anatomy & physiology I - biochem ---> digestive system

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1
Digestive System: Oral Cavity
Mechanical and chemical digestion.
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Digestive System: Esophagus
Transfers bolus via peristalsis.
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Digestive System: Stomach
Performs mechanical and chemical digestion.
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Stomach: Rugae
Folds in the stomach lining that allow for expansion.
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Stomach: Chief Cells
Secrete pepsinogen, which becomes pepsin to digest proteins.
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Stomach: Mucous Cells
Produce mucin to protect the stomach lining.
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Stomach: Parietal Cells
Secrete hydrochloric acid (HCl) to aid digestion.
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GERD
Gastroesophageal reflux disease, causing acid reflux; treated with PPIs, H2 antagonists, or surgeries like fundoplication or LINX.
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Small Intestine Regions
Duodenum, jejunum, and ileum.
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Small Intestine: Duodenum
The first section of the small intestine where most chemical digestion occurs.
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Small Intestine: Jejunum
The middle section of the small intestine where the majority of nutrient absorption takes place.
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Small Intestine: Ileum
The final section of the small intestine, primarily involved in absorbing vitamin B12 and bile salts.
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Small Intestine: Plicae Circulares
Folds that increase surface area for absorption.
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Small Intestine: Villi
Small finger-like projections that enhance nutrient absorption.
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Small Intestine: Enterocytes
Cells in villi responsible for nutrient absorption.
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Small Intestine: Brush Border Enzymes
Enzymes on the microvilli that aid in the final digestion of nutrients.
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Absorption into Capillaries
Monosaccharides, amino acids, and small polar molecules.
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Absorption into Lacteals
Triglycerides and cholesterol in the form of chylomicrons.
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Colon Function
Reabsorbs water and forms solid waste.
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Histology of the Alimentary Canal: Mucosa
The innermost layer containing epithelium, lamina propria, and muscularis mucosa.
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Histology of the Alimentary Canal: Submucosa
Contains blood vessels, nerves, and lymphatics.
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Histology of the Alimentary Canal: Muscularis Externa
Performs peristalsis and churning.
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Serosa vs. Adventitia
Serosa has an epithelial layer; adventitia does not.
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Liver Function
Synthesizes bile to emulsify fats; regulates blood sugar via glycogenesis and glycogenolysis.
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Gallbladder Function
Stores and releases bile to the duodenum.
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Pancreas: Exocrine Function
Secretes digestive enzymes like lipase, amylase, and trypsin.
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Homeostasis: Negative Feedback
A process that reduces deviations from a set point (e.g., blood glucose regulation).
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Homeostasis: Positive Feedback
A process that amplifies a response (e.g., blood clotting).
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Macromolecules: Carbohydrates
Provide energy; monomer = monosaccharide (e.g., glucose).
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Macromolecules: Lipids
Store long-term energy; include triglycerides, phospholipids, and steroids.
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Macromolecules: Proteins
Composed of amino acid monomers; function depends on folding and structure.
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Macromolecules: Nucleic Acids
Store genetic information; monomer = nucleotide; polymers = DNA, RNA.
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Cell Membranes: Phospholipid Bilayer
Provides structure and selective permeability for the cell.
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Cell Membranes: Cholesterol
A steroid that stabilizes membrane fluidity.
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Endomembrane System Components
Nucleus, Rough ER, Smooth ER, Golgi body, vesicles, and ribosomes.
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Membrane Transport: Simple Diffusion
Movement of molecules from high to low concentration without energy or proteins.
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Membrane Transport: Active Transport
Movement of molecules against a gradient using energy (ATP).
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Membrane Transport: Endocytosis
Cell engulfs materials using vesicles.
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Tissue Types: Epithelial
Lines and covers surfaces; involved in protection, secretion, and absorption.
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Tissue Types: Muscle
Specialized for contraction (skeletal, smooth, cardiac).
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Tissue Types: Connective
Supports other tissues; includes bone, blood, cartilage, and adipose.
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Tissue Types: Nervous
Responsible for communication and processing information.
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Water Properties in Physiology
Polarity and hydrogen bonding make water essential for life processes.
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Hydrogen Bonds
Weak intermolecular attractions between polar molecules.
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Regional Prefixes: Cardio-
Refers to the heart.
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Regional Prefixes: Gastro-
Refers to the stomach or digestive system.
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Regional Prefixes: Histo-
Refers to tissues.
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General Prefixes: Endo-
Means "within" or "inside."
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General Prefixes: Epi-
Means "on" or "above."
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General Prefixes: Intra-
Means "within" or "inside."
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Directional Terms: Superior/Inferior
Superior means "above"; inferior means "below."
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Directional Terms: Medial/Lateral
Medial means "toward the midline"; lateral means "away from the midline."
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Directional Terms: Proximal/Distal
Proximal means "closer to the point of attachment"; distal means "farther from the point of attachment."
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Colon: Ascending
The first section of the colon; reabsorbs water and moves waste upward on the right side of the abdomen.
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Colon: Transverse
The middle section of the colon; runs horizontally across the abdomen to continue water reabsorption.
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Colon: Descending
The section of the colon that moves waste downward on the left side of the abdomen.
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Colon: Sigmoid
The final S-shaped section of the colon; stores solid waste before it moves to the rectum.
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