1Chemotherapy
the use of drugs to treat a disease
2Antimicrobial drugs
interferes with the growth of microbes within the host
3Antibiotic
Substances produced by a microbe that, in small amounts, inhibits another microbe
4Selective Toxicity
a drug that kills harmful microbes without damaging the hosts
5Most antibiotics come from ….
Bacteria (over half orginate from Streptomyces)
6Broad-spectrum drug
an antibiotic that is effective against a wide range of both gram positive and/or gram negative bacteria
7Killing of Bacteria
Bactericidal
8Inhibting Bacteria growth
Bacteriostatic
9Cell Membrane Inhibitors
Polymyxins
10Cell Wall Inhibitors
Penecillian, Cephalosporins, Vancomycin, Bacitracin, Monobactams
11Metabolic Inhibitors
Sulfonamides, Trimethoprim
12DNA replication inhibitors
Quinolones
13RNA Polymerase Inhibitors
Rifampin, Pyronins
14Protien Synthesis Inhibitors- target ribosomes
Chloramphenicol, macrolides (erythromycin), clindamycin, oxazolidinones (linezolid), streptogramines (synercid); Aminoglycosides (gentmicin), tetracyclines (doxycycline)
15Antifungal Drugs
Inhibition of Ergosterol Synthesis (membrane), cell wall synthesis, synthesis of B-glucan, nucleic acids, microtubules
16Flucytosine
Cytosine analog interferes with RNA synthesis
17Antifungal- Inhibit Ergosterol synthesis
Azoles- Miconazole, triazole