(724)parkinsons
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1
what is the primary cause of parkinsons
degeneration of dopaminergic neurons in substantia nigra
2
pts with parkinsons have to much _____ influence
AcH
3
T/F
dopamine can cross the BBB
dopamine can cross the BBB
falsssseeeeeee
4
what needs to be dosed with dopamine to cross BBB
levodopa
5
What does carbidopa do?
inhibits dopa decarboxylase
prevents premature conversion
prevents premature conversion
6
Oral administration of dopamine is NOT effective in the treatment of Parkinson disease because dopamine is
unable to pass from the blood stream into the brain
7
t/f
L-DOPA will cross BBB and be converted to dopamine
L-DOPA will cross BBB and be converted to dopamine
trueeee
8
what are the side effects of L-Dopa?
GI irritation, hypotension, Psychotropic, behavioral effects, dyskinesia, freezing of gait
9
what is caused by a decreased response of Ldopa towards the end of their dose cycle?
end of dose akinesia
10
what type of ldopa is used to treat the "off" or freezing episodes
inhaled L-Dopa
11
after ____ years of L-DOPA Benefits may be lost, or dyskinesias become intolerable
4 to 5
12
t/f
L-DOPA is effective in treating Parkinson disease because it crosses the BBB where it is them converted to dopamine
L-DOPA is effective in treating Parkinson disease because it crosses the BBB where it is them converted to dopamine
true
13
t/f
Common side effects of L-DOPA include GI irritation, hypotension, hallucinations, behavioral effects, dyskinesias, and freezing of gait
Common side effects of L-DOPA include GI irritation, hypotension, hallucinations, behavioral effects, dyskinesias, and freezing of gait
true
14
t/f
Patients may experience good effects from L-DOPA initially, but fluctuations in response and eventual loss of effects can occur after several years
Patients may experience good effects from L-DOPA initially, but fluctuations in response and eventual loss of effects can occur after several years
true
15
What do COMT inhibitors do?
protects LDOPA in the body allowing it to reach the brain
(inhibits breakdown of dopamine by catechol-o-methyltransferase. When carbidopa is given to inhibit decarboxylase, COMT production is increased to compensate. So COMT inhibitors are useful along with CD/LD.)
(inhibits breakdown of dopamine by catechol-o-methyltransferase. When carbidopa is given to inhibit decarboxylase, COMT production is increased to compensate. So COMT inhibitors are useful along with CD/LD.)
16
What do anticholinergics do?
Decrease acetylcholine influence
may help ↓ rigidity and tremor
may help ↓ rigidity and tremor
17
what do MAO-B inhibitors
Inhibit monoamine oxidase type B (MAO-B)
prolong dopamine effects in brain
prolong dopamine effects in brain
18
what does Amantadine (Symmetrel) do?
Antiviral agent... antiparkinson effects discovered by chance
↓'d chance of dyskinesias
Blocks NMDA receptor in brain... decreases influence of excitatory amino acids (glutamate)
↓'d chance of dyskinesias
Blocks NMDA receptor in brain... decreases influence of excitatory amino acids (glutamate)
19
what is the optimal treatment time for therapy and pts taking parkinson meds?
30-60 minutes AFTER
20
Although the cause of PD is not known, free-radicals might be the cause of damage to substantia nigra neurons, and anti-oxidant therapies might ultimately be discovered that delay or prevent this condition
cool
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