1temporal lobe
studying temporal lobe = studying memory
memory is in medial temporal lobe
2long term memory location
long term memory associated with amygdala and hippocampus
3patient HM
removal bilateral medial temporal lobe
including hippocampus and amygdala besides others
4consequences for patient HM
impossible to store and consolidate new information ( anterograde amnesia )
impaired in spatial and topographic learning and events that took place around him
able to learn new motor skills by repetition
long term memory pre
5operative events were intact ( time dependent amnesia )
short term memory was intact
6amnesia
= the lost of existing memories or the inability of forming new memories
7cauase of amnesia
it stems form an event or accident that causes memory loss
8types of amnesia
1. Anterorgade amnesia
2. Retrograde amnesia
9anterograde amnesia
inability to make new memories
10retrograde amnesia
loss of memory before the event
time dependent : more recent events more likley to be lost
11short term memory
sensory
motor
cognitive
12working memory
working memory is not always short term memory
13long term memory types
1. explicit
2. implicit
3. emotional
14explicit memory
conscious
1. episodic
2. semantic
15episodic memory
personal : what i had this morning for breakfast
16semantic memory
facts : who is the second priminister
17implicit memory
unconscious : skills , habits , priming , conditioning
18emotional memory
conscious and unconscious ) : attraction, avoidance fear
19learning episodic memory
new learning in general like learning for neurospychology
20regions for sematic memeory
includes frontal and temporal regions ( distinct form episodic )
more lateral temporal lobe in left hemisphere
more repetioiton = more lateralised
21episodic memory regions
hippocampus is essential ( medial temporal lobe )
after reading the same text over and over again → transported to lateral temporal cortex ( location of semantic memory )
22importance structures
in explicit memory the temporal lobe structures plays one of the most important roles
to remember : that medial thalamus plays a role as well
23most important structure inprocedual memory
the basal ganglia
24how we test implict memory
implicit memory can be seen in experiments such as mirror tests
patient HM was able to master a skill the more he was rehersing it
he could not remeber the task however he did it faster and faster each time
25emotional memory
amygdala is the most important part of the circuit
26**Prefrontal cortex in memory**
participates in autobiographical memory
there is a pattern of hemispheric asymmetry between memory encodic and retrieval
27HERA
**hemispheric encoding and retrieval asymmetry**
28left HERA
more encoding of semantic than retrieving it
more encoding of episodic than retrieving it
29right HERA
more retrieval of episodic memory
30other important areas
left oribitofrontal cortex active during memory encoding of words/series of words
these regions do not retrieve the information
right dorsal prefrontal cortex and posterioir parietal cortex in both hemispheres are activated in retrieval
31**Korsakoff syndrome**
esion : dorsomedial part thalamus + frontal
also called diecephalic amnesia
32cause of Karsokoff syndrome
prolonged excessive alcohol abuse , low vit B1 deficit
33symptoms
anterograde / retrograde amnesia
confabulations
coversation : little informative
lack of insight
apathy/ indiference
34Dorsal and ventral stream in STM
different short term areas take part in STM
cells that code spatial vision are located in area 8 (premotor cortex)
cells that code object recognition are located in area 9 and 46 of dlPFC >
35central executive ("slave systems ")
1. phonological loop ( verbal and auditory information )
2. visuospatial sketchpad (visual and spatial information )
36role of central executive
attentional controller (distributes attention across tasks )
coordination of complex cognitive operations ( e.g. 12 x 27)
37Kluver Bucy syndrome
cause ( bilateral anterioir temporal lobe lesion )
symptoms
visual agnosia
changes in dietary hbits ( eats everything )
reaction to every stimulus
hyperoral behaviour (puts everything in mouth )
loss of feaar
increase in auto erotic, homo eroticor eteroerotic activity