151-160

Soma

muscle relaxant

tablets: 250 and 350 mg

acute musculoskeletal conditions

unknown
may work centrally in spinal cord or descending reticular formation to produce muscle relaxation

acute intermittent porphyria
caution in liver or renal impairment
rare idiosyncratic reactions (weakness, dizziness, vision loss, euphoria, confusion)

drowsiness
dizziness
headache
nausea, vomiting, diarrhea, constipation

may take with meals if GI upset
may cause drowsiness
if dose missed, skip and return to schedule

Mevacor

antihyperlipidemic

tablets: 10, 20, 40 mg

hypercholesterolemia
atherosclerosis

inhibits HMG-CoA reductase, preventing cholesterol synthesis

pregnancy and lactation
liver disease
caution in liver dysfunction

constipation, dyspepsia, diarrhea, flatus, abdominal cramps, heartburn, nausea, headache, rash, myalgialurred vision

follow prescribed diet
take with meals
avoid overexposure to sunlight
discontinue if pregnant
report muscle pain
limit alcohol use
if missed, take asap, if within 12 hours of next dose, skip next dose and return to schedule

Plaquenil

tablets: 200mg

antimalarial, RA agent

malaria
lupus erythematosus
rheumatoid arthritis

unknown
may raise pH of parasitic components

do not use long term in children
caution in psoriasis, porphyria, pregnancy, and liver disease
may cause retinopathy long-term

headache
dizziness
nausea
visual disturbances
edema
weight loss
blood dyscrasias
nervousness
anorexia
abnormal skin pigmentation

take with food to decrease GI upset
watch for flu-like symptoms
if dose missed, take asap, but not if closer to next dose

Minocin, Dynacin, Solodyn ER

capsules, Minocin: 50, 75, 100 mg
tablets, Dynacin: 50, 75, 100 mg
ER tablets, Solodyn: 45, 55, 65, 80, 90, 105, 115, 135 mg
powder for injection: 100mg

bacterial infections
syphilis, gonorrhea, chlamydia
acne vulgaris

tetracycline antibiotic that prevents proteins synthesis by binding to 30S ribosomal subunits of bacteria

tetracycline antibiotic

children under 8
pregnancy and lactation
impaired renal function

dizziness
vertigo
nausea
emesis
diarrhea
discoloration of teeth
sore or darkened tongue
cramps
burning stomach
rare photosensitivity reactions

take on empty stomach with full glass of water
take with food or milk only if GI upset
complete full course of therapy
do not take antacids within 2 hours
if dose missed, take asap

mysoline

antiepileptic

tablets: 50, 250 mg
suspension: 250mg/5mL

control of epileptic seizures

unknown
metabolized into phenobarbital and phenylethylmalonamide
sensory cortex depression via inhibition of conduction in reticular formation at thalamus

hypersensitivity to barbiturates
porphyria
caution in pregnancy, elderly, impaired liver function
may increase suicidal thoughts

dizziness
ataxia
nausea
vomiting
drowsiness
impotency

may cause dizziness
avoid alcohol
if dose missed, take asap, unless closer to next dose

Lovaza

antihyperlipidemic

liquid-filled gel capsule: 1g with 900mg

hypertriglyceridemia

unknown
may inhibit acyl CoA -> decreased lipogenesis and increased lipase activity
may reduce triglyceride synthesis

caution in fish allergy
try lifestyle changes first (and discontinue estrogen therapy, thiazide diuretics, and beta blockers)

belching
infection
flu-like symptoms
dyspepsia
taste perversion
back pain
rash
angina

take with meals
closely follow prescribed diet
if dose missed, skip and return to schedule

Carafate

anti ulcer agent

tablets: 1g
suspension: 1g/10mL

treatment of duodenal ulcer

forms an ulcer-adherent complex that covers the ulcer site and protects from further damage

caution in chronic renal failure due to possible absorption of small amounts of aluminum

constipation

take on empty stomach
do not take antacids within 30 minutes
store away from heat, moisture, and sunlight
if dose is missed, skip
do not take within 2 hours of other meds

Lanoxin
Digitek

cardiac glycoside; antiarrhythmic

tablets: 0.125, 0.25 mg
elixir (pediatric): 0.05mg/1mL
injection: 0.1, 0.25 mg/mL

heart failure
atrial fibrillation
atrial flutter
paroxysmal atrial tachycardia

inhibits Na/K ATPase pump, leading to increase in Na inside cell, Ca 2+ enters cell, increasing force and velocity of systolic contractions, slowing of heart rate, and decreased conduction velocity through AV node

ventricular fibrillation
caution in pregnancy, nursing, severe carditis, heart failure and acute glomerulonephritis, renal impairment, hypokalemia, hypomagnesemia, hypercalcemia, acute MI, pulmonary disease, incomplete AV block, sinus node defects

anorexia
n/v
gynecomastia
blurred vision
headache
bradycardia

do not discontinue
do not take OTC cough/cold, antacids, laxatives, or antidiarrheals
if dose missed, take asap, unless closer to next dose

Nizoral

antifungal

tablets: 200mg
cream: 2%
shampoo: 2%

systemic fungal infections
seborrheic dermatitis
reduction of scaling due to dandruff

inhibits synthesis of ergosterol, the main sterol of fungal cell membranes

do not use for fungal meningitis
hepatotoxicity possible
caution in pregnancy and lactation

n/v
topical irritation

do not take with antacids
take tablets with food or acidic beverage
may cause drowsiness or dizziness
watch for signs of liver dysfunction
can remove curl from hair
if dose missed, take asap unless closer to next dose

motrin

tablets: 400, 600, 800 mg
OTC: 200mg; liquid and chewable

NSAID

mild to moderate pain
dysmenorrhea
rheumatoid arthritis
osteoarthritis
juvenile arthritis

inhibits COX, leading to decreased prostaglandin synthesis

not recommended in pregnancy
caution in renal and liver impairment, hypertension, fluid retention, heart failure, bleeding disorders, peptic ulcer
GI bleeding and blood clots possible

indigestion
constipation
abdominal cramps
flatulence
dizziness
rash
pruritus
heartburn
nausea
diarrhea
tinnitus
anorexia

up to 2 weeks before improvement seen
take with food or milk if GI upset
use with alcohol will increase ulcers
watch for rash
if dose missed, take asap, unless closer to next dose

250-350mg tid and at bedtime

muscle relaxant

C

20mg qd with evening meal

LFT, Lipid Panel

X

400-600mg qd

annual eye exam

200mg initially with 100mg every 12h

tetracycline antibiotic

D

250mg 3-4 times daily

D

1200-3200mg in 3-4 divided doses

LFT, RFT

4g in 1-2 doses with meals

lipid panel

C

1g qid on empty stomach

B

0.125-0.5mg qd

serum digoxin

C

LFT

apply bid for 4 weeks or until clinical clearing

C