Transportation of Vesicles ER to Golgi

COP2 vesicles are in charge of transporting vesicles from ER to Golgi.
COP1 vesicles are in charge of transporting escaped resident proteins from Golgi back to ER.

Exit site regions

Because the cargo proteins have an exit signal recognized by COP2 components.

After transport vesicles have bud off ER and shed their coats they will begin to interact with other vesicles.
With the help of matching SNARES the vesicles will fuse with each other.

Structures that form from homotypic fusions.
Function as transport packages that bring material from ER to Golgi.
Bud's vesicles off coated with COP1.

The VTC will be in charged of shipping escaped resident proteins back to the ER. Proteins with the KDEL retreival signal will be returned.

A KDEL sequence/Retrieval signal at their c terminal end.
Binds to KDEL receptors

KDEL receptor will bind to any multipass transmembrane protein with KDEL sequence
Gets packaged into a COP1 coated transport vesicle.

KDEL sequence affinity is higher for receptors in tubular clusters of golgi due to escaped resident proteins.
KDEL sequence affinity is lower for receptors in ER due to unloading of cargo.

Cis face (vesicle entrance) and trans face (vesicle exit). The CGN or cis golgi network and the TGN or trans golgi network.

Proteins, Lipids.
They can either continue in Golgi or returned to ER.
Exiting they are sorted to next destination: lysosomes, vesicles, cell surface.

The vesicles from the ER will begin forming the new CGN of Golgi. The old TGNs proteins will bud off and join the new TGN (old medial cisterna).

Glycoproteins, Proteoglycans.

Synthesized similar to N-linked, Glycosyl transferase in lumen of Golgi.