diff dx

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1
time period indication for biopsy
2 weeks after therapy/tx
2
clinical indication for biopsy - conditions
leukoplakia, erythroplakia, persistent/widespread ulcerations
3
clinical indications for biopsy - symptom changes
persistent color change/new growth
4
clinical indication for biopsy - radiographic
inflammatory PA lesions, intrabony cysts/tumors
5
clinical characteristics of lesions
color
consistency
architecture
distribution
pain
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macule
flat focal area, color blue/ brown/ black, no elevate/depress, 1cm>
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macules from foreign objects
amalgam/ graphite tattoos
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patch
flat lesion larger than macule, diff by color/texture, no elev/dep
9
drugs that induce pigmentation (patch)
hormone replacement therapy, birth control
10
life-threatening oral patch
oral melanoma
11
differential dx of macules/patches: solitary
amalgam/etc tattoos
oral melanotic macule
blue nevus
melanoma
12
differential dx of macules/patches: generalized
physiologic or drug induced pigmentation
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differential dx of macules/patches: multiple
peutz-jeghers syndrome
addison's disease
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macule/patch biopsy technique
ellipse/punch
small = entire
large = transition
15
plaque
slight elev lesion
flat surface
can be 1cm+
16
what category does oral cancer belong in
plaque! lateral tongue common
17
differential dx of plaques: solitary
hyperkeratosis/frictional keratosis
epith dysplasia (oral cancer)
18
differential dx of plaques: generalized (bilateral)
linea alba
tobacco pouch keratosis
leukoplakia
19
plaque biopsy technique
transition zone
if too large, central area or two sites
20
papillary/polyp
small exophytic growths
cauliflower/ round mass
thin stalk
21
differential dx of p.p.: solitary
squamous papilloma
verruca vulgaris
squamous cell carcinoma
22
differential dx of p.p.: gen bilat
inflam papillary hyperplasia
condyloma acuminatum (STI)
heck's disease
23
p.p biopsy technique
scissors > snip
avoid forcep squeeze artifact
24
erosion
depressed superficial lesion, partial mucosa loss

vesicle/ bulla rupture or irritant

ill defined border
25
ulcer
well circumscribed

GO BEYOND BASAL LAYER

involves underlying CT (erosion don't)
26
differential dx ulcer/erosion: solitary
traumatic/aphthous ulcer

squamous cell carcinoma
27
differential dx ulcer/erosion: gen
herpetic lesions
mucosal burns
erosive lichen planus
28
ulcer/erosion biopsy tech
near transition zone
need good clinical hx
29
when would you biopsy center of an ulcer
when it is mycosis, looks black; indicates fungal inf and necrosis with fungal elements in it
30
clinical features of soft tissue lesions
various origin

usually solitary, slow grow

nontender and asympto unless trauma

moves teeth (not loosen)

most benign
31
papule
bubble shaped projection/elevation

caused by proliferation of soft tissue

<1cm
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differential dx papule: solitary
fibroma
pyogenic granuloma
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differential dx papule: gen bilat
fordyce granules (hair)
neurofibromatosis
cowden syndrome
34
papule biopsy tech
avoid tearing
usually excise entire lesion
35
what do multiple papules indicate
systemic etiology or syndrome (neurofibromatosis)
36
nodule
raised dome shape

1cm+

can palpate

sessile
37
differential dx nodule: solitary
fibroma
lower lip mucocele
pyogenic granuloma
ossifying fibroma
salivary gland tumor
squamous cell carcinoma
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differential dx nodule: gen bilat
neurofibromatosis
39
nodule biopsy tech
excise entire lesion

if large, sample adequately
40
petechiae
tiny round brown-red spots

bleeding under mucosa
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purpura
red-purple rash spots

bleeding from small bv
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ecchymosis
discoloration of subcutaneous from bleeding
1cm+
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hematoma
blood collecting in CT
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varix
dilated vessel
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hemangioma
BV proliferation
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what is diascopy
blanching an area by pressing against it, seeing if vascular vs salivary

if vascular it will blanch blood
47
diff dx vascular: solitary
hemangioma
epith dysplasia
pyogenic granuloma
submucosal hemorrhage
48
diff dx vascular: gen bilat
URI
leukemia
49
vascular lesions biopsy tech
biopsy pearls (entire lesion)
50
vesicle, bullae, pustule characteristics
fluid/pus below epith

ulcer if ruptured

difficult biopsy
51
vesicles
small fluid filled cyst/vacuoles

sub or intra epith

transient if intraoral

less than 5mm
52
diff dx vesicles
herpes
superficial mucocele
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bullae
fluid filled sac

5mm+

transient if intraoral
54
diff dx bullae
bullous pemphigoid
pemphigus vulgaris
55
pustule
small circumscribed elevated collection of pus

usually <5mm
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diff dx pustule
chrons disease
57
vesicle/ bullae/pustule biopsy tech
peri-lesional areas to avoid surface floating away

avoid gingiva
58
multilocular vs unilocular
multi: multiple bubbles (Honeycomb)

uni: one big bubble
59
how to define architecture of bone lesion
uni/multilocular
60
how to define cortication of bone lesion
well-defined or thick corticated

ill defined or wide zone of transition
61
first characteristic considered for bone lesions
radiopaque, radiolucent, mixed luc/paq
62
effect of bone lesions on surrounding structures
expansion

displacement or resorption of hard tissues
63
how to distinguish between granuloma and radicular cyst
INDISTINGUISHABLE
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residual cyst vs radicular cyst
residual cyst has SCLEROTIC BORDER @ apical area of missing tooth
65
how to distinguish incisive canal cyst
heart shaped

between roots of max centrals

6mm+
66
how to distinguish lateral periodontal cyst
usually PM-canine region
lucency interradicular to 2 adj teeth
67
what deficiency is in 2/3M region inferior to mandibular canal (below IAN)
stafne bone defect
68
stafne bone defect primarily affect
males
69
is traumatic bone cyst true cyst
pseudocyst because it has no epithelial lining
70
unilocular radiolucencies
traumatic bone cyst
stafne bone defect
lat perio cyst
incisive canal cyst
residual cyst
dentigerous cyst
radicular cyst
odontogenic keratocyst
71
dx: multilocular soap bubble/honeycomb radioluc
ameloblastoma
central giant cell granuloma
72
most common odontogenic tumor
ameloblastoma
73
**one of few lesions in the ant mand crossing midline
giant cell granuloma
74
genetic condition for posterior mand giant cell granuloma
cherubism
75
biopsy tech for radiolucent region
aspirate prior, assess, remove
76
diff dx solitary: unilocular bone lesions
radicular cyst
dentigerous cyst
odontogenic keratocyst
stafne bone defect
77
diff dx : multilocular bone lesions
ameloblastoma
central giant cell granuloma
cherubism
78
diff dx gen bilat: bone lesions
nevoid basal cell carsinoma (Gorlins)
cherubism
79
intrabony lesions biopsy tech
small: complete enucleate

some cystic need ostectomy
80
chronic osteomyelitis
immune compromise/hypovascular

subacute: ill defined lucent
chronic: lucent and opaque
81
mixed radiolucent/ radiopaque lesions
chronic osteomyelitis
focal/periapical/florid cemento-osseous dysplasia
ossifying fibroma
82
what tx is not necessary for periapical cemento osseous dysplasia
RCT
83
periapical cemento-osseous dysplasia more commonly affects
middle aged black women
84
radiopaque lesions
tori
root tips
condensing osteitis
focal idiopathic osteosclerosis
compound/complex odontoma
fibrous dysplasia
osteosarcoma
85
biopsy tech for intrabony radiopaque lesions
large sample
surgical findings are impt (demarcated, easy remove, etc)
86
why do condensing osteitis form
host bone rxn to wall off inflam products
87
90% of these radiopaque lesions are at the mandibular pm-m region
focal idiopathic osteosclerosis
88
how to distinguish focal idiopathic osteosclerosis
no radiolucent rim
89
how to distinguish compound odontoma
collection of mini teeth in fibrous sac
90
what radiopaque bone lesion impedes eruption path of teeth
complex odontoma
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