LEC 13 BIOL 431
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1
What is the total atmosphere pressure and what are the Partial pressures?
ATM = 760 mmHg
Nitrogen 78% = PN2 597 mmHg
oxygen 20.9% =PO2 160mmHg
Carbon Dioxide 0.04% = PCO2 0.3mmHg
Nitrogen 78% = PN2 597 mmHg
oxygen 20.9% =PO2 160mmHg
Carbon Dioxide 0.04% = PCO2 0.3mmHg
2
What does Henrys Law state?
Pressure, solubility, and temp effect behavior of gas in liquid
Increase in temp = decreases in solubility
CO2 has greates solubility
o2 has 1/20 the sol of co2
Increase in temp = decreases in solubility
CO2 has greates solubility
o2 has 1/20 the sol of co2
3
What factors influence the movement of gas over the resp membrane?
PP of gas
solubility of gas
pulmonary vent rate
surface area of membrane
thickness of membrane
solubility of gas
pulmonary vent rate
surface area of membrane
thickness of membrane
4
What are the 2 methods of blood transport?
Dissolved in plasma 1.5%
Bound to hemoglobin 98.5%
Bound to hemoglobin 98.5%
5
What are the 3 notable structures in hemoglobin?
Hema pigments = nitrogen protein holding iron
Iron (Fe) = oxygen carrier = 1 unit / 4 units per hemoglobin
Protein = called globin
Iron (Fe) = oxygen carrier = 1 unit / 4 units per hemoglobin
Protein = called globin
6
What is oxygen affinity?
How fast the polygon can bind and unbind from the hemoglobin
7
What are the normal conditions for hemoglobin unloading 02?
20% of 02 us released of hemoglobin to tissue
8
What is the increased unloading of o2?
When in o2/energy is needed > CO2 builds up > leading to quicker release of o2 due to pressure gradient
9
What causes a R shift in the curve and what does this mean?
Increase in temp
increase in PCO2
decreas in pH
increase in 2,3 Biophosphoglycerate (BPG)
Means decreased affinity
increase in PCO2
decreas in pH
increase in 2,3 Biophosphoglycerate (BPG)
Means decreased affinity
10
What cause a L shift in the curve and what does this mean?
Increase in pH
decreases in temp
decrease in PCO2
decrease in BPG
decreases in temp
decrease in PCO2
decrease in BPG
11
What is 2,3 Biphosphoglycerate ?
Byprodyct of burning ATP
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