Chapter 11: Eukaryotic Microbes and Invertebrate Parasites

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1
What are Protists?
microscopic (ussually single celled) eukarytoes, not plants, animals, or "higher fungi"
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What are protozoa?
*animal-like protists
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What are algae?
simple autotrophic (photosynthetic protists)
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What are fungi?
*heterotrophic organisms, contain chitin in cell wall
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What are two types of mutlicelluar protists?
*Arthropods
*Worms (parasites)
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Structure of molds?
*multi-cellular filamentous structures (hyphae=branch like) contains various terminal spores (buds at the end)
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How does yeast grow?
*grow as single cells with buds
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Structure of mushrooms:
*fruiting bodies and reproductive structures
-can be dimorphic
*aerobic (need O2) or facultatively anaerobic (doesn't prefer specific amounts of oxygen)
*chemoheterotrophic (dervies energy from chemicals, must consume other organisms to get this)
*most are decomposers (saprophytic)
*can be symbionts or parasites
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What are saprophytic organims?
*a plant, fungus, or microorganism that lives on dead or decaying organic matter.
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Term for visible mass of hyphae?
*mycelium
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In fungi, how do tips of hyphae grow?
*grow rapidly in direction of food source, spores reside in septa between cells (allowing movement along hyphae)
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What comprises cell wall of fungi?
*chitin
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Simple description of yeast?
*single celled eukaryotes that undergo asymmetric division
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True or false, Yeast can be diploid or haploid.
True, it depends on the cell cycle
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Name for bakers yeast?
*Saccharomyes cerevisiae
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How does fungi reproduce?
*has sexual and asexual stages of reproduction
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Describe mycorrhizas symbiotic relationship with fungi?
"fungus roots"
*fungus facilitates water and nutrient uptake in the plant
*plant provides food and nutrients created by photosynthesis to the fungus.
*fungus supplies nitrogen and phosphorus through breakdown of organic material in soil
-plant provides organic compounds
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What are lichens?
type of bacteria that has a symbiotic relationship with alga or cyanobacterium (photosynthetic)
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What is the relationship between lichens and photosynthetic member?
*fungus protects, absorbs water and minerals
*photosynthetic member provides organic nutrients
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Name for fungal diseases?
*myocoses
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What technology allows us to study communities of fungi (evaluate their symbiotic relationships?
*metagenomics
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Systemic mycoses are
deep within the body
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Subcutaneous mycoses are
beneath the skin
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Cutaneous mycoses affect
hair, skin, nails
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Superficial mycoses affect
localized ares... ex) hair shafts
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Opportunistic mycoses are caused by? Give an example
*caused by normal microbiota
*ex) candidiasis
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What are the four main types of fungal diseases?
*mycoses (systemic, subcutaneous, cutaneous, superficial, opportunistic)
*hypersensitivity reactions
*intoxication
*organisms specific infections
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What causes "intoxication" fungal disease?
*aflatoxins
*ergot toxins
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What are three organism specific fungal diseases we learned about?
*candidiasis
*histoplasmosis
*aspergillosis
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CO of Candidiasis? simple characteristics
*candida albicans (or C. tropicalis)
*dimorphic fungus (apart of normal flora)
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Classification of Candidiasis?
fungal infection
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POI of candidiasis?
*mucous membranes of mouth, intestional tract, genitourinary tract, and skin
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MOT of Candidiasis?
*sexually transmitted (direct contact)
*common constituent of normal flora
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Reservoir of Candidiasis?
humans
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What is histoplasmosis infection?
*respiratory (fungal) infection
*fungus grows in dimorphic ways (can produce abundant spores)
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CO of histoplasmosis?
*histoplasma capsulatum (dimorphic fungus)
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Where is histoplasmosis typically found? How is it transmitted?
*found in enclosed caves with bat poop and water
*transmitted by airborne conidia from soil
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Dx of Histoplasmosis?
*culturing fungus
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Tx for Histoplasmosis?
*amphotericin B
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What are algae?
*simple photosynthetic eukaryotes that lack organized vascular system and complex reproductive structures
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What unique things do Algae contain?
*chlorophyll (other pigements) that absorb radient energy
*rigid cell walls (made mostly of cellulose)
*some have flagella
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Where are algae found?
in aquatic environments
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What are dinoflagellates?
*one celled aquatic organisms that have two flagella
*capable of producing neurotoxins
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What neurotoxins do dinoflagellates produce? Mechanism of action?
*Saxitoxin
*Brevetoxin
they bind to ion channels and lead to paralysis
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Paralytic shellfish poisoning can be caused by ...
dinoflagellates (type of algae)
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what are protozoa? characteristics?
*single celled, eukaryotic organism (belongs to group of protists)
*motile
*some form cysts
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What are the four stages of protozoa life cycle?
*Trophozoite
*Schizogony
*Conjugation
*Cysts
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Describe Trophozoite life stage of Protozoa:
*vegetative state (growing not dividing, adolescents)
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Describe Schizogony life stage of Protozoa:
*division stage
*asexual repro by fissionudding
*remember it undergoes multiple rounds of nuclear division before cytokinesis
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Describe Conjugation life stage of Protozoa:
*sexual reproduction
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Describe Cysts life stage of Protozoa:
*dormant stage
*encased in protective chitin cell wall (resistant to digestion)
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What type of Protozoa is transmitted through consumption of tissue contaminated with cysts?
*Amebae
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What amebae causes travelers diarrhea?
*Entamoeba histolytica
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What causes amebic dysentery?
*Intestinal Amebiasis
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Transmission and motility of Entamoeba histolytica?
*transmitted through: cyst contamination
*motile because of pseudopod extension
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What are three examples of protozoa than are pathogenic in water supplies? (they are Cl- resistant)
*Plasmodium
*Cryptosporidum
*Toxoplasma
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What are two rare Amebae infections? briefly describe
*Naegleria fowleri (brain eating amoeba) found in freshwater
*Acanthamoeba (corneal infection)
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What rare amebae infection causes corneal infection?
*acanthamoeba
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What rare amebae infection is brain eating?
Naegleria fowleri
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What are apicomplexa?
intracellular parasite, non-motile, with complex life cycles (multi host and stages)
have apical complex (allows it to gain entry into cells)
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What are three examples of apicomplexa intracellular parasites?
*Plasmodium (ex) P. falciparum causes malaria)
*Cryptosporidium- causes watery diarrhea (spores are cl resistant and transmitted in water)
*Toxoplasma gondii (causes toxoplasmosis)
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In which host does sexual reproduction of an microoransim occur? give an ex
*definitive host
*ex) Malaria- mosqitos are defintive host (replication does not equal= sexual repro)
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What is definitive host?
Where the micro organism reproduces sexually
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What is intermediate host?
*is what carnovoir consumes (contains cysts in flesh)
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How are cysts in intermediate hosts spread?
Definitive host (carnovoir) consumes the intermediate host and ellimats cysts in feces
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What is Toxoplasmosis? CO? transmission? crazy cat lady lol
CO: Toxoplasma gondii
impacts behavoir (neurological damage and behavoir modifications)
transmission: consumption of undercooked meat
*contact with cat feces
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What are flagellates?
micro organism with one or more flagella
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What are Euglenids?
type of flagellates (contains flagella and chloroplasts)
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What are Trypanosomes? ex of disease they cause
*vector-borne parasite
*obligate parasite
*can cause chagas disease
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What are metamonads?
*type of protozoa
*have no mitochondria
*have multiple flagella
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What are two types of metamonads?
*Giardia lamblia
*Trichomonas vaginalis
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What organsim caused the lesion in the army veteran? clue: fly
*Leishmania Donovani (type of protozoa)
*can never fully get rid of it
*those infected can't donate blood
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What causes African Trypanosomiasis (sleeping sickness)? vector?
*Trypanosoma brucei
*vector is tsetse fly (salivary glands)
100% lethal
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Why is African Trypanosomiasis difficult to ellimate from the body?
*undergoes changes of surface antigens (rapid) prevnets immune system from elliminating it
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What are helminths?
*parasitic worms that infect humans and other animals
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What are platyhelminthes?
*flatworms
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What are two classes of Platyhelminthes (flatworms)?
*cestodes (tapeworms)
*trematodes (flukes)
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Cestodes aka?
Tapeworms
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Trematodes aka?
Flukes
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What are two types of Helminths (parasitic worms)?
*Platyhelminthas (flatworms)
*Nematoda (roundworms)
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What are three ways Helmines (parasitic worms) progress through life?
*Monoecious (male and female reproductive systems in one animal)
*Dioecious (separate male and female)
*egg to --larvae to --cysterci to --adult
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What cycle of Helminths impact definitive hosts (they consume cysts in tissue)?
*adult parasitic worms
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What cycle of Helminths impact intermediate host? (where cysts form)
*intermediate host
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How can Helminths (parasitic worms) enter the body?
*burrow through the skin
*cysts in contaminated meat
*contaminated crayfish and snails
*fecal-oral transmission
*vector transmission (mosquitoes)
85
tapeworms often are found in what flesh?
*beef and pork
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What is scolex portion of the tapeworm (type of flatworm)? purpose?
*includes hooks and sucker
*holds worm in position, prevents it from being elliminated
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What are proglottidis in tapeworms?
*sexually reproductive segments of the adult worms
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What is cysticercosis?
*infection by larval stage of tapeworms
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What are Hydatid disease? What are hydatid cysts?
*parasitic infection caused by tapeworm
*hydatid cysts=large fluid filled bladders that can cause anaphylatic shock if they rupture
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Termatodes aka as Flukes are a type of ...
Platyhelminthes
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What is a type of blood fluke? give some details
Schistosmiasis: causes cullar damage in response to eggs lodging in tissues
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Flukes can impact?
blood, lungs, mucosa
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T or F, Nematodes are a type of Helminths (parasitic worm)?
T
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What organism causes trichinosis?
nematode (worm within a cyst)
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Pinworms are a type of
Nematode (parasitic worm)
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