1time period indication for biopsy
2 weeks after therapy/tx
2clinical indication for biopsy - conditions
leukoplakia, erythroplakia, persistent/widespread ulcerations
3clinical indications for biopsy - symptom changes
persistent color change/new growth
4clinical indication for biopsy - radiographic
inflammatory PA lesions, intrabony cysts/tumors
5clinical characteristics of lesions
color
consistency
architecture
distribution
pain
6macule
flat focal area, color blue/ brown/ black, no elevate/depress, 1cm>
7macules from foreign objects
amalgam/ graphite tattoos
8patch
flat lesion larger than macule, diff by color/texture, no elev/dep
9drugs that induce pigmentation (patch)
hormone replacement therapy, birth control
10life-threatening oral patch
oral melanoma
11differential dx of macules/patches: solitary
amalgam/etc tattoos
oral melanotic macule
blue nevus
melanoma
12differential dx of macules/patches: generalized
physiologic or drug induced pigmentation
13differential dx of macules/patches: multiple
peutz-jeghers syndrome
addison's disease
14macule/patch biopsy technique
ellipse/punch
small = entire
large = transition
15plaque
slight elev lesion
flat surface
can be 1cm+
16what category does oral cancer belong in
plaque! lateral tongue common
17differential dx of plaques: solitary
hyperkeratosis/frictional keratosis
epith dysplasia (oral cancer)
18differential dx of plaques: generalized (bilateral)
linea alba
tobacco pouch keratosis
leukoplakia
19plaque biopsy technique
transition zone
if too large, central area or two sites
20papillary/polyp
small exophytic growths
cauliflower/ round mass
thin stalk
21differential dx of p.p.: solitary
squamous papilloma
verruca vulgaris
squamous cell carcinoma
22differential dx of p.p.: gen bilat
inflam papillary hyperplasia
condyloma acuminatum (STI)
heck's disease
23p.p biopsy technique
scissors > snip
avoid forcep squeeze artifact
24erosion
depressed superficial lesion, partial mucosa loss
vesicle/ bulla rupture or irritant
ill defined border
25ulcer
well circumscribed
GO BEYOND BASAL LAYER
involves underlying CT (erosion don't)
26differential dx ulcer/erosion: solitary
traumatic/aphthous ulcer
squamous cell carcinoma
27differential dx ulcer/erosion: gen
herpetic lesions
mucosal burns
erosive lichen planus
28ulcer/erosion biopsy tech
near transition zone
need good clinical hx
29when would you biopsy center of an ulcer
when it is mycosis, looks black; indicates fungal inf and necrosis with fungal elements in it
30clinical features of soft tissue lesions
various origin
usually solitary, slow grow
nontender and asympto unless trauma
moves teeth (not loosen)
most benign
31papule
bubble shaped projection/elevation
caused by proliferation of soft tissue
<1cm
32differential dx papule: solitary
fibroma
pyogenic granuloma
33differential dx papule: gen bilat
fordyce granules (hair)
neurofibromatosis
cowden syndrome
34papule biopsy tech
avoid tearing
usually excise entire lesion
35what do multiple papules indicate
systemic etiology or syndrome (neurofibromatosis)
36nodule
raised dome shape
1cm+
can palpate
sessile
37differential dx nodule: solitary
fibroma
lower lip mucocele
pyogenic granuloma
ossifying fibroma
salivary gland tumor
squamous cell carcinoma
38differential dx nodule: gen bilat
neurofibromatosis
39nodule biopsy tech
excise entire lesion
if large, sample adequately
40petechiae
tiny round brown-red spots
bleeding under mucosa
41purpura
red-purple rash spots
bleeding from small bv
42ecchymosis
discoloration of subcutaneous from bleeding
1cm+
43hematoma
blood collecting in CT
45hemangioma
BV proliferation
46what is diascopy
blanching an area by pressing against it, seeing if vascular vs salivary
if vascular it will blanch blood
47diff dx vascular: solitary
hemangioma
epith dysplasia
pyogenic granuloma
submucosal hemorrhage
48diff dx vascular: gen bilat
URI
leukemia
49vascular lesions biopsy tech
biopsy pearls (entire lesion)
50vesicle, bullae, pustule characteristics
fluid/pus below epith
ulcer if ruptured
difficult biopsy
51vesicles
small fluid filled cyst/vacuoles
sub or intra epith
transient if intraoral
less than 5mm
52diff dx vesicles
herpes
superficial mucocele
53bullae
fluid filled sac
5mm+
transient if intraoral
54diff dx bullae
bullous pemphigoid
pemphigus vulgaris
55pustule
small circumscribed elevated collection of pus
usually <5mm
56diff dx pustule
chrons disease
57vesicle/ bullae/pustule biopsy tech
peri-lesional areas to avoid surface floating away
avoid gingiva
58multilocular vs unilocular
multi: multiple bubbles (Honeycomb)
uni: one big bubble
59how to define architecture of bone lesion
uni/multilocular
60how to define cortication of bone lesion
well-defined or thick corticated
ill defined or wide zone of transition
61first characteristic considered for bone lesions
radiopaque, radiolucent, mixed luc/paq
62effect of bone lesions on surrounding structures
expansion
displacement or resorption of hard tissues
63how to distinguish between granuloma and radicular cyst
INDISTINGUISHABLE
64residual cyst vs radicular cyst
residual cyst has SCLEROTIC BORDER @ apical area of missing tooth
65how to distinguish incisive canal cyst
heart shaped
between roots of max centrals
6mm+
66how to distinguish lateral periodontal cyst
usually PM-canine region
lucency interradicular to 2 adj teeth
67what deficiency is in 2/3M region inferior to mandibular canal (below IAN)
stafne bone defect
68stafne bone defect primarily affect
males
69is traumatic bone cyst true cyst
pseudocyst because it has no epithelial lining
70unilocular radiolucencies
traumatic bone cyst
stafne bone defect
lat perio cyst
incisive canal cyst
residual cyst
dentigerous cyst
radicular cyst
odontogenic keratocyst
71dx: multilocular soap bubble/honeycomb radioluc
ameloblastoma
central giant cell granuloma
72most common odontogenic tumor
ameloblastoma
73**one of few lesions in the ant mand crossing midline
giant cell granuloma
74genetic condition for posterior mand giant cell granuloma
cherubism
75biopsy tech for radiolucent region
aspirate prior, assess, remove
76diff dx solitary: unilocular bone lesions
radicular cyst
dentigerous cyst
odontogenic keratocyst
stafne bone defect
77diff dx : multilocular bone lesions
ameloblastoma
central giant cell granuloma
cherubism
78diff dx gen bilat: bone lesions
nevoid basal cell carsinoma (Gorlins)
cherubism
79intrabony lesions biopsy tech
small: complete enucleate
some cystic need ostectomy
80chronic osteomyelitis
immune compromise/hypovascular
subacute: ill defined lucent
chronic: lucent and opaque
81mixed radiolucent/ radiopaque lesions
chronic osteomyelitis
focal/periapical/florid cemento-osseous dysplasia
ossifying fibroma
82what tx is not necessary for periapical cemento osseous dysplasia
RCT
83periapical cemento-osseous dysplasia more commonly affects
middle aged black women
84radiopaque lesions
tori
root tips
condensing osteitis
focal idiopathic osteosclerosis
compound/complex odontoma
fibrous dysplasia
osteosarcoma
85biopsy tech for intrabony radiopaque lesions
large sample
surgical findings are impt (demarcated, easy remove, etc)
86why do condensing osteitis form
host bone rxn to wall off inflam products
8790% of these radiopaque lesions are at the mandibular pm-m region
focal idiopathic osteosclerosis
88how to distinguish focal idiopathic osteosclerosis
no radiolucent rim
89how to distinguish compound odontoma
collection of mini teeth in fibrous sac
90what radiopaque bone lesion impedes eruption path of teeth
complex odontoma