the substrate is called

Plays a vital role in oxidation of lipophilic xenobiotics

Metabolizes almost unlimited
number of diverse substrates by
a
variety
of
oxidative
transformation

CYTOCHROME P-450 is located in

Bacteria in the GIT are involved in the ______ and ______
reductions.

To create more polar functional groups that can be
eliminated in the urine

Addition of water across a bond resulting a more
polar metabolites.

nonspecific and catalyze de-esterification, hydrolyzing
nonpolar to 2 polar, more water soluble compounds;
alcohol & aci; prodrugs into active forms

amides into amines and acids (deamination), occurs in
the liver

what are the common endogenous ?

Most conjugates are very polar resulting in __________