1what are the periods of development?
early development (fert-2wks)
embryonic period (3-8wks)
fetal period (9-end)
2what happens during the psriod of early development? (x5)
fertilization and implantation
proliferation
formation of trilaminar embryo
placenta is formed
determination of body axes
3what happens during the embryonic period?
organs and body parts form
4what is succeptable to birth defects in the fetal period?
brain, eyes, ears, teeth, pallette, external genitalia
5parental and materal strands
diploid
6one copy (either parental or maternal or a mix)
haploid
7what is the final product of spermatogenesis?
4 spermatids

8what is the final product of oogenesis
ovum and 3 polar bodies

9stem cells that can form sperm or eggs, unfertilized at this point
primordial germ cells
10where do the primordial germ cells travel to differentiate?

epiblast to yolk sac to genital ridge
11what forms in/around the genital ridge

gonads and kidneys
12what do the primordial germ cells becme when they enter the genital ridge
primitive sex cords
13what surrounds the primative sex cords if they are destined to become testes
sertoli cells
14what surrounds the primative sex cords if they are destined to become oocytes
follicular cells
15when do the primordial germ cells actovate in males
puberty
16what is the pathway to primordial germ cell activation in males
LH activates leydig cells that make testosterone that activates primordial germ cells
17what is the blue?

sertoli cells
18what is the orange?

sperm making cells
19what is the 3 at the center?

lumen
20sperm making pathway
spermatogonia via mitosis to primary spermatocyte to 2nd spermatocyte to spermatid
primary to spermatid is meiosis
21conversion of spermatids into mature sperm
spermiogenesis
22what does the process of spermiogenesis include
cytoplasm shed, condense nucleus, neck and tail formation, acrosome formed
23where does capacitation occur
vagina and uterus
24what does capacitation do?
prunes glyconalyx proteins on the sperm
25By week _________________ of development, a population of oogonia enter the first meiotic prophase and become dormant until ________________________
12; puberty
26oocyte and follicle cells together

ovarian follicle
27what secreted by the folicular cells prevents any further progression of the cell cycle
OM1
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31what specific primary cell type?

primordial
32primary? secondary? definitive?

primary
33specific primary folicle type

graafian
34The hypothalamus releases this to control levels of pituitary hormone and ovulation

GnRH
35when do LH and FSH spike causing an estradiol spike

ovulation
36what type of follicule

graafian
37what oocyte detaches into the atrium during ovulation
2ndary oocyte
38what is the summary of female egg production
oogonia via mitosis to primary oocyte to 2ndary oocyte to definitive oocyte (meiosis is 1st to definitive)
2nd oocyte made at ovulation
definitive oocyte made at fertilization
39what happens if there is implantation (corpus luteu)
secretes chorionic gonadotropic hormone (hCG); this keeps the corpus luteum (corpus luteum of pregnancy) producing progesterone (required for maintaining pregnancy) for about five months, after which the placenta produces progesterone
40Trisomy 21?
Down syndrome
41X0

turner syndrome
42XXY?
kleinfelters syndrome
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44what are the phases of fert
sperm penitrates corona radiata
sperm penitrates zona pellucida
fusion of sperm and oocyte membranes which completes the 2nd meiotic division of the oocyte
45what is the zona rxn
oocyte change zona pelucida rxn so more sperm cant enter
46what is the cortical reaction
oocyte change PM to prevent further sperm fertilization
47what are the zygote cells called in the first week of division
blastomeres
48what happens during compaction
increase surface area, making gap junctions, shifting nuclei towards the center
49blastocyst
what stage of division does the cell invade the wall of the uterus
50when does implantation occur
5.5-6 days
51what is an ectopic pregnancy
pregnancy occurs in the wrong spot
52implantation in the cervix
placenta previa
53detachedleeding of the uterus
placenta abruption
54placenta penitrates too deply into the uterine wall
placenta accreta
55placenta penitrates too deeply into the uterine muscle
polacenta increta
56placenta penitrates too deeply through the uterne wall into the organs
placenta percreta
57what develops from the embryoblast?
epiblast and hypoblast
58what does the embryoblast make
embryo
59what does the trophoblast make
placenta
60what tissues form from the trophoblast (cell types)
syncytiotrophoblast and cytotrophoblast
61what two spaces develop in the 2nd week
amnion and yolk sac
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65what is the asterix (cavity)?

amniotic cavity
66where does the amniotic fluid come from?
fetus and placenta
67too much amniotic fluid
polyhydraminos
68too little amniotic fluid
oligohydraminous
69these form from the hypoblast and line the primary yolk sac

Heuser membrane (line whole yolk sac), extraembryonic endoderm
70what are the layers of the extraembryonic mesoderm?

somatic, splanchnic
71this secretes HCG
syncytiotrophoblast
72what could increased HCG levels indicate?
Pregnancy
Ectopic pregnancy (typically in the low range)
Hydatidiform mole (typically very high)
Choriocarcinoma
Germ cell tumor (testes, ovaries)
Hepatoma
Lymphoma
73what could decreased HCG levels on repeated testing mean
**indicative of decreased viability of the placenta**
High risk of spontaneous abortion
Dead fetus
74these in the syncytiotrophoblast, fill with blood

trophoblastic lacunae
75what layers must materials initially cross tp resach mother to fetus
syncithiotrophoblast to cytotrophoblast tpo connective tissue to fetal blood vessels
76what tissues is the chorion composed of?

syncitiotrophoblast, cytotrophoblast, mesoderm
77the X genome develops ___________________ and the Y genome develops ____________
embryoblast tissue; placental tissue
78what are the propose mechanisms for molar pregnancy (x2)
1) empty egg fert with only sperm
2) 2 sperm fertilize an egg
79what are some key signs for molar pregnancy
Bleeding in the first half of pregnancy
Lower abdominal pain
Pre-eclampsia before 24 weeks’ gestation
Hyperemesis gravidarum
Uterus “large for dates” (only 50% of cases)
Absent fetal heart sounds, no fetal parts present
Expulsion of “grape-like” vesicles (hydropic villi)
80intellectual disability, congenital heart defects, low-set ears, and flexion of fingers and hands (Fig. 2.10). In addition, patients frequently show micrognathia, renal anomalies, syndactyly, and malformations of the skeletal system.
Trisomy 18
81intellectual disability, holoprosencephaly, congenital heart defects, deafness, cleft lip and palate, and eye defects, such as microphthalmia, anophthalmia, and coloboma; 90% die days after birth
trisomy 13
82only monosomy compatible with life. Even then, 98% of all fetuses with the syndrome are spontaneously aborted. The few that survive are unmistakably female in appearance (Fig. 2.12) and are characterized by the absence of ovaries (gonadal dysgenesis) and short stature. Other common associated abnormalities are webbed neck, lymphedema of the extremities, skeletal deformities, and a broad chest with widely spaced nipples.
Turner syndrome
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89what three layers form the third week
amnion, yolk sac, chotrion
90when does gastrulation occur?

day 16
91what is the stody of gastrulation

cells of epiblast divide and migrate under the primitive strek, hypoblast reoplaced with endoderm, mesoderm formed inbetween, epiblast replaced with ectoderm
92how does the notochord form?

invaginates from primitive pit and extends, fuses witj endoderm and becomes notochordal plate, detaches and forms notochord
93what are the functions of the notochord (x4)

1. directs CNS development
2. development of the vertebral column
3. anatomic midline
4. forms the nucleus pulposis
94what are the two types of embryonic folding?

longitudinal fold: head to tail
transverse fold: ectoderm fuses wth each other
95heart forms outside the heart due to improper folding

ectopic cordis
96heart is on the wrong side of the body due to a midline defect

dextrocardia
97everything forms on the ride side of the body (organs) due to midline defects
ody axis defects
situs inversus
98epithalial mesoderm benign tumor
angiomas
99epithelial mesoderm malignant tumor
sarcomas
100epithalial endoderm/ectoderm benign tumors
papillomas/adenomas
101epithalial endo/ecto malig tumors
carcinomas
102connective tissue benign tumotr
fibroma, lipoma, chondroma, osteoma
103connective toissue malig timor
sarcoma
104what do neural crest cells form
ganglia cells
105what happens weeks 9-12 dev
wk9: liver hematopoetic organ
post wk9: external genitals male/female
106wks 13-16 dev?
ossification evident
eyes movement and eyes face forward
107wks 17-20 dev
primary oocytes formed
testes descend
108wks 21-25 dev
surfacant secreted in lungs
109wks 26-29 lungs
lungs breath
CNS can control breath and body temp
spleen makes blood but bone marrow can now
110wks 35-38 fetal dev
final prep of cardio and resp tissus
111what uterine layers must you penitrate in amniocentesis

perimetrium, myometrium, endometrium, chorion, amnion
112what is the pathway of somite development

paraxial mesoderm to somitomeres to somites
113what do somites differentiate into? (x2)

sclerotomes and dermomyotomes
114process where sclerotome portion of each somite's caudal half grows and fuses with the cranial half of the adjacent sclerotome

resegmentation
115the cranial portion of the first cervical sclerotome helps to form the ______________

occipital bone
116the intervertebral discs forms from these (x2)

notochord and sclerotomes
117the dermomyotome splits and becomes (x2)

dermatome and myotome
118muscles of the head are formed from
somitomeres
119muscles of the limbs are formed by
somites
120form Muscles of the back, shoulder girdle, and intercostal muscles

primaxial muscle cells
121form body wall, infrahyoid, and limb muscles

abaxial muscle cells
122what does the ventral ramus inivate

abdominal wall muscles and lumbs
123what is the most likely diagnosis?

poland anomaly
124if the cranial portion of the neuropore doesnt close

anancephally
125if the caudal portion of the neuropore doesnt clsoe

spina bifida
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129these cells differentiate into mesenchymal cells

microglia
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133what is the developmental sequence of nerves
1) GSE [control to muscles]
2) GVE [the outgoing part of the autonomic nervous system; only at certain levels!]
3) Sensory [returning information from skin, muscles, etc]
134what do neural crest cells give rise to specifically (5)
DRG, sympathetic chain, suprarenal g., prevertebral g., enteric ganglia
135neural tube doesnt close and neural tissue is sealed out of spinal column and not covered
spina bifida with meningocele
136neural tube doesnt close and neural tissue is sealed out of spinal column and is covered
spina bifida with myeloschisis
137occur during organogenesis and result in abnormal strcture

malformations
138results from external influences that cause alterations of completely formed structures or organs

disruptions
139abnornal structure resulting from mechanocal forces (congenital abnormality)

deformations
140abnormal organization of cells into tissue (congenital abnormality)

dysplasia
141absence of organ
agenesis
142cells to form an organ never formed (migrating cells)
aplasia
143anomalies occuring tofether without determined cause
association
144absence of opening or lumen
atresia
145overgrowth of an organ
hyperplasia
146underdevelopment of an organ
hypoplasia
147functions to stimulate the development of ovarian follicles and production of estrogen
FSH
148serves as a trigger for ovulation and stimulates the production of progesterone
LH
149secreted by the trophoblast and appears in materna;l blood 24-48hrs after fertilization, can be used for pregnancy tests during the first 10 days
Early pregnancy factor
150masses of endodernally derived tissue commonly associateds with the spinal cprd; derived from neurenteric canal where ectoderm and endoderm are closely associated

neurenteric cysts
151results from the innapropriate death of midline cells, causes a deficiencyt of midline head structures
holoprosencephally
152a neurological condition where the spinal cord is abnormally attached to surrounding tissues, limiting its movement and causing neurological problems
tethered cord syndrome
153vascular derivatives of the mesoderm
hemangioblasts: give rise to blood vessels
hematopoietic stem cells: give rise to blood cell precursors