MCB Lec 2

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1
What forces stabilize structures?
Covalent Bonds
Noncovalent bonds
2
What consists of non covalent bonds?
Hydrogen bonds
Ionic interactions
Hydrophobic Interactions
Van der Waal interactions
3
Why are weak interactions important?
cumulatively they are strong enough to stabilize structures, but individually they are weak enough to allow reversible and dynamic interactions.
4
Lower pKa means
stronger acid
5
Blood pH range
7.35-7.45
6
Carbonic acid-bicarbonate buffer system
pH control of blood
7
Carbonic Anhydrase
catalyzes the reversible reaction of carbon
8
What is the pKa of the carbonic acid-bucarbonate buffer system?
6.4
9
Dihydrogen phosphate-hydrogen phosphate system
controls intracellular pH
10
What is the pKa of dihydrogen phosphate-hydrogen phosphate system?
7.0
11
What aa helps with the dihydrogen phosphate-hydrogen phosphate system?
histidine
12
3 buffer systems
carbonic acid-bicarbonate buffer system
dihydrogen phophate-hydrogen phosphate system
proteins
13
How are proteins part of the buffer system?
contain acidicasic groups and pKa values near 7.0
14
What amino acid is important in the buffer system proteins? Why?
histidine because of the side chain imidazole
15
H-bonds are strongest when the electronegative atoms and hydrogen are...
collinear
16
Hydrophobic effect
hydrophobic molecules are forced together and are entropy-driven
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