1The general composition of the digestive system is...
the gastrointestinal tract, the 3 pairs of salivary glands, the liver, the gallbladder, and the pancreas
2What are the stages of the digestive process?
ingestion, mechanical digestion and movement, secretion, chemical digestion, absorption, and elimination
3What is ingestion?
taking in food through the oral cavity
4What is mechanical digestion and movement?
chewing breaks food into smaller pieces, and two types of movement, segmentation and peristalsis, mix it and propel it forward
5What is peristalsis?
peristaltic movement is a ring of contraction along the wall of the tube, allowing food to be pushed forward due to the area beyond the wall relaxing
6What is segmentation?
contraction and relaxation occur randomly, which moves contents within the lumen. food particles are pressed against the mucosa, which helps absorb nutrients
7What is secretion?
the secretion of fluid, digestive enzymes, acid, alkali, bile, and mucus into the GI tract at various locations. several hormones that regulate digestion are also secreted into the bloodstream
8What is chemical digestion?
contents in the lumen are broken down into smaller nutrient molecules using specific enzymes like starch amylase
9What is absorption?
nutrient molecules passing through the mucosal layer of the GI tract into the blood or lymph
10What is elimination?
the expulsion of undigested material in the body
11What is the composition of the GI wall?
the mucosa, the submucosa, the muscularis, and the serosa
12Describe the mucosa
the innermost layer of squamous epithelium cells, mostly simple columnar. it is the site of secretion and absorption
13Describe the submucosa
dense CT with blood and lymph vessels, lymph nodules, and nerves
14Describe the muscularis layer
2-3 layers of smooth muscle. contains sphincters (specialized circular smooth muscle) that regulate movement through the GI tract
15Describe the serosa
outermost serous layer composed of visceral peritoneum. it protects underlying tissues and secretes serous fluid for lubrication
16Explain the epithelium in each portion of the GI tract
the stomach and both intestines are lined with simple columnar epithelium. the oral cavity is stratified squamous, keratinized for the lips and nonkeratinized for the other parts (like the esophagus' mucosa layer)
17How is the digestive tract innervated?
the ANS maintains muscle tone and regulates the strength, rate, and velocity of muscle contractions and regulations secretions
18What are the sympathetics of the GI tract?
it decreases the rate of muscle contraction and secretion (SMOOTH muscle)
19What are the parasympathetics of the GI tract?
it increases the rate of muscle contraction and secretion (SMOOTH muscle)
20Postganglionic fibers play what role in innervation?
they are arranged into nerve plexuses called the submucosal plexus (controls secretions) and myenteric plexus (controls motility)
21Describe the mouth
the entrance to the GI tract lined by stratified squamous epithelium because it is subject to abrasion
22What does the mouth do?
it receives food and begins mechanical digestion via mastication and moving them with saliva to form a bolus for swallowing. it forms speech and receives tastes
23Describe the tonsils
they form a ring of lymphoid tissue including the pharyngeal, lingual, and palatine (paired) tonsils
24What do lymphoid tissues do?
they protect the entryway to the body from harmful microbes
25Describe the teeth
there are 20 primary teeth and 32 permanent teeth. they consists of a crown (visible region) and root (below gingiva). enamel covers the crown, dentin is below the enamel, and pulp is below the dentin
26What do the teeth do? How are they innervated?
teeth are for mastication (tear, grind, and break food into smaller pieces). they are innervated by the trigeminal nerve (CNV). a bundle of vessels pass through the root canal
27What is a root canal?
the death of a tooth nerve caused by blocked blood flow
28Describe the tongue
a thick, muscular organ lined by a mucous membrane, anchored to the hyoid bone and the frenulum
29What are the functions of the tongue?
it mixes food particles with saliva during chewing, moves/positions food below the teeth for chewing, and moves food toward pharynx during swallowing
30What is the pharynx?
the passageway from the oral cavity to the esophagus/larynx
31Describe the nasopharynx
behind the nasal conchae, contains the pharyngeal tonsil and eustachian opening
32Describe the oropharynx
below the nasopharynx and behind the uvula, contains the palatine and lingual tonsils
33Describe the laryngopharynx
common entryway from trachea to the esophagus (notice the epiglottis)
34What does the pharynx do?
when food enters the pharynx, the swallowing reflex is triggered. once it is triggered, it CANNOT be stopped
35What is the esophagus?
a collapsed, hollow, muscular tube lying behind the trachea. it is about 12 inches in length, and lined by stratified squamous epithelium. it penetrates through the esophageal hiatus to the diaphragm to enter the abdominal cavity
36Describe the esophagus' functions
carries solid foods/liquids to the stomach
37What does the cardiac sphincter do?
it is a collapsed region at the terminal end of the esophagus that prevents acidic stomach contents from backing up into the esophagus. fun fact: this is what causes heartburn
38Describe the stomach
there is an abrupt epithelial change from stratified squamous epithelium to simple columnar epithelium with goblet cells (form gastric glands). this means the area is subject to dysplasias or pre-cancerous conditions due to cells losing control of mitosis
39What does the stomach do?
it stores food, chemically digests proteins, absorbs lipid-soluble substances, and regulates delivery into the small intestine. it empties in about 2-6 hours
40Explain the gastric glands
they secrete gastric juice (2-3 L/day, pH 1.6-2.6). the epithelium of the stomach has millions of gastric pits that lead to gastric glands
41What do mucus neck cells do?
one type of gastric gland cell. it produces mucous to protect the stomach mucosa
42What do chief cells do?
another gastric gland cell. secretes pepsinogen, an inactive form of the pepsin enzyme
43What do parietal cells do?
final gastric gland cell. secretes pre-hydrochloric acid which becomes HCl and intrinsic factor
44How are gastric secretions regulated?
the parasympathetic nervous system regulates the release of gastric juice
45How is stomach emptying regulated?
an empty stomach has tonic muscle contraction to keep it small. after eating, tonic contractions cease and the stomach relaxes and stretches to accommodate the food, which allows for volume increase. 2-6 hours later, the stomach contractions so secretions move to the small intestine. mixing waves mix the stomach contents with stomach secretions to form chyme, and gastrin and the stretch of the stomach stimulate emptying
46Describe the small intestines and its subdivisions
it begins right after the pyloric sphincter and extends to the ilio-cecal junction (about 20 ft). contains circular folds, villi (mucosa projections) and microvilli (simple columnar epithelial cells)
duodenum: first division, 10 inches. receives bile via the common bile duct from the liver and gallbladder, receives pancreatic juice via the pancreatic duct from the pancreas, and the sphincter of Oddi controls emptying these ducts
jejunum: the left side of the small intestine
ileum: right side of the small intestine, joins the large intestine at the ilio-cecal joint
47What does the small intestine do?
absorbs about 90% of absorbable nutrients
48Describe the intestinal juice
releases 1-2 L/day, pH of 7.4-7.8. it includes mucous (alkaline) which neutralizes stomach acids that protect against stomach acids and digestive enzymes. also contains digestive enzymes for proteins, carbs, lipids, and nucleic acids and hormones that control pancreaticallbladder secretions
49How are small intestinal secretions regulated?
the distension of the intestinal wall stimulates parasympathetic reflexes that cause secretions
50How does the small intestine move?
the stretch of smooth muscles, local reflexes, and the PNS stimulate contractions of the GI wall
51Describe the large intestine
begins at the cecum and ends at the anus (5ft). the laminal surface is lined with simple columnar epithelium up to the anal canal, then becomes the stratified squamous epithelium
52What does the large intestine do?
it absorbs water, electrolytes, and vitamins, performs last stages of chemical digestion through normal flora actions, and compacts intestinal contents into feces and eliminates semisolid waste
53What are the subdivisions of the large intestine?
the cecum, the colons, the rectum, the anal canal, and the anus
54What is the cecum?
first portion of the large intestine; blind-ended pouches with vermiform appendix (lymphoid tissue)
55What are the colons?
ascending colon (up to right colic flexure), transverse colon (right to left colic flexure), descending colon, and the sigmoid colon
56What is the rectum?
the straight portion that connects colon to anus, it contains a trio of transverse folds called rectal valves, which separate feces from gas to prevent simultaneous passage
57What is the anal canal?
begins when the rectum passes through the pelvic floor. puborectalis does all the work
58How does secretion and absorption occur in the large intestine?
mucous is secreted to protect the intestinal lining and HCO3- (bicarbonate) by epithelial cells. NA+ is absorbed by active transport and water is absorbed via osmosis
59What are the movements in the large intestine?
segmental movements mix the colon's contents, mass movements are big peristaltic contractions (3-4/day)
60Describe defecation
the elimination of feces (unabsorbed substances, bacteria, and old epithelial cells)
61What is the defecation reflex?
triggered by a deep breath and contracting abdominal wall muscles. this increases abdominal pressure, forcing feces into rectum. it triggers peristaltic waves and the internal anal sphincter relaxes. voluntary activation needs the puborectalis and external anal sphincter to RELAX
62Explain the individual salivary glands
parotid: sides of cheeks before the ears
sublingual: below the tongue
submandibular: below the jaw at an angle
63What is the saliva? What is it composed of?
it moistures food and begins carb digestion. it is produced (1000-1500mL/day) continuously, most of it being water. a small amount is salivary amylase and mucin
64What is salivary amylase?
an enzyme that begins starch digestion, located in the oral cavity
65What is mucin?
mucous protein that holds food particles together
66What is lysozyme?
inhibits bacterial growth
67What is bicarbonate?
HCO3-, maintains pH 6.5-7.5 for enzymes
68How is saliva production controlled?
sympathetics stimulate small secretions of viscous saliva, parasympathetics stimulate large secretions of watery saliva
69What is the pancreas?
an elongated, pinkish-gray organ that is 6 inches in length extending from the duodenum to the spleen (BEHIND stomach)
70Describe the endocrine and exocrine portion of the pancreas
endocrine: islets of Langerhans secrete hormones (ductless)
exocrine: acini secrete pancreatic juice by connecting to the duct system that forms the pancreatic duct (empties in duodenum)
71What comprises pancreatic juice?
1200-1500mL is produced each day. it is mainly water, but contains bicarbonate to neutralize gastric acids.
72What is the liver?
a large, vascular organ in URQ that is easily subject to trauma
73What are the main functions of the liver?
it produces bile and manufactures plasma proteins (albumin and fibrinogen) from amino acids, and destroys RBCS and bacteria
74How does bile function?
neutralizes gastric acids and emulsifies fats/lipids which aid lipase action
75What is the gallbladder and its functions?
it stores and concentrates bile (up to 10x as concentrated). cholycystokinin triggers the gallbladder to release bile, which is released as a response to the presence of lipids and proteins in the small intestine
76What is pancreatic amylase?
partially digests starch, produced in pancreas and acts in small intestine
77What is pancreatic lipase?
converts lipids to glycerol and free fatty acids. produced in the pancreas and released in the small intestine
78What does hydrochloric acid do?
makes the stomach very acidic, which kills bacteria and breaks down CT in meat, as well as activating pepsin
79What does intrinsic factor do?
aids the absorption of vitamin B (metabolism) in the small intestine
80Elaborate on the enterogastric reflex
the enterogastric reflex is triggered by distension of small intestine and inhibits peristalsis in the stomach to slow movement of food into the duodenum
81Internal anal sphincter
smooth muscle
82External anal sphincter
skeletal muscle
83Intestinal (brush border) enzymes
completes starch digestion, produced in small intestinal epithelium
84Trypsin
digests proteins, produced in pancreas from trypsinogen, activated in small intestine
85Pepsin
digests proteins, produced in stomach from pepsinogen, activated by low stomach pH
86What do proteins break down into?
small polypeptides (amino acids)
87What does starch break down into?
glucose
88What do nucleic acids break down into?
nucleotides
89What do lipids break down into?
emulsifies into smaller lipids which become monoglycerides and free fatty acids
90Bile salts
lipids are emulsified, protected by the liver, concentrated by gallbladder, and released into the small intestine
91Nuclease
breaks down nucleic acids